Although single genes have little effect on complex traits and interact heavily both between themselves and with the external factors, research is underway to unravel possible molecular mechanisms underlying anxiety and comorbid conditions.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Although " Takes A Little Time " was a moderate hit single, the album failed to sell like the previous two albums, which had both gone multi-platinum.

Although BR was a single entity, it was divided into six ( later five ) regional authorities in accordance with the existing areas of operation.

Although his success lasted only a year and a half before his death in an airplane crash, Holly is described by critic Bruce Eder as " the single most influential creative force in early rock and roll.

Although there is no strong evidence for any single theory, many independent theories exist, some blaming storms, some capsizing, and some suggesting that wartime enemy activity was to blame for the loss.

" Although based on a simplistic analysis of internal strife in Greece and Turkey, it became the single dominating influence over U. S. policy until at least the Vietnam War.

Although some say Judaism is noncreedal in nature, others say it recognizes a single creed, the Shema Yisrael, which begins: " Hear, O Israel: the LORD our God, the LORD is one.

Although the two parts are now normally published as a single work, Don Quixote, Part Two was a sequel published ten years after the original novel.

Although bacteriophages were first described in 1927, it was only in 1959 that Sinshemer working with phage Phi X 174 showed that they could possess single stranded DNA genomes.

Although the track was edited out of the final cut, it would later be re-recorded and released as " Safe " on the B-side of Bowie's 2002 single " Everyone Says ' Hi '".

Although the single sold poorly, the popularity of Jones's appearance on the show resulted in " Girl " becoming his best remembered solo hit, even though it was not included in the album.

Although many of the results in Elements originated with earlier mathematicians, one of Euclid's accomplishments was to present them in a single, logically coherent framework, making it easy to use and easy to reference, including a system of rigorous mathematical proofs that remains the basis of mathematics 23 centuries later.

Although it never uses the term, The Church of Jesus Christ of Latter-day Saints ( The Mormon Church ) is episcopal, rather than presbyterian or congregational, in the sense that it has a strict hierarchy of leadership from the local bishop up to a single prophet / president, believed to be personally authorized and guided by Jesus Christ.

Although there are important differences between them, all of them were materialists who believed that the world was made up of a single substance, matter, the motions and properties of which could be used to explain all phenomena.

Although its file format also allows for multiple such streams to be concatenated ( zipped files are simply decompressed concatenated as if they were originally one file ), gzip is normally used to compress just single files.

Although turret presses operate much like single stage presses, they eliminate much of the setup time required in positioning individual dies correctly.

" Although it was a single sentence in a 461-page book, reviewers focused on it.

Although the school was a single institution, it was divided into two parts: a grammar school called the collège or schola privata and an advanced school called the académie or schola publica.

Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps.

Although he is often characterized as an " architect " exclusively, as James Beck has observed, " to single out one of Leon Battista's ' fields ' over others as somehow functionally independent and self-sufficient is of no help at all to any effort to characterize Alberti's extensive explorations in the fine arts.

Although they reign under constitutions, the monarchs of Brunei, Oman, Qatar, Saudi Arabia and Swaziland appear to continue to exercise more political influence than any other single source of authority in their nations, either by constitutional mandate or by tradition.

Although the term " metallic bond " is often used in contrast to the term " covalent bond ", it is preferable to use the term metallic bonding, because this type of bonding is collective in nature and a single " metallic bond " does not exist.

Although four songs were released as singles to promote the album ( lead single " Everything I Need ", " Man With Two Hearts ", " Maria ", and " Hard Luck Story "), only the first song charted in the US, and that only at No. 47.

Although they do share commonalities, contemporary Pagan religious movements are diverse and no single set of beliefs, practices, or texts are shared by them all.

Although it was dark as usual I could see that the hall had only recently contained a great many people.

Although New Orleans was not to learn of it for a spell, she also was a sadist, a nymphomaniac and unobtrusively mad -- the perpetrator of some of the worst crimes against humanity ever committed on American soil.

Although Faulkner was the heir in his own family to this tradition, he did not have Stark Young's inclination to romanticize and sentimentalize the planter society.

Although his tender nights were not the ones I dreamed of, nor was it for yachts, sports cars, tall drinks, and swimming pools, nor yet for money or what money buys that I burned, I too was burning and watching myself burn.

Although after much trouble he did manage to get it back, he discovered there was no trade to be had.

Although he did not attend any celebrated schools or universities, he was a master of Greek and Hebrew and could read the Bible in the original.

Although the fort was evacuated in the face of the force of Cornwallis, Morgan and his men did have a chance to take another swing at the redcoats.

Although because of the important achievements of nineteenth century scholars in the field of textual criticism the advance is not so striking as it was in the case of archaeology and place-names, the editorial principles laid down by Stevenson in his great edition of Asser and in his Crawford Charters were a distinct improvement upon those of his predecessors and remain unimproved upon today.

Although Mr. Brown was not himself its inventor ( it was a French idea ), it is typical that his intuition first conceived the importance of mass producing this basic tool for general use.

Although it was a mere fragment of the victim's remains, it was enough.

Although there were only four fluids tested, it was apparent that there were two distinct types.

Although the tape was run for over 1 hr., a steady state was not reached, and it was concluded that the reason for this was that the back pressure of the manometer was built up from the material fed from between the blocks and this was available at a very slow rate.

-- Although there was some variation in results which must be attributed either to trace impurities or to variation in wall effects, the photochemical exchange in the gas phase was sufficiently reproducible so that it seemed meaningful to compare the reaction rates in different series of reaction tubes for the purpose of obtaining information on the effect of chlorine concentration and of carbon tetrachloride concentration on the reaction rate.

Although the Taylor Scale was designed as a group testing device, in this study it was individually administered by psychologically trained workers who established rapport and assisted the children in reading the items.

Although the pause in the advance of general business activity this year has thus far been quite modest, it is hard to escape the conclusion that the softening process will continue into the first quarter of 1961 and possibly somewhat longer.

Although they are not perfectly stable, a relatively modest effort at station keeping can allow a spacecraft to stay in a desired Lissajous orbit for an extended period of time.

Although the Pixies produced relatively few albums, whose sales were modest, they had a significant influence on the alternative rock boom of the 1990s.

Although women were required to wear veils in many churches through at least the 19th century, the resurgence of the wedding veil as a symbol of the bride, and its use even when not required by the bride's religion, coincided with societal emphasis on women being modest and well-behaved.

Although Arafat lived a modest lifestyle, Dennis Ross, former Middle East negotiator for Presidents George H. W.

Although the Spanish takeover of the Louisiana territory ( which was not completed until 1769 ) had only modest repercussions, the British takeover of Spanish Florida resulted in the westward migration of tribes that did not want to do business with the British, and a rise in tensions between the Choctaw and the Creek, historic enemies whose divisions the British at times exploited.

Although it is described as a modest building, the chapel is considered to " complete the ensemble " of the castle.

Although the California Zephyr ran at full capacity and turned a modest profit from its 1949 inception through the late 1950s, by the mid-1960s the train was profitable only during the late spring, summer, and fall.

Although modest economic gains were being made, emigration still continued.

Although ecotourism is intended for small groups, even a modest increase in population, however temporary, puts extra pressure on the local environment and necessitates the development of additional infrastructure and amenities.

Although modest about his own abilities and generous in his praise of other cricketers, Bradman was fully aware of the talents he possessed as a player ; there is some evidence that he sought to influence his legacy.

Although approved for social phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions.

Although they enjoyed only modest success compared to contemporaries such as The Who and The Rolling Stones, Faces have had considerable influence on latter-day rock revivalists.

Although moved by Vaughan's musical prowess, she was attracted to his charmingly modest personality.

Although Sky had received a modest amount of acclaim, including being produced by Rolling Stones producer Jimmy Miller, the band broke up without having any chart success.

Although the original videos were only a modest success outside of Texas, Barney became a major success when the character and format were revamped for the television series and were picked up by the Public Broadcasting Service ( PBS ), debuting as Barney and Friends in 1992.

Although her income was modest during the last years of her life, she was widely honored for her publication of Ulysses and her support of aspiring writers during the 1920s.

Although he was a ruler of modest historical significance, Marko became a major character in South Slavic oral tradition.

Although he directly profited from a number of commercial deals, cattle sales, and land grants, he was modest in his dealings compared with most of his subordinates.

Although of modest size, they are capable of inflicting significant damage: during one study of the threat display, a grey reef shark attacked the researchers ' submersible multiple times, leaving tooth marks in the plastic windows and biting off one of the propellers.

Although boastful by nature, he learns to be more modest as his bragging causes the other children to become irritated.

Although Carleton concentrated most of his modest force at Fort St. Jean, he left small garrisons of British regular army troops at Montreal and Quebec.

Although Cornelius Vanderbilt always occupied a modest home, members of his family would use their wealth to build magnificent mansions.

Although it garnered modest sales, it is among the most successful and recognized arcade shooter ports of the 2000s.

Although inferior in electrical terms to antennas specifically designed for given frequency bands, or optimized for directionality, its all-around performance, relatively modest size, low cost, and the fact that it does not require any complex electronic matching to operate with a standard shortwave transmitter, have made it popular in professional shortwave communications.