Another major breakthrough, whose originators were once thought to be crazy, is the mixing of ethnic cuisines.

Alcohol withdrawal can also be a major contributing factor in breakthrough seizures, as well.

A major breakthrough in the development of the modern facsimile system was the result of digital technology.

The industry saw a major breakthrough in 1962 when the government granted the Sociedade de Turismo e Diversoes de Macau ( STDM ), a syndicate jointly formed by Hong Kong and Macau businessmen, the monopoly rights to all forms of gambling.

A major breakthrough in the understanding of materials occurred in the late 19th century, when the American scientist Josiah Willard Gibbs demonstrated that the thermodynamic properties related to atomic structure in various phases are related to the physical properties of a material.

Charles Thomson, co-founder of the group, described punk as " a major breakthrough " in his art.

This was a major breakthrough as more than a year of political wrangling could not yield an agreement despite pressure from the West and the Arab League.

( The idea of a major breakthrough with FS technology was dropped in the mid-1970s for cost-effectiveness and continuity reasons.

A major breakthrough in the methodology and popularization of volumetric analysis was due to Karl Friedrich Mohr, who redesigned the burette by placing a clamp and a tip at the bottom, and wrote the first textbook on the topic, Lehrbuch der chemisch-analytischen Titrirmethode ( Textbook of analytical-chemical titration methods ), published in 1855.

CL-20 is considered a major breakthrough in solid rocket propellant technology but has yet to see widespread use because costs remain high.

His first major breakthrough came in 1912 at age eighteen with his first book illustration for Carl H. Claudy's Tell Me Why: Stories about Mother Nature.

Pacino made his major breakthrough when he was given the role of Michael Corleone in The Godfather in 1972, which earned him an Academy Award nomination for Best Supporting Actor.

Zeffirelli's major breakthrough came the year after when he presented two teenagers as Romeo and Juliet, the perfect venue for 1968.

Weir's major breakthrough in Australia and internationally was the lush, atmospheric period mystery Picnic at Hanging Rock ( 1975 ), made with substantial backing from the state-funded South Australian Film Corporation and filmed on location in South Australia and rural Victoria.

His breakthrough role was in Jean-Luc Godard's Breathless ( 1960 ), which made him a major figure in the French New Wave.

Well before then, another major breakthrough occurred with the next event registered by BeppoSAX, GRB 970508.

However, the breakthrough came in 1856 when the Declaration of Paris, signed by all major European powers, stated that " Privateering is and remains abolished ".

According to his memoirs written after the war, the German Chief of Staff, Erich von Falkenhayn, believed that although a major breakthrough might no longer be achieved, the French army could still be defeated if it suffered a sufficient number of casualties.

His next major breakthrough came when producer Roy Speer introduced him to leading comic Ted Ray.

But the major breakthrough came the following year when-again under the leadership of Waechter-the Greens polled 10. 6 % in the European parliamentary elections.

As a comparative study it was a major breakthrough at the time.

Sketchpad is considered to be the ancestor of modern computer-aided drafting ( CAD ) programs as well as a major breakthrough in the development of computer graphics in general.

He is credited with the first major breakthrough in heavier-than-air flight and he worked over half a century before the development of powered flight, being acknowledged by the Wright brothers.

A major breakthrough was the introduction of portable defibrillators used out of the hospital.

The one major paratrooper attack was used earlier in Holland to capture a bridge and a number of small-scale glider-landings were conducted in Belgium to capture terrain dominating bottle-necks on planned routes of advance prior to the arrival of the main ground forces ( the most renowned being the landing on the Belgian border-fort of Eben-Emael ).

In their first major use at the Battle of Cambrai ( 1917 ), the plan was for a cavalry division to follow behind the tanks, however they were not able to cross a canal because a tank had broken the only bridge.

The Bordeaux bridge, Eiffel's first major work.

Instead, Pei ordered a hole cut through a nearby mountain, connected to a major road via a bridge suspended from ninety-six steel cables and supported by a post set into the mountain.

Since the construction of the Öresund bridge, Malmö has undergone a major transformation with impressive architectural developments, attracting new biotech and IT companies, and particularly students through Malmö University College.

As there is only one major bridge over the Niger ( The Kennedy Bridge in Niamey: the Niger River bridge at Gaya crosses into Benin ), car ferries are of crucial importance, especially the crossing at Bac Farie, 40 km north of Niamey on the RN4, and the car ferry at Ayorou.

Image: Wheeling West Virginia. jpg | Wheeling, West Virginia, a major city on the river, was the first city to have a bridge across the river.

The major geographical changes during this time period included the emergence of the Strait of Bosphorus and Skagerrak during glacial epochs, which respectively turned the Black Sea and Baltic Sea into fresh water, followed by their flooding ( and return to salt water ) by rising sea level ; the periodic filling of the English Channel, forming a land bridge between Britain and the European mainland ; the periodic closing of the Bering Strait, forming the land bridge between Asia and North America ; and the periodic flash flooding of Scablands of the American Northwest by glacial water.

They include a new speedway stadium, major shopping and entertainment centers, a commercial complex popularly called a " New Center of Toruń ", a music theater, a center of contemporary art, hotels, office buildings, facilities for the Nicolaus Copernicus University, roads and tram routes, sewage and fresh water delivery systems, residential projects, the possibility of a new bridge over the Vistula, and more.

He has seen through many major projects, including the Gibraltar bridge ( another fictional engineering triumph ).

Avoiding resonance disasters is a major concern in every building, tower and bridge construction project.

In 1790 he designed a bridge carrying the London-Holyhead road over the River Severn at Montford, the first of some 40 bridges he built in Shropshire, including major crossings of the Severn at Buildwas, and Bridgnorth.

Telford also worked on the North Wales coast road between Chester and Bangor, including another major suspension bridge at Conwy, opened later the same year as its Menai counterpart.

This bridge opened major international trade routes between northern Europe and Venice, and this began Regensburg's golden age as a residence of wealthy trading families.

The nearest major city is Yakutsk, away via an unpaved road which is best used in the winter, especially since there is no bridge over the Lena River at Yakutsk ( the choices are: ferry from Nizhny Bestyakh in the summer, when the rest of the road may not be passable due to standing water, or over the ice in the dead of winter ).

By the 1850s, when a major covered bridge was constructed at Philippi to service travellers on the Beverly-Fairmont Turnpike, the County's population was approaching 10, 000 people.

It is believed that, once developed ( along with the Northwest Passage ), the bridge will serve as major trade route between Europe and Asia.

A major road-rail bridge at Jamuna opened in 1998 to connect the previously isolated east and west rail networks.

The Øresund Bridge is the longest combined road and rail bridge in Europe, and connects two major metropolitan areas: those of the Danish capital city Copenhagen and the major Swedish city Malmö.

In Tom Clancy's Endwar, the Place de la Concorde is across the bridge from the spawn point and is a major firefight zone.

The KCS Railway bridge over the Neches River in Beaumont is a major transportation link for the region.