However, gene tests may not detect every mutation associated with a particular condition because many are as yet undiscovered.

However, this assumes that such a mutation is possible.

However, the concept of suppressing mutation raises the question: How can design evolution occur at the nanoscale without a process of random mutation and deterministic selection?

However, if we know an object has only one reference ( as most do in many systems ), and that reference is lost at the same time that a similar new object is created ( as in the string append statement ), we can replace the operation with a mutation on the original object.

However, the heterozygous advantage hypothesis was proposed in one review in which the author himself writes, " Although cellular / molecular evidence presently is not available for this hypothesis, the CF mutation may be one of several mutations that have spread in European populations because they increased resistance to infectious diseases.

However, given the scarcity of fertile androgen insensitive men and low incidence of AR mutation, the chances of this occurrence is small.

However, it is interesting to note that premature menopause is more common in premutation carriers than in women with the full mutation, and for premutations with more than 100 repeats the risk of FXPOI begins to decrease.

However, females with a full mutation are able to pass this full mutation on, so theoretically there is a 50 % chance that a child will be affected.

However, " Gaspé " may instead be a mutation of the Basque word " Gerizpe ", meaning " shelter ".

However, Segerer ( 2010 ), the only classification since Sapir, ties Bijago to the Bak languages, based on previously unrecognized sound correspondences, and separates Bak, the rest of Northern ( Senegambian, defined by consonant mutation ), and Mel as independent branches, and Gola and Limba as Niger – Congo isolates.

However, if a mutation affected younger individuals, selection against it would be strong.

5-10 % of patients with hemophilia A are affected because they make a dysfunctional version of the factor VIII protein ( qualitative deficiency ), while the remainder are affected because they produced factor VIII in insufficient amounts ( quantitative deficiency ).< sup >: 1700 </ sup > Of those who have severe deficiency ( defined as < 1 % activity of factor VIII ), 45-50 % have the same mutation, an inversion within the factor VIII gene that results in total elimination of protein production .< sup >: 1700 </ sup > However, since both forms of hemophilia can be caused by a variety of different mutations, initial diagnosis and classification is done by measurement of protein activity rather than by genetic tests, though genetic tests are recommended for testing of family members once a known case of hemophilia B is identified .< sup >: 1700-1701 </ sup >

However, good functional language compilers will often recognize when an object very similar to an existing one is created and then the old one thrown away, and will optimize this into a simple mutation " under-the-hood ".

However this fast evolution might also be due to these sequences ' inability to repair DNA damage via template-assisted repair which is equivalent to an increase in the mutation rate for these sequences.

However, unlike animal chimeras, both types of tissues may have originated from the same zygote, and the difference is often due to mutation during ordinary cell division.

However, some clones of Pinot Meunier have been found to be completely hairless -- a chimeric mutation, in fact -- which has led ampelographers to more closely draw a link between Meunier and Pinot noir.

However, the difference is subtle and cannot be used to identify the mutation clinically.

However, a study by Negoro et al ( 2006 ) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.

However, few cases of lipoid CAH due to a mutation and defect of P450scc have been identified.

However, even after millions of years of evolution, exploring many sequences with similar function, no mutation might exist that gives this enzyme the ability to catalyze a different reaction.

However, her mind is later completely circumvented by the mutation.

However, the same mutation also conveyed advantages, providing improved viability for heterozygous individuals.

However, the impact of a rising rate of household formation this decade should not be exaggerated.

However, it is not known to either the union or the public precisely how much of a cost increase is caused by a given change in the basic wage rate, although the companies are presumed to have reliable estimates of this magnitude.

However, in late 2006 and early 2007 the rate of attrition reached new proportions, and the term colony collapse disorder was coined to describe the sudden disappearances.

However, the explanation of this curvature involves centrifugal force for all observers with the exception of a truly stationary observer, who finds the curvature is consistent with the rate of rotation of the water as they observe it, with no need for an additional centrifugal force.

However, the law of mass action is valid only for concerted one-step reactions that proceed through a single transition state and is not valid in general because rate equations do not, in general, follow the stoichiometry of the reaction as Guldberg and Waage had proposed ( see, for example, nucleophilic aliphatic substitution by S < sub > N </ sub > 1 or reaction of hydrogen and bromine to form hydrogen bromide ).

However in 2009 GFC, Cambodia's inflation rate had a weak deflation of-0. 7 %.

However, in October 2004, the Cuban government announced an end to this policy: from November US dollars would no longer be legal tender in Cuba, but would instead be exchanged for convertible pesos ( since April 2005 at the exchange rate of $ 1. 08 ) with a 10 % tax payable to the state on the exchange of US dollars cash — though not on other forms of exchange.

However, " unanticipated " inflation leads to lender losses as the real interest rate will be lower than expected.

However the term inhibitor is preferred since they do not work by introducing a reaction path with higher activation energy ; this would not reduce the rate since the reaction would continue to occur by the non-catalyzed path.

However, this should be done in a way and at a rate that does not lead to the long-term decline of biological diversity.

However, the rate of new civil wars had not increased appreciably ; the drastic rise in the number of ongoing wars after World War II was a result of the tripling of the average duration of civil wars to over four years.

However, when the slew rate of the current is not so severe ( e. g. Line frequency ) the effect can be safely ignored.

However, there are other forces changing the rotation rate of the Earth.

However the assumptions used in the appraisal ( especially the equity discount rate and the projection of the cash flows to be achieved ) are likely to be at least as important as the precise model used.

In order for this reaction to occur the power supply should provide at least a potential of 4 V. However, larger voltages must be used for this reaction to occur at a high rate.

However, in the context of explosives, stability commonly refers to ease of detonation, which is concerned with kinetics ( i. e., rate of decomposition ).

However, factors such as forced or non-standard development ( such as bleach bypass or cross processing ), compensation for filters or shutter angle, as well as intended under-and over-exposure may cause the cinematographer to actually " rate " the stock differently from the EI.

However, Slipher discovered that the spiral nebulae had high red shifts, indicating that they were moving away at rate higher than the Milky Way's escape velocity.

However, all 15 councils which initially refused to set a rate eventually did so, and the campaign failed to change Government policy.

However, now, with the use of aggressive therapy as described above, the death rate from thyroid storm is less than 20 %.

However, a " C " speed rating was produced with either a 3. 0 or 3. 5 MHz maximum clock rate, depending on which datasheet is referenced.

However, Stevenson and Wassersug observe that for sustained activity, a work rate of about 1 hp per horse is consistent with agricultural advice from both 19th and 20th century sources.

However, the first English warship to bear the name Resolution was actually the first rate ( built in 1610 and rebuilt in 1641 ), which was renamed Resolution in 1650 following the inauguration of the Commonwealth, and continued to bear that name until 1660, when the name Prince Royal was restored.

However, there are seasonal changes in the molecular-to-atomic ratio of the neutral atmosphere that cause the summer ion loss rate to be even higher.

However, in the second half of the 1980s, rising stock and real estate prices caused the Japanese economy to overheat in what was later to be known as the Japanese asset price bubble caused by the policy of low interest rate by Bank of Japan.