Another major breakthrough, whose originators were once thought to be crazy, is the mixing of ethnic cuisines.

A major breakthrough in bridge technology came with the erection of the Iron Bridge in Coalbrookdale, England in 1779.

Alcohol withdrawal can also be a major contributing factor in breakthrough seizures, as well.

A major breakthrough in the development of the modern facsimile system was the result of digital technology.

The industry saw a major breakthrough in 1962 when the government granted the Sociedade de Turismo e Diversoes de Macau ( STDM ), a syndicate jointly formed by Hong Kong and Macau businessmen, the monopoly rights to all forms of gambling.

A major breakthrough in the understanding of materials occurred in the late 19th century, when the American scientist Josiah Willard Gibbs demonstrated that the thermodynamic properties related to atomic structure in various phases are related to the physical properties of a material.

Charles Thomson, co-founder of the group, described punk as " a major breakthrough " in his art.

This was a major breakthrough as more than a year of political wrangling could not yield an agreement despite pressure from the West and the Arab League.

( The idea of a major breakthrough with FS technology was dropped in the mid-1970s for cost-effectiveness and continuity reasons.

A major breakthrough in the methodology and popularization of volumetric analysis was due to Karl Friedrich Mohr, who redesigned the burette by placing a clamp and a tip at the bottom, and wrote the first textbook on the topic, Lehrbuch der chemisch-analytischen Titrirmethode ( Textbook of analytical-chemical titration methods ), published in 1855.

CL-20 is considered a major breakthrough in solid rocket propellant technology but has yet to see widespread use because costs remain high.

His first major breakthrough came in 1912 at age eighteen with his first book illustration for Carl H. Claudy's Tell Me Why: Stories about Mother Nature.

Pacino made his major breakthrough when he was given the role of Michael Corleone in The Godfather in 1972, which earned him an Academy Award nomination for Best Supporting Actor.

Zeffirelli's major breakthrough came the year after when he presented two teenagers as Romeo and Juliet, the perfect venue for 1968.

Weir's major breakthrough in Australia and internationally was the lush, atmospheric period mystery Picnic at Hanging Rock ( 1975 ), made with substantial backing from the state-funded South Australian Film Corporation and filmed on location in South Australia and rural Victoria.

His breakthrough role was in Jean-Luc Godard's Breathless ( 1960 ), which made him a major figure in the French New Wave.

Well before then, another major breakthrough occurred with the next event registered by BeppoSAX, GRB 970508.

However, the breakthrough came in 1856 when the Declaration of Paris, signed by all major European powers, stated that " Privateering is and remains abolished ".

According to his memoirs written after the war, the German Chief of Staff, Erich von Falkenhayn, believed that although a major breakthrough might no longer be achieved, the French army could still be defeated if it suffered a sufficient number of casualties.

His next major breakthrough came when producer Roy Speer introduced him to leading comic Ted Ray.

As a comparative study it was a major breakthrough at the time.

Sketchpad is considered to be the ancestor of modern computer-aided drafting ( CAD ) programs as well as a major breakthrough in the development of computer graphics in general.

He is credited with the first major breakthrough in heavier-than-air flight and he worked over half a century before the development of powered flight, being acknowledged by the Wright brothers.

A major breakthrough was the introduction of portable defibrillators used out of the hospital.

Significantly, the initiation and leadership of a major proportion of the reform movements, especially those in the first half of the nineteenth century, came from men and women of New England birth or parentage and from either Trinitarian or Unitarian Congregationalism.

Algardi's first major commission came about in 1634, when Cardinal Ubaldini ( Medici ) contracted for a funeral monument for his great-uncle, Pope Leo XI, the third of the Medici popes, who had reigned for less than a month in 1605.

By the 1850s when they first came into sustained contact by outside groups, there were estimated 7, 000 Adamanese, divided into the following major groups:

The term originally came from antibody generator and was a molecule that binds specifically to an antibody, but the term now also refers to any molecule or molecular fragment that can be bound by a major histocompatibility complex ( MHC ) and presented to a T-cell receptor.

The major turn in Sakharov ’ s political evolution came in 1967, when anti-ballistic missile defense became a key issue in US – Soviet relations.

However, some researchers have disputed the major league status of the Union Association, pointing out that franchises came and went and contending that the St. Louis club, which was deliberately " stacked " by the league's president ( who owned that club ), was the only club that was anywhere close to major league caliber.

The first major computer product that came from this marriage was the B205 tube computer.

The alliance commonly known as the Second Triumvirate, renewed for a five-year term in 38 BC, broke down when Octavian came to perceive Caesarion, the son of Julius Caesar and the Egyptian Queen Cleopatra VII, as a major threat to his power.

A major military base was built in Kenya, and the African colonies came under an unprecedented degree of direct control from London.

This idea came from common law, and the earliest conception of a criminal act involved events of such major significance that the " State " had to usurp the usual functions of the civil tribunals, and direct a special law or privilegium against the perpetrator.

While the other major works that came out of Alfonso's workshops, including histories and other prose texts, were in Castilian, the Cantigas are in Galician-Portuguese, and reflect the popularity in the Castilian court of other poetic corpuses such as the cantigas d ' amigo and cantigas d ' amor.

Not only does the ensuing crisis rank with the Berlin Blockade, the Suez Crisis and the Yom Kippur War as one of the major confrontations of the Cold War, it is generally regarded as the moment in which the Cold War came closest to turning into a nuclear conflict, or possibly World War III, where it is estimated that 100 million Americans and over 100 million Russians would have perished.

In 2011, the major story line of John Stape and his murder spree came to an end in May after he jumped off a hospital roof but left before he could be arrested.

In 1930 she was elected a member of the National Institute of Arts and Letters ; in 1933 came membership in the American Academy of Arts and Letters, which two years later organized the first major retrospective of her work.

Core concepts are: ( 1 ) That critical social theory should be directed at the totality of society in its historical specificity ( i. e. how it came to be configured at a specific point in time ), and ( 2 ) That critical theory should improve understanding of society by integrating all the major social sciences, including geography, economics, sociology, history, political science, anthropology, and psychology.

Day's last major hit single came in the UK in 1964 with " Move Over, Darling ", co-written by her son specifically for her.

This prediction came true at least in part: Doom became a major problem at workplaces, both occupying the time of employees and clogging computer networks with traffic caused by deathmatches.

He notes that the order came to Denmark in the latter half of the 12th century and during the next centuries spread to major cities, like Odense, Viborg, Horsens, Ribe and their headquarters in Slagelse, so by the time of the Baltic crusade, the symbol was already a known symbol in Denmark.

The torpedo boat destroyer's first major use in combat came during the Japanese surprise attack on the Russian fleet anchored in Port Arthur at the opening of the Russo-Japanese War on 8 February 1904.

Fubuki class destroyer, UranamiThe next major innovation came with the Japanese Fubuki class or ' special type ', designed in 1923 and delivered in 1928.

McLean's major break came when Mediarts was taken over by United Artists Records thus securing for his second album, American Pie, the promotion of a major label.

Bessel came to the attention of a major figure of German astronomy at the time, Heinrich Wilhelm Olbers, by producing a refinement on the orbital calculations for Halley's Comet.