If a receptor tyrosine kinase ( RTK ) is involved in activating the pathway, the isozyme PLC-γ has tyrosine residues that can become phosphorylated upon activation of an RTK, and this will activate PLC-γ and allow it to cleave PIP < sub > 2 </ sub > into DAG and IP < sub > 3 </ sub >.

If the cell does not lose its signal through the ITAM pathway, it will continue down-regulating CD8 and become a CD4 < sup >+</ sup >, single positive cell.

If the current has a direct pathway to the heart ( e. g., via a cardiac catheter or other kind of electrode ), a much lower current of less than 1 mA ( AC or DC ) can cause fibrillation.

If a coagulation factor is part of the contact activation or tissue factor pathway, a deficiency of that factor will affect only one of the tests: Thus hemophilia A, a deficiency of factor VIII, which is part of the contact activation pathway, results in an abnormally prolonged aPTT test but a normal PT test.

* If S < sub > N </ sub > 1 and E1 pathways are competing, the E1 pathway can be favored by increasing the heat.

If disturbed, the pathway provides an obstacle-free escape route.

If the smaller population fragment becomes genetically isolated from the parental group, it may be subjected to its own unique mutations, selection forces, and genetic drift effects ; thus, it will follow its own evolutionary pathway.

If you do not gain direct entry into a degree at UC, you can choose from one of many pathway programs.

If bodies are prepared with separately uniform temperatures, and are then put into purely thermal communication with each other, by conductive or radiative pathways, they will be in thermal equilibrium with each other just when they have the same temperature, and then there will be no net transfer of heat between them ; but if initially they do not have the same temperature, heat will flow from the hotter to the colder, by whatever pathway, conductive or radiative, is available, and this flow will continue until thermal equilibrium is reached and then they will have the same temperature.

If conditions are acidic enough, the acetic acid can be further reacted via the Fischer esterification pathway, but at a much slower pace.

If the axons have myelin sheaths, then the pathway appears bright white because myelin is primarily lipid.

If most or all of the axons lack myelin sheaths ( i. e., are unmyelinated ), then the pathway will appear a darker beige color, which is generally called grey ( British English, or gray in American English ).

If this pathway can be activated in tumor cells using Agkistrodon venom, then theoretically, the proteins in the venom could be used to target and kill cancerous cells.

If you have your sights set on a specific career, an occupational program may be just the right pathway to help you achieve your career goals.

If there is atrial fibrillation with pre-excitation, treatment options include procainamide, flecainide, propafenone, dofetilide and ibutilide since these medications slow conduction in the accessory pathway causing the tachycardia and should be administered before considering electrical cardioversion.

If the foreign molecule is not a protein, then proteolyic digestion can not occur and the T-dependent pathway described above does not operate.

If the third order neuron ( the last of three neurons in the pathway which ultimately discharges norepinephrine into the synaptic cleft ) is intact, then the amphetamine causes neurotransmitter vesicle release, thus releasing norepinephrine into the synaptic cleft and resulting in robust mydriasis of the affected pupil.

If the organism does not contain the complete pathway for the desired product or result, then genes that produce the missing enzymes must be incorporated into the organism.

If there is a black region with only one possible way to connect to the rest of the board, the sole connecting pathway must be black.

If there is a white region that does not contain a number, and there is only one possible way for it to connect to a numbered white region, the sole connecting pathway must be white.

If any part of this pathway is damaged blindness can occur.

If both front and rear surfaces of the device meet this criterion, the light will be ' trapped ' by not having an immediate pathway out of the device due to internal reflections.

If a project does not require approval under Part 3A or Part 4 it is then potentially captured by the third pathway, Part 5 dealing with environment impact assessment.

If the circumstances are faced frankly it is not reasonable to expect this to be true.

If his dancers are sometimes made to look as if they might be creatures from Mars, this is consistent with his intention of placing them in the orbit of another world, a world in which they are freed of their pedestrian identities.

If a work is divided into several large segments, a last-minute drawing of random numbers may determine the order of the segments for any particular performance.

If they avoid the use of the pungent, outlawed four-letter word it is because it is taboo ; ;

If Wilhelm Reich is the Moses who has led them out of the Egypt of sexual slavery, Dylan Thomas is the poet who offers them the Dionysian dialectic of justification for their indulgence in liquor, marijuana, sex, and jazz.

If he is the child of nothingness, if he is the predestined victim of an age of atomic wars, then he will consult only his own organic needs and go beyond good and evil.

If it is an honest feeling, then why should she not yield to it??

If he thus achieves a lyrical, dreamlike, drugged intensity, he pays the price for his indulgence by producing work -- Allen Ginsberg's `` Howl '' is a striking example of this tendency -- that is disoriented, Dionysian but without depth and without Apollonian control.

If love reflects the nature of man, as Ortega Y Gasset believes, if the person in love betrays decisively what he is by his behavior in love, then the writers of the beat generation are creating a new literary genre.

If he is good, he may not be legal ; ;

If the man on the sidewalk is surprised at this question, it has served as an exclamation.

If the existent form is to be retained new factors that reinforce it must be introduced into the situation.

If we remove ourselves for a moment from our time and our infatuation with mental disease, isn't there something absurd about a hero in a novel who is defeated by his infantile neurosis??

If many of the characters in contemporary novels appear to be the bloodless relations of characters in a case history it is because the novelist is often forgetful today that those things that we call character manifest themselves in surface behavior, that the ego is still the executive agency of personality, and that all we know of personality must be discerned through the ego.

If he is a traditionalist, he is an eclectic traditionalist.

If our sincerity is granted, and it is granted, the discrepancy can only be explained by the fact that we have come to believe hearsay and legend about ourselves in preference to an understanding gained by earnest self-examination.

If to be innocent is to be helpless, then I had been -- as are we all -- helpless at the start.

If emission in some directions is blocked by an opaque barrier, the emission would still be approximately one candela in the directions that are not obscured.

* If the offence fumbles ( a ball carrier drops the football, or has it dislodged by an opponent, or if the intended player fails to catch a lateral pass or a snap from centre, or a kick attempt is blocked by an opponent ), the ball may be recovered ( and advanced ) by either team.

He adds " If this highly speculative surmise be correct, it is also necessary to assume either that the existence of the door was forgotten or that the entrance was again blocked with facing stones " in order to explain why al-Ma ' mun could not find the entrance.

If not blocked or countered, the open row of three will be extended to an open row of four, which threatens to win in two ways.

If a clot is large enough to block one or both femoral arteries, there may be hind leg paralysis because the major source of blood flow to the hind leg is blocked.

If D2-blocking drugs are administered the blocked dopamine spills over to the D1 receptors.

If the program rating is outside the level configured as acceptable on that particular television the program is blocked.

If a process requests something for which it must wait, it will be blocked.

* If a process needs to wait for a resource ( wait for user input or file to open ...), it is assigned the " blocked " state.

For example: If one of the threads needs to execute an I / O request, the whole process is blocked and the threading advantage cannot be utilized.

If possible all lines in the manholes except for the line between the manholes are partially blocked.

If the regulator becomes blocked, a safety valve provides a backup escape route for steam.

If however both tubes were completely blocked, so that sperm and egg were physically unable to meet, then fertilization of the egg would naturally be impossible, and neither normal pregnancy nor ectopic pregnancy could occur.

If either of the Nijmegen or Arnhem bridges were not captured and held, the advance of XXX Corps would be blocked and Operation Market Garden would fail.

If Mausolus ' ships blocked a small channel, they could keep all enemy warships out.

If blood can get in, but cannot get out because one of the veins has been blocked, that part of the body turns purple.

If the value becomes negative, the process executing wait () is blocked, i. e., added to the semaphore's queue.

If a user enters a discussion in a chat room and continues to use all capital letters when addressing other users, this action may result in that user being blocked by other participants.

If one failed to win after having blocked two men, then the opponent would gain six points and win the game.

If the escape route for these fluids is blocked, the pore fluid pressure can build up, leading to overpressure.

* If the king should ever have an unimpeded path ( through the neutral zone ) to the edge of the board, unless he is immediately blocked by a Muscovite, he may escape and the game is over.

If a signal was delivered to a process while it was blocked on a long-term I / O in the kernel, then what should be done?

If one part of the circle becomes blocked or narrowed ( stenosed ) or one of the arteries supplying the circle is blocked or narrowed, blood flow from the other blood vessels can often preserve the cerebral perfusion well enough to avoid the symptoms of ischemia.

If the existing lock type does not allow this specific attempted concurrent access type, the transaction attempting access is blocked ( according to a predefined agreement / scheme ).