Medications associated with gastrointestinal bleeding such as Bortezomib are sometimes monitored by FOBT.

More and more patients survive longer and longer, thanks to stem cell transplant ( with their own or a donor's ) and treatments combining Bortezomib ( Velcade ), Dexamethasone ( corticoid ) and melphalan or cyclophosphamide ( Endoxan ). This seems to maintain the monoclonal peak at a reasonable level.

Bortezomib is used in the treatment of multiple myeloma.

Bortezomib is a proteasome inhibitor.

Bortezomib bound to the core particle in a yeast proteasome.

If an antibody is developed to stabilize a molecule that's similar to an unstable intermediate of another ( potentially unrelated ) reaction, the developed antibody will enzymatically bind to and stabilize the intermediate state, thus catalyzing the reaction.

The atoms in molecules model developed by Richard Bader was developed in order to effectively link the quantum mechanical picture of a molecule, as an electronic wavefunction, to chemically useful older models such as the theory of Lewis pairs and the valence bond model.

BI811283 is a small molecule inhibitor of the Aurora B kinase protein being developed by Boehringer Ingelheim for use as an anti-cancer agent.

As a result of the extensive study and use of this molecule, more than 200 morphine derivatives ( also counting codeine and related drugs ) have been developed since the last quarter of the 19th century.

The molecule ritonavir, marketed as Norvir, was developed as a protease inhibitor and used to target HIV infection.

An alternative approach was developed in 1929 by Friedrich Hund and Robert S. Mulliken, in which electrons are described by mathematical functions delocalized over an entire molecule.

Algorithms have been developed to ensure the same SMILES is generated for a molecule regardless of the order of atoms in the structure.

In 1927 Mulliken worked with Hund and as a result developed his molecular orbital theory, in which electrons are assigned to states that extend over an entire molecule.

Many specialized organic reactions have been developed for disulfides, again mainly associated with the scission of the S-S bond, which is usually the weakest bond in a molecule.

For short-lived isotopes such as < sup > 11 </ sup > C, very rapid synthetic methods have been developed to permit the rapid addition of the radioactive isotope to the molecule.

He developed the concepts of tetravalent carbon atoms linking together to form large molecules, and that the bonding order of the atoms in a molecule can be determined from chemical evidence.

But BMS-204352 ( MaxiPost ) a molecule developed by Bristol-Myers Squibb failed to improve clinical outcome in stroke patients compared to placebo.

In October 2010, ponatinib, a small molecule, oral drug developed by Ariad Pharmaceuticals, was entered into evaluation in a pivotal Phase 2 trial.

In this future, the Soviets have developed a miniaturization technology that can reduce a man to the dimensions of a molecule, or smaller.

A special computational procedure was developed to separate electronic and steric effects of an arbitrary group in the molecule and to reveal their influence on structure and reactivity.

Ranibizumab, a Fab fragment derived from the same parent molecule as bevacizumab, has been developed by Genentech ( by the same scientist Napoleone Ferrara ) for intraocular use.

An NCE is a molecule developed by the innovator company in the early drug discovery stage, which after undergoing clinical trials could translate into a drug that could be a cure for some disease.

Besides in the future becoming an important alternative to organ transplants, hESC are also being used in field of toxicology and as cellular screens to uncover new chemical entities ( NCEs ) that can be developed as small molecule drugs.

The efforts unleashed a multitude of compounds borne from structure-activity relations developed from the tubocurare molecule.

Following research with decamethonium, scientists developed suxamethonium, which is a double acetylcholine molecule that was connected at the acetyl end.

It appears possible to set a lower limit of about Af for the activation energy of the abstraction of a chlorine atom from a carbon tetrachloride molecule by a chlorine atom to form Af radical.

The research group, financed by toothpaste manufacturer Colgate-Palmolive, has designed a molecule called C16G2 that had been proven to kill S. mutans in Petri dishes.

Synapomorphies ( a character that is shared by two or more groups through evolutionary development ) include the presence in the plants of oligosaccharide inulin, a nutrient storage molecule used instead of starch ; and unique stamen morphology.

The term originally came from antibody generator and was a molecule that binds specifically to an antibody, but the term now also refers to any molecule or molecular fragment that can be bound by a major histocompatibility complex ( MHC ) and presented to a T-cell receptor.

( Binding and subsequent trigger of apoptosis by a molecule is termed positive induction, whereas the active repression or inhibition of apoptosis by a molecule is termed negative induction.

TCDD has been described as " perhaps the most toxic molecule ever synthesized by man ".

The advantage of this technique is that total and background absorption are measured with the same emission profile of the same lamp, so that any kind of background, including background with fine structure can be corrected accurately, unless the molecule responsible for the background is also affected by the magnetic field ; the disadvantage is the increased complexity of the spectrometer.

The most investigated example is represented by thin multicrystalline silicon films, where such as the unoriented molecule. An initial amorphous layer was observed in many studies.

A paradox in metabolism is that, while the vast majority of complex life on Earth requires oxygen for its existence, oxygen is a highly reactive molecule that damages living organisms by producing reactive oxygen species.

The new molecule, consisting of two monosaccharides, is called a disaccharide and is conjoined together by a glycosidic or ether bond.

Glucose is mainly metabolized by a very important ten-step pathway called glycolysis, the net result of which is to break down one molecule of glucose into two molecules of pyruvate ; this also produces a net two molecules of ATP, the energy currency of cells, along with two reducing equivalents in the form of converting NAD < sup >+</ sup > to NADH.

then the distribution correctly gives the Maxwell – Boltzmann distribution of gas molecule speeds, previously predicted by Maxwell in 1859.

The copper is removed by bonding to a ligand, which is a large molecule consisting of a number of smaller groups, each possessing a lone electron pair.

Combustion in oxygen is a chain reaction where many distinct radical intermediates participate. The high energy required for initiation is explained by the unusual structure of the dioxygen molecule.

The result is that each Ca < sup > 2 +</ sup > ion released by chemical weathering ultimately removes one CO < sub > 2 </ sub > molecule from the surficial system ( atmosphere, ocean, soils and living organisms ), storing it in carbonate rocks where it is likely to stay for hundreds of millions of years.

It consists of a molecule of galactose | D-galactose and a molecule of glucose | D-glucose bonded by beta-1-4 glycosidic linkage.

The " Circe effect ", coined by the enzymologist William P. Jencks, refers to a scenario where an enzyme lures its substrate towards it through electrostatic forces exhibited by the enzyme molecule before transforming it into product.

Thus, the molecular formula of ethanol may be written in a paper in conformational, three-dimensional, full two-dimensional ( indicating every bond with no three-dimensional directions ), compressed two-dimensional ( CH < sub > 3 </ sub >– CH < sub > 2 </ sub >– OH ), separating the functional group from another part of the molecule ( C < sub > 2 </ sub > H < sub > 5 </ sub > OH ), or by its atomic constituents ( C < sub > 2 </ sub > H < sub > 6 </ sub > O ), according to what is discussed.