PrP < sup > C </ sup > is readily digested by proteinase K and can be liberated from the cell surface in vitro by the enzyme phosphoinositide phospholipase C ( PI-PLC ), which cleaves the glycophosphatidylinositol ( GPI ) glycolipid anchor.

* glypiation, which is the addition of a GPI anchor that links proteins to lipids through glycan linkages.

A special form of glycosylation is the formation of a GPI anchor.

Glycosylphosphatidylinositol () ( GPI anchor ) is a glycolipid that can be attached to the C-terminus of a protein during posttranslational modification.

In PNH a clonal defect in blood stem cells in the gene PIGA, that is required for GPI synthesis, results in faulty GPI linkage of decay-accelerating factor ( DAF ) and CD59 in red blood cells.

The enzyme phosphatidylinositol glycan A ( PIGA ) is needed to make glycosylphosphatidylinositol ( GPI ), a molecule that anchors proteins to the cell membrane.

Another form of C-terminal modification is the addition of a phosphoglycan, glycosylphosphatidylinositol ( GPI ), as a membrane anchor.

The GPI anchor is attached to the C-terminus after proteolytic cleavage of a C-terminal propeptide.

The soundtrack of Mark VII Limited's production logo ( the drum roll and the two clinks of the hammer ) is often used while the GPI / Williams Street production card is shown.

The DivX reader is announced, as well as the GPI, which is a GP32 capable of functioning as a video game console, a cell phone, and a PDA.

The genuine progress indicator ( GPI ) is an alternative metric system which is an addition to the national system of accounts that has been suggested to replace, or supplement, gross domestic product ( GDP ) as a metric of economic growth.

The GPI is used in green economics, sustainability and more inclusive types of economics commonly known as " True Cost " economics.

The GDP vs the GPI is analogous to the difference between the gross profit of a company and the net profit ; the Net Profit is the Gross Profit minus the costs incurred.

The best known attempts to apply the concepts of GPI to legislative decisions are probably the GPI Atlantic indicator pioneered by Ronald Colman for Atlantic Canada, the Alberta GPI pioneered by ecological economist Mark Anielski to measure the long-term economic, social and environmental sustainability of the province of Alberta and the environmental and sustainable development indicators used by the Government of Canada to measure its own progress to achieving well-being goals: its Environment and Sustainable Development Indicators Initiative ( Canada ) is a substantial effort to justify state services in GPI terms.

The GPI indicator is based on the concept of sustainable income, presented by economist John Hicks ( 1948 ).

It is relatively straightfoward to measure compared to GPI.

GPI advocates claim that it can more reliably measure economic progress, as it distinguishes between worthwhile growth and uneconomic growth.

However GDP tends to be reported as synonymous with economic progress by journalists and politicians and the GPI seeks to correct this shorthand by providing a more encompassing measure.

Therefore, opponents of GPI claim that GPI cannot function to measure the goals of a diverse, plural society.

Supporters of GPI would respond that GDP, when used as a measure of societal well-being, ends up defining well-being to be things that the supporters of GDP ideologically support, and cannot function to measure the goals of a diverse, plural society.

Supporters of GDP as a measure of societal well-being claim that competing measures such as GPI are more vulnerable to political manipulation.

GPI takes account of these problems by incorporating sustainability: whether a country's economic activity over a year has left the country with a better or worse future possibility of repeating at least the same level of economic activity in the long run.

The need for a GPI to supplement biased indicators such as GDP was highlighted by analyses of uneconomic growth in the 1980s notably that of Marilyn Waring who studied biases in the UN System of National Accounts.

According to results in 1970s and 1980s the economic growth, measured by GDP, clearly increased the welfare, measured by the GPI.

According to results, the GDP has increased enormously, but at the same time the GPI has stagnated.

Accordingly, the GPI will be zero if the financial costs of crime and pollution equal the financial gains in production of goods and services, all other factors being constant.

In 1997, Lazzo and GPI began production on Toonami, an afternoon block of action cartoons on Cartoon Network.

Proteins with GPI anchors are an exception to this rule and can have purification properties similar to those of integral membrane proteins.

So far GPI time-series have been calculated to USA and Australia as well as to several of their states.

The GPI time-series 1945 to 2011 for Finland have been calculated at the Statistics Finland.

If measured by GPI, the sustainable economic welfare has actually decreased due to environmental hazards that have cumulated to environment.

The Finnish GPI time series have been updated by Dr. Jukka Hoffrén at Statistics Finland.

Within EU's Interreg IV C FRESH Project ( Forwarding Regional Environmental Sustainable Hierarchies )-project GPI time-series have been calculated to Päijät-Häme, Kainuu and South-Ostrobotnia ( Etelä-Pohjanmaa ) regions in 2009-2010.

This later work resulted yet an other macroeconomic indicator Genuine Progress Indicator ( GPI ): see sustainability measurement.

In the same manner, GPI depicts the state of welfare in the society by taking into account the ability to maintain welfare on at least the same level in the future.

The GPI is an extension of ISEW, that stresses genuine and real progress of the society and seeks especially to monitor welfare and the ecological sustainability of the economy.

The ISEW and GPI summarise economic welfare by means of a single figure according to same logic as GDP summarises economic output into a single figure.

Competing measures like GPI define well-being to mean things that the definers ideologically support.

A user still needed three VTRs and a controller to perform A / B roll linear video editing ( LE ), as the Toaster would serve merely as a switcher ( which could be triggered through General Purpose Input / Output ( GPI ) to switch on cue in such a configuration ) but the Toaster itself had no edit controlling capabilities.

Integral and peripheral proteins may be post-translationally modified, with added fatty acid or prenyl chains, or GPI ( glycosylphosphatidylinositol ), which may be anchored in the lipid bilayer.

Other anchors include the GPI anchor.

are accessible only to JSTOR and GPI members.

Some of the GPI concepts ( like viewing transforms ) were later incorporated into Windows NT.

* GPI interface-For sending external alarm triggers.

If a mutation occurs in this gene then PIGA may be defective, which leads to a defect in the GPI anchor.

Several of the proteins that anchor to GPI on the cell membrane are used to protect the cell from destruction by the complement system, and, without these anchors, the cells are more easily targeted by the complement proteins.

* GPI ( Gemini Planet Imager ), built by a consortium of US and Canadian institutions to fulfil the requirements of the ExAOC Extreme Adaptive Optics Coronagraph proposal.

The axon hillock also functions as a tight junction, since it acts as a barrier for lateral diffusion of transmembrane proteins, GPI anchored proteins such as thy1, and lipids embedded in the plasma membrane.