The ventral neural tube is patterned by Sonic Hedgehog ( Shh ) from the notochord, which acts as the inducing tissue.

In addition to being a standalone game, through a system dubbed " lock-on technology ," Sonic & Knuckles acts as an expansion pack to both Sonic the Hedgehog 2 and Sonic the Hedgehog 3, the latter with which it was developed in tandem.

Sonic the Hedgehog himself is not playable, but acts as the guide.

In Sonic Generations there is a poster that can be found in both acts of the City Escape stage that features images of Ray and Mighty, taken from SegaSonic the Hedgehog.

Sonic the Hedgehog ( character ) | Sonic and Miles " Tails " Prower | Tails run through the " Carnival " level, connected by a tether.

Scenario Mode has the player going through thirteen levels facing against Robotnik's badniks ( which include Scratch, Grounder, Coconuts, and various badniks from the first episode of Adventures of Sonic the Hedgehog ) before facing off against Robotnik himself.

Sonic the Hedgehog is driving through rural Nebraska in the search for more creatures to discover.

The European Hedgehog is endemic to Europe ( including European Russia ), with a global distribution extending from the British Isles and the Iberian peninsula, eastwards through much of western to central Europe ; and from southern Fennoscandia, and the northern Baltic to north-west Russia.

Hedgehog passes through the woods and encounters a beautiful white horse standing in a fog.

The game built a cult following through word of mouth, and it was further aided by the Mega Drive's Christmas 1991 sales spike, caused by the release of Sonic the Hedgehog.

Sonic the Hedgehog: only playable through hacking.

The story behind Sonic the Fighters is that a bored Sega-AM2 programmer working on Fighting Vipers decided to put in Sonic the Hedgehog in the game for amusement ( through hacking both Sonic and Tails are playable ).

The episode produced spoofs of a number of cultural icons, including passing references to Chronic the Hedgehog and Dungeons & Dragons, as well as a Richard O ' Brien stand-in named " Robin O ' Hood " who in the episode leads Gary and Graeme through the Merry Men's version of The Crystal Maze.

Those attacks combined with Maxime Weygand's Hedgehog tactic would become the major basis for responding to blitzkrieg attacks in the future: deployment in depth, permitting enemyor “ shoulders ” of a penetration was essential to channeling the enemy attack, and artillery, properly employed at the shoulders, could take a heavy toll of attackers.

* Bunnie Rabbot in the Sonic the Hedgehog Saturday morning TV series and US comic series.

How It Works, compared chauvinistic husbands to the hedgehog from a well-known Russian fable, The Hedgehog and the Fox ; they have one way of thinking, and it is so engrained that they cannot change it.

" He also had predictable habits, which were noted by the Viennese press, such as his daily visit to his favourite " Red Hedgehog " tavern in Vienna, and his habit of walking with his hands firmly behind his back ( once again, like Beethoven ), which led to a caricature of him in this pose walking alongside a red hedgehog.

* Intermolecular transesterification can transfer a whole segment from one polypeptide to another, as is seen in the Hedgehog protein autoprocessing.

In the early 1980s, Hedgehog brand flavored crisps were widely on sale and received much publicity.

Sonic Team are best known for the Sonic the Hedgehog series.

In 1990, Sega asked to create a game with a character that was popular enough to rival Nintendo's Mario, resulting in the creation of Sonic the Hedgehog.

In 1991 AM8 took its name from the Sonic the Hedgehog series and became Sonic Team.

Following the release of Sonic The Hedgehog, Yuji Naka grew dissatisfied with Sega Japan's policies and so moved to Sega of America to work in the offices of the newly established Sega Technical Institute, headed by Mark Cerny.

The American developers collaborated with Sonic Team in the development of Sonic the Hedgehog 2.

The Sega Dreamcast followed in 1998, and launched with the return of Sonic the Hedgehog in Sonic Adventure.

In 2009, the director of Sonic Unleashed and creator of the Hedgehog Engine, Yoshihisa Hashimoto, left Sonic Team to move to Square Enix.

In 2010, it was confirmed that Dimps, developers of the Sonic Advance and Sonic Rush titles, would be co-developing Sonic the Hedgehog 4 with Sonic Team.

All of the team members that worked at Sega Studio USA were Japanese, with the exception of Brad Wagner who was hired at the studio during the development of Shadow the Hedgehog.

Sega Studio USA went on to make their next multiplatform game, Shadow the Hedgehog, using the studio's own game engine instead of RenderWare.

While the original Sonic the Hedgehog was developed in Japan by Sonic Team, Sonic the Hedgehog 2 was developed by Sonic Team in the US with several members of Sega Technical Institute assisting.

Sonic the Hedgehog 3 and Sonic & Knuckles were again developed by Sonic Team in the US, but this time with some of STI's musicians contributing to the score.

Sega Technical Institute held the principal responsibility for Sonic the Hedgehog Spinball instead.

Sonic Spinball was also developed by Polygames Interactive Limited released in 1993 for the Mega Drive / Genesis after Sonic the Hedgehog 2 Also STI developed Compile released Dr. Robotnik's Mean Bean Machine for the Mega Drive / Genesis after Sonic Spinball.

In 1994, less than two years after the release of Super Mario Kart, Sega released Sonic Drift ; a kart racing game featuring characters from the Sonic the Hedgehog series.

Popular titles included Sega's own series, notably Sonic the Hedgehog ; Disney movie extensions, such as The Lion King ; and 3rd-party developer games like Shaq Fu.

One exclusive game that was published for the Mega-CD is the now-famous Sonic the Hedgehog CD, or Sonic CD.

ADH acts by increasing water permeability in the collecting ducts and distal convoluted tubules ; specifically, it acts on proteins called aquaporins and more specifically aquaporin 2 in the following cascade ; ADH ( argenine vasopressin-AVP ) produced in the hypothalmus and stored in the posterior pituitary.

The endothelium normally provides a non-thrombogenic surface because it contains, for example, heparan sulfate which acts as a cofactor for activating antithrombin, a protease that inactivates several factors in the coagulation cascade.

DAF-2 acts to negatively regulate the forkhead transcription factor Daf-16 through a phosphorylation cascade.

This causes the cytosolic concentration of Calcium to increase, causing a cascade of intracellular changes and activity.

Another example of a multi-trophic interaction is a trophic cascade, in which predators help to increase plant growth and prevent overgrazing by suppressing herbivores.

Accumulating evidence also suggests that overfishing of top predators ( large predatory fish ) could indirectly increase algal growth by reducing grazing control performed by mesograzers such as crustaceans and gastropods through a trophic cascade.

Activation of the complement cascade attracts phagocytes that leak peroxide and other reagents, which may increase the damage for the surviving heart cells.

The thesis of the Uniting for Consensus group is that the increase of permanent seats would have further accentuated the disparity between the member countries and resulted in the extension of a series of privileges with a cascade effect.