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A number of harmful and undesired ( adverse ) effects have been observed, including lowered life expectancy, extrapyramidal effects on motor control – including akathisia ( an inability to sit still ), trembling, and muscle weakness – weight gain, decrease in brain volume ( although this is being debated, since schizophrenia, which is often treated with antipsychotics, also causes a shrinkage of brain volume ), enlarged breasts ( gynecomastia ) in men and milk discharge in men and women ( galactorrhea due to hyperprolactinaemia ), lowered white blood cell count ( agranulocytosis ), involuntary repetitive body movements ( tardive dyskinesia ), diabetes, sexual dysfunction, a return of psychosis requiring increasing the dosage due to cells producing more neurochemicals to compensate for the drugs ( tardive psychosis ), and a potential for permanent chemical dependence leading to psychosis worse than before treatment began, if the drug dosage is ever lowered or stopped ( tardive dysphrenia ).
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number and harmful
Although initial studies suggested that antioxidant supplements might promote health, later large clinical trials with a limited number of antioxidants detected no benefit and even suggested that excess supplementation with certain putative antioxidants may be harmful.
Radioactive waste typically comprises a number of radioisotopes: unstable configurations of elements that decay, emitting ionizing radiation which can be harmful to humans and the environment.
The requirement to space these satellites apart to avoid harmful radio-frequency interference during operations means that there are a limited number of orbital " slots " available, thus only a limited number of satellites can be operated in geostationary orbit.
Among them, many parents incorrectly believe that fever is a disease rather than a medical sign, that even low fevers are harmful, and that any temperature even briefly or slightly above the oversimplified " normal " number marked on a thermometer is a clinically significant fever.
Bloodletting slowly lost favour during the 19th century, but a number of other ineffective or harmful treatments were available as placebos — mesmerism, various processes involving the new technology of electricity, many potions, tonics, and elixirs.
Given the number of unpleasant, harmful or even fatal consequences of coming out in world societies, it is questionable to call being closeted a choice.
Anosmia can have a number of harmful effects.
In a number of instances, the revelations of muckraking journalists led to public outcry, governmental and legal investigations, and, in some cases, legislation was enacted to address the issues the writers ' identified, such as harmful social conditions ; pollution ; food and product safety standards ; sexual harassment ; unfair labor practices ; fraud ; and other matters.
Apachean religious stories relate two culture heroes ( one of the Sun / fire :" Killer-Of-Enemies / Monster Slayer ", and one of Water / Moon / thunder: " Child-Of-The-Water / Born For Water ") that destroy a number of creatures which are harmful to humankind.
This tradition combines prescribed foods with a number of restrictions on activities considered to be harmful.
Clinical studies have shown that administering FOS, GOS, or inulin can increase the number of these friendly bacteria in the colon while simultaneously reducing the population of harmful bacteria.
The number of detainees slowly decreased as the less harmful were let out.
< td bgcolor ="# aad686 "> Drugs that have been taken by a large number of pregnant women and women of childbearing age without an increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed .</ td ></ tr >
< td bgcolor ="# aad686 "> Drugs that have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage .</ td ></ tr >
< td bgcolor ="# aad686 "> Drugs that have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals are inadequate or may be lacking, but available data show no evidence of an increased occurrence of fetal damage .</ td ></ tr >
< td bgcolor ="# aad686 "> Drugs that have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans.
Summarizing his 1985 review of studies of a number of new religious movements, such as The Jesus Movement, the Unification Church, the Children of God group in Europe and the Divine Light Mission, James T. Richardson stated that " life in the new religions is often therapeutic instead of harmful ", and suggested that the young people attracted to these movements were affirming their idealism by their involvement.
At different moments in Soviet history a number of research areas were declared " bourgeois pseudosciences ", on ideological grounds, the most notable and harmful cases being these of genetics and cybernetics.
: is necessary to reduce, if not destroy, the tendency of Jewish people to practice a very great number of activities that are harmful to civilisation and to public order in society in all the countries of the world.
Surgery may have a number of undesirable or harmful effects, such as infection, hemorrhage, inflammation, scarring, loss of function, or changes in local blood flow.
Some forms of forest bioenergy have recently come under fire from a number of environmental organizations, including Greenpeace and the Natural Resources Defense Council, for the harmful impacts they can have on forests and the climate.
Carhart stated that he wanted to perform this procedure because he believed it would be safer and would involve fewer risks for the women ; it lowered the risk of leaving potentially harmful fetal tissue in the uterus, and it minimized the number of instruments physicians needed to use.
Lipid A with a reduced number of acyl chains ( for example ; four ) can serve as an inhibitor of immune activation induced by Gram-negative bacteria, and synthetic versions of these inhibitors are in clinical trials for the prevention of harmful effects caused by Gram-negative bacterial infections.
number and undesired
An engineer with a wide knowledge of the design of the system or a system analyst with an engineering background is the best person who can help define and number the undesired events.
Surrogate markers are used when the primary endpoint is undesired ( e. g., death ), or when the number of events is very small, thus making it impractical to conduct a clinical trial to gather a statistically significant number of endpoints.
The disclosure of a person's identity may present a certain number of issues related to privacy and the undesired disclosure of personal information.
number and adverse
There has also been controversy about the role of pharmaceutical companies in marketing and promoting antipsychotics, including allegations of downplaying or covering up adverse effects, expanding the number of conditions or illegally promoting off-label usage ; influencing drug trials ( or their publication ) to try to show that the expensive and profitable newer atypicals were superior to the older cheaper typicals that were out of patent.
Early clinical trials typically enroll a very small number of patients, and the purpose is to identify major safety issues and the maximum tolerated dose, which is the highest dose that does not produce serious or fatal adverse effects.
Mixing hydrocodone with alcohol, cocaine, amphetamines, methylphenidate, benzodiazapines, barbiturates, and a number of other medications can have severe adverse reactions including but not limited to heart failure, heart attack, respiratory distress, pulmonary failure, liver or kidney failure, jaundice, amnesia, seizures, blackouts, and coma.
Each substitution is associated with a number of specific adverse reactions, as well as increased activity against bacterial infections, whereas the quinoline ring, in and of itself, has been associated with severe and even fatal adverse reactions.
Several clinical trials have already reported positive results using rAAV to treat Leber's Congenital Amaurosis, showing that the therapy was both safe and effective There were no serious adverse events, and patients in all three studies showed improvement in their visual function as measured by a number of methods.
After 2 weeks of spread by contact contamination causing an increasing number of adverse health effects, the correct diagnosis of acute radiation sickness was made at a hospital and proper precautions could be put into procedure.
One important disadvantage of PMMA lenses is that no oxygen is transmitted through the lens to the conjunctiva and cornea, which can cause a number of adverse clinical effects.
A disadvantage of these lenses is that they do not allow oxygen to pass through to the cornea, which can cause a number of adverse clinical events.
Treatment may be associated with a number of potentially serious adverse drug reactions ( ADRs ).
Chemicals already shown to have adverse effects in vitro are not currently used in a Draize test, thereby reducing the number and severity of tests carried out.
These practices have been linked to decreases in the average number of drugs in prescriptions, drug costs and incidence of adverse drug events.
Older, poorly designed or poorly managed landfills can create a number of adverse environmental impacts such as wind-blown litter, attraction of vermin, and generation of liquid leachate.
A large number of adverse impacts may occur from landfill operations.
: The direct benefits of the Clean Air Act from 1970 to 1990 include reduced incidence of a number of adverse human health effects, improvements in visibility, and avoided damage to agricultural crops.
Although the rebellion was crushed by the military, it had a number of adverse effects that affected Qasim ’ s position.
As with a number of other spirochetal diseases, adverse pregnancy outcomes are possible with untreated infection ; prompt treatment with antibiotics reduces or eliminates this risk.
Although the efficacy is inconclusive for children over 2 years of age, a number of factors including accidental overdoses and well-documented adverse effects suggested caution in the pediatric prescription of cough syrups and medicines.
James Madison defined a faction as " a number of citizens, whether amounting to a minority or majority of the whole, who are united and actuated by some common impulse of passion, or of interest, adverse to the rights of other citizens, or to the permanent and aggregate interests of the community.
The second was called for by the preference which the common law gave to a distant collateral over the brother of the half-blood of the first purchaser ; the fourth conferred an indefeasible title on adverse possession for twenty years ( a term shortened by Lord Cairns in 1875 to twelve years ); the fifth reduced the number of witnesses required by law to attest wills, and removed the distinction which existed in this respect between freeholds and copyholds ; the last freed an innocent debtor from imprisonment only before final judgment ( or on what was termed mesne process ), but the principle stated by Campbell that only fraudulent debtors should be imprisoned was ultimately given effect to for England and Wales in 1869.
To minimise the risk of long-term adverse effects on target species, by-catch species and marine ecosystems, CCAMLR uses a number of compliance systems to monitor fishing activities in the Convention Area.
A number of herbs are thought to be likely to cause adverse effects.
Due to the number of wheels, the tank could survive losing several without much in the way of adverse effects as well as traversing steeper terrain obstacles.
The most common adverse reaction is nausea, due to a difference in the pH from the body and the pH of the sodium fluorescein dye ; a number of other factors, however, are considered contributors as well.
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