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However, the COX enzymes are expressed constitutively in some areas of the CNS, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness.
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However and COX
However, many aspects of the mechanism of action of NSAIDs remain unexplained, for this reason further COX pathways are hypothesized.
However, the results could be read as showing that paracetamol acts at a different site than the other NSAIDs and that more than one COX isoform contribute to the fever response.
However and enzymes
However, although these enzymes can produce oxidants, the relative importance of the electron transfer chain to other processes that generate peroxide is unclear.
However, enzymes do differ from most other catalysts in that they are highly specific for their substrates.
However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes in the body that can normally break down proteins.
However NO < sub > 3 </ sub > is more abundant so most phytoplankton have adapted to have the enzymes necessary to undertake this reduction ( nitrate reductase ).
However, the recipe using the new enzymes caused the bread to have a different taste and texture, and other market forces like a resurrection of the Atkins diet and competitor Krispy Kreme doughnuts affected pricing and sales volume.
However, it has been shown more recently that, throughout the lifetime of a person, tenocytes in the tendon actively synthesize ECM components as well as enzymes such as matrix metalloproteinases ( MMPs ) can degrade the matrix.
However, x-ray crystallographic studies of both types of enzymes reveal that, other than containing a critical Mg2 + ion at the catalytic site, they are virtually unrelated to each other ; indeed template-dependent nucleotide polymerizing enzymes seem to have arisen independently twice during the early evolution of cells.
However these enzymes are structurally and mechanistically different.
However, unlike many parasitic microbes, Nanoarchaeum has many DNA repair enzymes, as well as everything necessary to carry out DNA replication, transcription, and translation.
However, to compensate for the flaw, Orochimaru devised the Cursed Seals by infusing his Senjutsu Chakra into the enzymes he extracted from Jugo's body.
However switching off these enzymes can also cause abnormal accumulation of glycogen and phospholipids in lysosomes, causing a toxic myopathy.
However HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs.
However it would be wasteful to produce the enzymes when there is no lactose available or if there is a more preferable energy source available such as glucose.
However, as the blood from such a bleed is usually chemically modified by action of acid and enzymes, it presents more commonly as melena.
However, critics point out that enzymes, as with other proteins consumed in the diet, are denatured and eventually lysed by the digestive process rendering them non-functional.
However, tetraphyllin B and epi-tetraphyllin B, cyanogenic glycosides ( which liberate hydrogen cyanide when activated by enzymes ), have been found in the leaves.
However, not all of the markers currently used are enzymes.
However, the enzymes would still need to be replaced after a few years.
However, one of the main problem with this technique was that the metabolic pathway for the production of that metabolite was not analyzed, and as a result, constraints to production and relevant pathway enzymes to be modified were unknown.
However, this venom has been found to contain several enzymes useful for manufacturing drugs in the treatment of diabetes, and research on the pharmacological use of its venom is ongoing.
However, trichomes of S. fimbriatum have been shown to produce digestive enzymes, specifically proteases, like other carnivorous plants.
However, in 1935, Dr. Stewart Baxter showed that the pancreas secretes digestion enzymes simultaneously regardless of whether the food eaten is carbohydrates or protein.
However and are
However, in recent decades, for what doubtless are multiple reasons, an unannounced but nonetheless readily observable shift has occurred in both facets of national activity.
However, in the context of legal and civic policy, these controversies are less than novel.
However, despite the insight of many of his observations, his own conclusions are open to suspicion because of his failure to employ at all times the correct research methods.
However, there are still several types of calls that necessitate the use of telephone operators.
However, he states unequivocally `` the scandals in business are far less significant than the scandals in labor ''.
However, few are taxed, and the owners and location of most boats are unknown to the assessors on the date of assessment of town valuations.
However, the surface temperature gradient can produce erroneous vapor-pressure measurements for the bulk liquid helium unless precautions are taken to isolate the tube ( which passes through the surface to the vapor pressure bulb ) from the liquid helium surface.
However, if their United States income is not subject to the withholding of tax on wages, their returns are due June 15, 1962, if they use a calendar year, or the 15th day of the 6th month after the close of their fiscal year.
However, the aircraft which we have today are tied to large, `` soft '' airfields.
However, some formulas are used more than others.
However, there is also much to be gained by making use of the abilities of the local people who are available and interested in recreation.
However, there are photographs of suspended drops of cyclohexanol phthalate ( viscosity 155 poises ) suspended in corn syrup of 71 poises in a paper by Mason and Bartok.
However, any oxygen nonequivalence would shorten either the already extremely short Af interlayer distance of 2.55 A or the non-hydrogen-bonded Af interlayer interactions which are already quite short at 2.58 Aj.
However, as so many of the records are not certainly based on newborn snakes, these data must be taken tentatively ; ;
However, if these procedures are applied more often, conditioned emotional responses are temporarily abolished.
However, it cannot be presumed, informal though the structure of the population seems, that there are not well-defined roles within the system.
However, the differences in procedure are fundamental.
However, the regionally differentiated results, which appear below in tables, are interesting evidence of the problems of developing self-government under even the most favorable circumstances.
However, if Federal funds are used, it would be entirely appropriate to train workers for jobs which could be obtained elsewhere as well as for jobs in the area of chronic unemployment.
However, it is not known to either the union or the public precisely how much of a cost increase is caused by a given change in the basic wage rate, although the companies are presumed to have reliable estimates of this magnitude.
However, there are relatively few such political constituencies, and, as has been pointed out, there is seldom a clear-cut distinction between the educational interests of one social class and those of another.
However, modesty and triviality are different qualities.
`` However, evidence that the Axis powers are making significant preparations indicative of such an intention is being reported with increasing frequency from a variety of sources.
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