Amantadine may be prepared by reacting adamantane with bromine or nitric acid to give the bromide or nitroester at position one.

Amantadine and rimantadine, have been introduced to combat influenza.

Amantadine is frequently used to treat the chronic fatigue often experienced by patients with multiple sclerosis.

Amantadine has been associated with several central nervous system ( CNS ) side effects, likely due to amantadine's dopaminergic and adrenergic activity, and to a lesser extent, its activity as an anticholinergic.

In September, 2006, a WHO scientist announced that studies had confirmed cases of H5N1 strains resistant to Tamiflu and Amantadine.

Amantadine appears to act through several pharmacological mechanisms, but no dominant mechanism of action has been identified.

Amantadine is sometimes used as a psychedelic at doses up to 3 grams.

`` You may have seen me on TV '', she said.

The body may have been two or three weeks' dead.

Something was beginning to stir and come alive in her, too ( it may have been there for a good while, since she was twenty now ; ;

-- liberal considers that the need for a national economy with controls that will assure his conception of social justice is so great that individual and local liberties as well as democratic processes may have to yield before it.

The American liberal may, in the world of to-day, have a strong case ; ;

Accounts have been published of Northern liberals in the South up against segregationist prejudice, especially in state-supported universities where pressure may be strong to uphold the majority view.

Among Bourbons the racial issue may have less to do with their remaining unreconstructed than other factors.

Thus, to cite but one example, the Pax Britannica of the nineteenth century, whether with the British navy ruling the seas or with the City of London ruling world finance, was strictly national in motivation, however much other nations ( e.g., the United States ) may have incidentally benefited.

Jean Bodin, writing in the sixteenth century, may have been the seminal thinker, but it was the vastly influential John Austin who set out the main lines of the concept as now understood.

An example of the changes which have crept over the Southern region may be seen in the Southern Negro's quest for a position in the white-dominated society, a problem that has been reflected in regional fiction especially since 1865.

Looking back, Miss Marsicano feels that her ideas may have been influenced by those of Jackson Pollock.

The conversation that ensued may have been engrossing but it could hardly be called world-shattering.

The consciousness it mirrors may have come earlier to Europe than to America, but it is the consciousness that most `` mature '' societies arrive at when their successes in technological and economic systematization propel them into a time of examining the not-strictly-practical ends of culture.

The part of the mind that preserves dates and events may remonstrate, `` It could have been like that for only a little while '' ; ;

It may, however, be noted that his gift for color and imagery must have been greatly stimulated by his stay in Paris.

Does our society have a runaway, uncontrollable growth of technology which may end our civilization, or a normal, healthy growth??

In any event, whether society may have cancer, or merely a virus infection, the `` disease '', we shall find, is political, economical, social, and even medical.

Any abilities I may have were achieved in their present shape from experience in sharing in the growth and control of my business, coupled with raising my family.

The best gifts of the novelist will be wasted on the reader who is insulated against any surprises the novelist may have in store for him.

He and also Mr. Cowley and Mr. Warren have fallen to the temptation which besets many of us to read into our authors -- Nathaniel Hawthorne, for example, and Herman Melville -- protests against modernism, material progress, and science which are genuine protests of our own but may not have been theirs.

Such activity may or may not have irritated the Kremlin, but it has frequently condemned America to an unnatural defensiveness that has undermined our effort to give leadership to the free world.

I fled, however, not from what might have been the natural fear of being unable to disguise from you that the things about my bridegroom -- in the sense you meant the word `` things '' -- which you had been galvanizing yourself to tell me as a painful part of your maternal duty were things which I had already insisted upon finding out for myself ( despite, I may now say, the unspeakable awkwardness of making the discovery on principle, yes, on principle, and in cold blood ) because I was resolved, as a modern woman, not to be a mollycoddle waiting for Life but to seize Life by the throat.

Moreover, because of the particular blot on your family escutcheon through what may only have been one unbridled moment on your grandmother's part, and because you had the lean-to kitchen and trundle bed of your childhood to outgrow, what you obviously most desired with both your conscious and unconscious person, what you bent your whole will, sensibility, and intelligence upon, was to be a lady.

It is not in business for the purpose of absorbing increased municipal costs no matter how high a purpose that may be ''.

Milk production may be increased by the anti-infective properties of this drug.

Milk production may be increased by the anti-infective properties of this drug.

Micelles can imbibe and hold a considerable amount of oleophilic substances so that the micelle volume may be increased as much as approximately two-fold.

The finding that the concentration of one of these proteases is increased in thyroid glands from TSH-treated animals suggests that this protease may be active in vivo.

( 3 ) in a state of depression, the positive conditioned stimulus may fail to elicit a conditioned reaction but cause an increased synchrony instead of the excitatory desynchronizing ( alerting ) effect on the Aj.

The individual with high anxiety in the structured classroom may approach the learning task with the same increased energy and lowered powers of discrimination.

It seems likely, moreover, that with an increase in the rate of saving in mortgage lending institutions, interest rates on residential mortgages may move somewhat lower through the spring of next year, although the increased ease in residential mortgage lending may occur primarily in other terms than interest rate, e.g., easier downpayment and amortization terms.

His immediate motive for doing this may not have been directly inspired by the Lo Shu, but this measure must inevitably have increased the existing beliefs in the latter's efficacy.

The benefits for the altruist may be increased and the costs reduced by being being more altruistic towards certain groups.

Because CCD imagers are linear, image processing may be used to subtract away the effects of light pollution, which has increased the popularity of astrophotography in urban areas.

In cases where antibacterials have been suggested to affect the efficiency of birth control pills, such as for the broad-spectrum antibacterial rifampicin, these cases may be due to an increase in the activities of hepatic liver enzymes causing increased breakdown of the pill's active ingredients.

It may be the case that increased worldwide communication through radio, television, the Internet and globalization has reduced the tendency to regional variation.

Seeing a sublime view of a landscape may give us a reaction of awe, which might manifest physically as an increased heart rate or widened eyes.

The effect of tolerance means that frequent use of the drug may result in its diminished effect so, when safe to do so, the dosage may need to be increased to maintain effectiveness.

Side-effects may include drowsiness, increased appetite, and weight gain.

* Sodium: increased intake of sodium may be deleterious for arterial hypertension, heart failure and many renal diseases.

* Vasoconstriction ( narrowing of blood vessels ) and vascular smooth muscle hypertrophy ( enlargement ) induced by AII may lead to increased blood pressure and hypertension.

If ADH production is excessive in heart failure, Na < sup >+</ sup > level in the plasma may fall ( hyponatremia ), and this is a sign of increased risk of death in heart failure patients.

Practical tip to screen distances may range from several centimeters to several meters, with increased detector area required at larger to subtend the same field of view.

Ground bay laurel may be substituted for whole leaves, and does not need to be removed, but it is much stronger due to the increased surface area and in some dishes the texture may not be desirable.

However the carcass value of double-muscled animals may be enhanced due to increased dressing yield, lean carcass content, and upgrading of some cuts leading to a higher proportion of higher valued cuts.