By the early 17th century, there were some 500 encomiendas in Ecuador.

By the mid 17th century, numerous small Dutch and Flemish distillers ( some 400 in Amsterdam alone by 1663 ) had popularized the re-distillation of malt spirit or wine with juniper, anise, caraway, coriander, etc., which were sold in pharmacies and used to treat such medical problems as kidney ailments, lumbago, stomach ailments, gallstones, and gout.

By the end of the Roman Empire, having undergone Christian attack and repression, Epicureanism had all but died out, and would be resurrected in the 17th century by the atomist Pierre Gassendi, who adapted it to the Christian doctrine.

By the early 17th century, the island and its smaller neighbors ( notably Tortuga ) became regular stopping points for Caribbean pirates.

By the 17th century, Osei Kofi Tutu I ( c. 1695 – 1717 ), with help of Okomfo Anokye, unified what became the Ashante into a confederation with the Golden Stool as a symbol of their unity and spirit.

By the 17th century, the Maravi Empire encompassed all the area between Lake Malawi and the mouth of the Zambezi River.

By the middle of the 17th century, plays such as Robert Davenport's King John and Matilda, although based largely on the earlier Elizabethan works, were transferring the role of Protestant champion to the barons and focusing more on the tyrannical aspects of John's behaviour.

By the 17th Century, the Medieval teleological view came under intense criticism from some quarters.

By the 17th century, the mechanisms of keyboard instruments such as the clavichord and the harpsichord were well known.

By the end of the 17th century, the Chinese economy had recovered from the devastation caused by the wars in which the Ming Dynasty were overthrown, and the resulting breakdown of order.

By the 17th century the influence of Renaissance painting resulted in Russian icons becoming slightly more realistic, while still following most of the old icon painting canons, as seen in the works of Bogdan Saltanov, Simon Ushakov, Gury Nikitin, Karp Zolotaryov and other Russian artists of the era.

By the 17th century, wooden wagonways were common in the United Kingdom for transporting coal from mines to canal wharfs for transshipment to boats.

By the 17th century, with the growing use of firearms and the accompanying decline in the use of armour, many rapiers and dueling swords had developed elaborate basket hilts, which protect the palm of the wielder and rendered the gauntlet obsolete.

By the 17th century, the city of Skopje had a diverse religious population which included Orthodox Christians, Muslims, Roman Catholics and Jews.

By the later 17th century, however, English dramatists ( under the influence of French criticism picked up by those in exile during the English Interregnum ) did begin to assess their own plays according to these rules.

By the 17th century, water pump designs had improved to the point that they produced measurable vacuums, but this was not immediately understood.

By the start of the 17th century ' jachts ' came in two broad categories-speel-jachts for sport and oorlog-jachts for naval duties.

By the middle of the 17th century the Realm of Sweden had reached its greatest territorial extent and was one of the great powers of Europe.

By the end of the Roman Empire, having undergone Christian attack and repression, Epicureanism had all but died out, and would be resurrected in the 17th century by the atomist Pierre Gassendi, who adapted it to the Christian doctrine.

By means of the slave trade it came to the American continent, probably in the 17th century.

By the late 17th century, however, the Ottoman Empire's military misfortunes caught up with the country, and the conclusion of the Great Turkish War with the Treaty of Karlowitz in 1699 once again made Bosnia the empire's westernmost province.

By the middle of the 17th century the Carmelites had reached their zenith.

By the 1997 – 98 season, Fox had 3 shows in the Nielsen Top 20, The X-Files which ranked 11th, King of the Hill which ranked 15th, and The Simpsons which ranked 17th.

By the late 17th century, the electorate of the three seats comprised the resident freemen of Monmouth, Newport and Usk, and after the Great Reform Act of 1832 the constituency was generally referred to as the Monmouth Boroughs.

By the 17th century, Canterbury's population was 5, 000 ; of whom 2, 000 were French-speaking Protestant Huguenots, who had begun fleeing persecution and war in the Spanish Netherlands in the mid-16th century.

By the end of the nineteenth century, in 1893, when the Big Three, Columbia, and Penn were populous centers of learning, Dartmouth graduated only sixty-nine.

By the end of the century the Roman Catholic Church was beginning to make itself felt, mainly through such institutions as hospitals but also through its attitude towards organized labour.

By the 27th century BC Egyptian writing had a set of some 24 hieroglyphs which are called uniliterals, to represent syllables that begin with a single consonant of their language, plus a vowel ( or no vowel ) to be supplied by the native speaker.

By the tenth century two other forms can be distinguished namely Canaanite and Aramaic.

By the end of the 14th century, most of Anatolia was controlled by various Anatolian beyliks.

By the 6th century BC, the Celtic La Tène culture was well established.

By the mid-19th century scientists began to arrive en masse to study the geology and ecology of the region.

By the late 5th century BC, philosophers might separate Aphrodite into two separate goddesses, not individuated in cult: Aphrodite Ourania, born from the sea foam after Cronus castrated Uranus, and Aphrodite Pandemos, the common Aphrodite " of all the folk ," born from Zeus and Dione.

By the beginning of the 8th century, these kingdoms had either been conquered by Nicene neighbors ( Ostrogoths, Vandals, Burgundians ) or their rulers had accepted Nicene Christianity ( Visigoths, Lombards ).

By the middle of the 19th century, industrialisation swept away most of the city's medieval rules of production and commerce, although the entirely corrupt remains of the city's mediæval constitution was kept in place ( compare the famous remarks of Georg Forster in his Ansichten vom Niederrhein ) until 1801, when Aachen became the " chef-lieu du département de la Roer " in Napoléon's First French Empire.

By the 6th century Alexander's commentaries on Aristotle were considered so useful that he was referred to as " the commentator " ().

By the mid-4th century however the assembly's judicial functions were largely curtailed, though it always kept a role in the initiation of various kinds of political trial.

By the mid-16th century, they were in common use in most of Europe.

By the standards of 19th century tycoons, Carnegie was not a particularly ruthless man but a humanitarian with enough acquisitiveness to go in the ruthless pursuit of money ; on the other hand, the contrast between his life and the lives of many of his own workers and of the poor, in general, was stark.

By the 7th century BC, much of the Assyrian population used Akkadian influenced Eastern Aramaic and not Akkadian itself.

By the 4th century AD artists had started debating in writing over the proper goals of art as well.

By the end of the twentieth century " Negro " had come to be considered inappropriate and was rarely used and perceived as a pejorative.

By the early 5th century Britain had been Roman for over three hundred and fifty years.

By the 1st century BC, Aediles were elected in July, and took office on the first day in January.

By the 16th century, a cappella polyphony had further developed, but gradually, the cantata began to take the place of a cappella forms.

By the 19th century orchestral music in Europe had standardized the string section into the following homogeneous instrumental groups: first violins, second violins, violas, cellos, and double basses.

By the 3rd century BC, the rival armies of Carthage and Rome began to invade and fight for control of the Iberian Peninsula.

By the 5th century AD, Rome was in decline and the Roman predecessor town of Alicante, known as Lucentum ( Latin ), was more or less under the control of the Visigothic warlord Theudimer.

By the end of the 18th century there were no factories or mills and only a few small cottage industries along the border with Zurich.

By the beginning of the twentieth century, Steiner's interests turned to explicitly spiritual areas of research.