First was the Roller Controller, a trackball packaged with a port of the arcade game Slither, a Centipede clone and meant to be used with some dedicated games like Victory or to enhance the gameplay of previously published cartridges which benefitted from its trackball system ( like Wargames ).

* First to synthesize human growth hormone and clone into bacteria, setting the stage for genetically engineered human growth hormone

First, Allison Mann competed with her father to create the world's first human clone.

A giant clone of Keniclius, named Keniclius Five, kidnaps First Officer Spock.

First, although home glucose meter readings are often misleading, the probability that a low reading, whether accompanied by symptoms or not, represents real hypoglycemia is much higher in a person who takes insulin than in someone who does not.

* 1922 – First use of insulin to treat diabetes in a human patient.

First, when a cell needs energy, insulin can bind with a special purpose receptor on the surface of a cell ( about 2 / 3 of human body cells, including muscles, but not including nerve cells ).

* First company worldwide to develop human insulin on a Pichia expression system ( 2003 )

First, the level of transcription of a gene gives only a rough estimate of its level of expression into a protein.

First, the affected gene in most cases is that for a transport protein ( StAR ) rather than a steroidogenic enzyme.

First, the methylation of DNA itself may physically impede the binding of transcriptional proteins to the gene, and second, and likely more important, methylated DNA may be bound by proteins known as methyl-CpG-binding domain proteins ( MBDs ).

* First Hit: The first hit is classically thought of as a point mutation that inactivates one copy of a tumor suppressor gene ( TSG ), such as Rb1.

* First research center to discover the gene for open-angle glaucoma.

A third Thomas Bushell ( 1594-1674 ), `` much loved '' by Bacon, called himself `` The Superlative Prodigall '' in The First Part of Youths Errors ( 1628 ) and became an expert on silver mines and on the art of running into debt.

First came the cannon fodder, white-clad civilians being driven into death as a massive human battering ram.

First thing I did after my twenty-first birthday was go into court and have it officially changed, and this is something I don't tell everybody.

First, there were those Congolese ( among them Joseph Kasavubu ) who favored splitting the country into small independent states, Balkanizing it.

First I've got to intercept my brothers before they get any deeper into trouble.

The provinces of Turkey are organized into 7 census-defined regions (), which were originally defined at the First Geography Congress in 1941.

First plutonium-239 nitrate (< sup > 239 </ sup > PuNO < sub > 3 </ sub >) solution was coated on a platinum foil of about 0. 5 cm < sup > 2 </ sup > area, the solution was evaporated and the residue was converted into plutonium dioxide ( PuO < sub > 2 </ sub >) by annealing.

First mentioned by the Romans in 213, the Alamanni captured the Agri Decumates in 260, and later expanded into present-day Alsace, and northern Switzerland, establishing the German language in those regions.

First, he went into exile in France.

* 1327 – First War of Scottish Independence: James Douglas leads a raid into Weardale and almost kills Edward III of England.

The Sedition Act of 1798 and the Incorporation of Seditious Libel into First Amendment Jurisprudence.

Hence the fatalistic strain of the poems, and the earlier settings, foreshadowed responses to the universal bereavement of the First World War and became assimilated into them.

From 1946 through 1985, the army was divided into four numbered armies: the First Army was centered in Rio de Janeiro, the Second Army in São Paulo, the Third Army in Porto Alegre, and the Fourth Army in Recife.

Following success as the successor to the Whig party, the party's share of the popular vote plummeted after the First World War as it lost votes to the new Labour party and fractured into groups such as the National and Coalition Liberals.

The transformation from the stalemate of the First World War into tremendous initial operational and strategic success in the Second, was partly the employment of a relatively small number of mechanised divisions, most importantly the Panzer divisions, and the support of an exceptionally powerful air force.

* Michael Everson's First proposed encoding into Unicode and ISO / IEC 10646 of Blissymbolics characters, based on the decomposition of the ISO-IR / 169 repertoire.

Among these actions were the Seven Years ' War, the American Revolutionary War, the Napoleonic Wars, the First and Second Opium Wars, the Boxer Rebellion, the New Zealand land wars, the Sepoy Rebellion of 1857, the First and Second Boer Wars, the Fenian raids, the Irish War of Independence, its serial interventions into Afghanistan ( which were meant to maintain a friendly buffer state between British India and the Russian Empire ), and the Crimean War ( to keep the Russian Empire at a safe distance by coming to Turkey's aid ).

The House of Bonaparte is an imperial and royal European dynasty founded by Napoleon I of France in 1804, a French military leader who rose to notability out of the French Revolution and transformed the French Republic into the First French Empire within five years of his coup d ' état.

First, informal changes were made to the order of the various parts of the service and inserting words indicating a sacrificial intent to the Eucharist ; secondly, as a result of Bishop Rattray's researches into the liturgies of St. James and St. Clement, published in 1744, the form of the invocation was changed.

It soon occurred to Chaplin that it was turning into a large project, so to placate First National he halted production and quickly filmed A Day's Pleasure.

First, its mix consistency is fluid and homogeneous, allowing it to be poured into forms rather than requiring hand-layering together with the placement of aggregate, which, in Roman practice, often consisted of rubble.

Popes, bishops, and priests married and sired children for over a thousand years after Christ Celibacy was first written into law for all priests in the 12th century at the First Lateran Council ( 1123 ).

He declares the pope to be: " his Lord and Father in Christ ", " The Chosen Watchman ", " The Prelate most dear to all the Faithful ", " The most beautiful Head of all the Churches of the whole of Europe ", " Pastor of Pastors ", " The Highest ", " The First ", " The First Pastor, set higher than all mortals ", " Raised near into all the Celestial Beings ", " Prince of the Leaders ", " His Father ", " His immediate Patron ", " The Steersman ", " The Pilot of the Spiritual Ship " ( Allnatt, " Cathedra Petri ", 106 ).

While using both the swabbing and cultivation approach for the detection of microorganisms on a surface, two impairing factors have to be accounted for: First, not all bacteria present on a surface will be taken up by the swab and second, not all the bacteria taken up will be released again from the swab.

The benefit of using live rock is fourfold: First, live rock acts as a biological filter, adding beneficial bacteria.

* 1861 – First performance of Arthur Sullivan's debut success, his suite of incidental music for The Tempest, leading to a career that included the famous Gilbert and Sullivan operas.

Aachen was chosen as the site of several important congresses and peace treaties: the first congress of Aachen ( often referred to as Congress of Aix-la-Chapelle in English ) in 1668, leading to the First Treaty of Aachen in the same year which ended the War of Devolution.

In 325, at the age of 27, Athanasius had a leading role against the Arians in the First Council of Nicaea.

Christianity: The First Three Thousand Years ( Viking ; 2010 ) 1, 161 pages ; survey by leading historian

Previous editions of War and Remembrance, The Bloodstone Hunt, Operation Rebirth, Man Without a Country, and To Serve and Protect were released prior to new 2010 editions leading up to the Captain America: The First Avenger feature film.

Albert had a successful military career leading Saxon troops which participated in the First War of Schleswig, the Austro-Prussian War, and the Franco-Prussian War.

He was again the First Division's leading goal scorer, this time with 30 goals, and helped Everton finish second in the league.

The death of Uthman was followed by a civil war known as the First Fitna, and the succession to Ali ibn Abi Talib was disputed, leading to the split between the Sunni and Shia sects, and later to competing caliphates when the descendants of Muhammad through his daughter Fatimah and Ali set up separate Fatimid societies.

His father, Hamilcar Barca, was the leading Carthaginian commander during the First Punic War, his younger brothers were Mago and Hasdrubal, and he was brother-in-law to Hasdrubal the Fair.

* 2003 First ever President of Leukaemia Research, the UK's leading blood cancer charity.

First evidence for this third neutrino type came from the observation of missing energy and momentum in tau decays analogous to the beta decay leading to the discovery of the neutrino.

Nestorius and his teachings were eventually condemned as heretical at the First Council of Ephesus in 431 and the Council of Chalcedon in 451, leading to the Nestorian Schism in which churches supporting Nestorius broke with the rest of the Christian Church.

Nestorius himself always insisted that his views were orthodox, though they were deemed heretical at the First Council of Ephesus in 431, leading to the Nestorian Schism, when churches supportive of Nestorius broke away from the rest of the Christian Church.

* 1390 – First trial for witchcraft in Paris leading to the death of three people.

By the time of the First World War, the mass advertising and popularity of the Victor Talking Machine Company's Victrolas ( a line of disc-playing machines characterized by their concealed horns ) was leading to widespread generic use of the word " victrola " for any machine that played discs, which were however still called " phonograph records " or simply " records ", almost never " victrola records ".

First, the half-life of the p53 protein is increased drastically, leading to a quick accumulation of p53 in stressed cells.

OMA New York: the office in Manhattan Koolhaas is leading by Shohei Shigematsu is now designing an extension of Cornell University ( NY ), 111 First Street, a high rise residential building and hotel in Jersey City ( NJ ) and a high end residential tower with CAA screening room at One Madison Park in NYC.

In 16 December 1880 the independence of the republic was proclaimed again, leading to the First Boer War.

The leading critics of the law, Thomas Jefferson and James Madison, argued for the Acts ' unconstitutionality based on the First Amendment, among other Constitutional provisions ( e. g. Tenth Amendment ).

Even when laws are upheld, the complication of compliance with the First Amendment requires careful and cautious drafting of legislation, leading to laws that are still fairly limited in scope, especially in comparison to those of other countries such as the United Kingdom, France or Canada.

In 1871 the Germans expelled most of the English-speaking members of the First International's U. S. sections, leading to the quick decline of the organization, as it failed to attract the ethnic working class in America.

Hillary Rodham Clinton, leading policy proposals, traveling abroad as a State Department representative to 82 nations, advising her husband, and being elected a Senator ( in 2000 ), is the most openly empowered and politically powerful First Lady in American history ; Madeleine Albright and Janet Reno take two of the cabinet's top jobs as United States Secretary of State (# 1 ), and United States Attorney General (# 4 ), respectively.

* January 4 – First English Civil War: Charles I attempts to arrest 6 leading members of the Long Parliament, but they escape.

* January 18 – The leading ship in Captain Arthur Phillip's First Fleet arrives at Botany Bay to colonise Australia .< noinclude >