However, with the use of cre-lox technology, a caspase 8 knock-out has been created that exhibits an increase in peripheral T cells, an impaired T cell response, and a defect in neural tube closure.

DARPA was established during 1958 ( as ARPA ) in response to the Soviet launching of Sputnik during 1957, with the mission of keeping U. S. military technology more sophisticated than that of the nation's potential enemies.

Such cells, tissues and organs would neither trigger an immune response nor require the use of Immunosuppressive drugs Both basic research and therapeutic development for serious diseases such as cancer, heart disease and diabetes, as well as improvements in burn treatment and reconstructive and cosmetic surgery, are areas that might benefit from such new technology.

The choice of switch technology affects key response ( the positive feedback that a key has been pressed ) and travel ( the distance needed to push the key to enter a character reliably ).

Library 2. 0, a term coined in 2005, is the library's response to the challenge of Google and an attempt to meet the changing needs of users by using web 2. 0 technology.

Apart from the usual advantages of modular software with well-defined interfaces, the three-tier architecture is intended to allow any of the three tiers to be upgraded or replaced independently in response to changes in requirements or technology.

The story is told from the viewpoint of the expedition's psychologist, and tries to be ( based on the knowledge then known about Mars when written ) accurate and realistic as to the problems encountered due to the Martian environment, the technology they have, and the human emotional response to their situation.

As android technology improved, bounty hunters had to apply an empathy test — the Voigt-Kampff test — to distinguish humans from androids, by measuring empathetic responses, or lack thereof, from questions designed to evoke an emotional response, often including animal subjects and themes.

While the direct usage of Servlets to generate HTML ( as shown in the example below ) has become rare, the higher level MVC web framework in Java EE ( JSF ) still explicitly uses the Servlet technology for the low level request / response handling via the FacesServlet.

Many updates of film stocks are in response to the improvement of digital video technology.

The simplest way to communicate is through ‘ no technology ’ or " unaided " methods in which the individuals with RTT indicates a response ( i. e., points, blinks their eyes, raises their eyebrows ) to indicate a response.

This spacing was developed in response to problems perceived on the original FM band, mostly due to deficiencies in receiver technology of the time.

The response from MIT faculty and students has been very positive and MIT OpenCourseWare is seen as being consistent with MIT's mission ( to advance knowledge and educate students in science, technology, and other areas of scholarship that will best serve the nation and the world in the 21st century ) and is true to MIT's values of excellence, innovation, and leadership.

In response to the period's political climate and as a form of therapy, Bakshi drew the comic strips Bonefoot and Fudge, which satirized " idiots with an agenda ", and Junktown, which focused on " misfit technology and discarded ideals ".

Since response time, complexity, and capacity are related, the levels may also be distinguished by the controlling technology.

In response to these criticisms, some volunteer-edited directories have adopted wiki technology, to allow broader community participation in editing the directory ( at the risk of introducing lower-quality, less objective entries ).

Shortly thereafter, integrated mapping became a standard and integral part of all CAD systems and continues to evolve alongside 911 response technology.

In response to the E911 challenges inherent to IP phone systems, specialized technology has been developed to locate callers in the case of emergency.

In this respect, information science can be seen as a response to technological determinism, the belief that technology " develops by its own laws, that it realizes its own potential, limited only by the material resources available and the creativity of its developers.

In December 1996, XS4ALL put the Belgrade radio station B92 online using streaming audio technology in response to the jamming of its broadcasts by the regime of Slobodan Milošević.

Interactive voice response ( IVR ) is a technology that allows a computer to interact with humans through the use of voice and DTMF tones input via keypad.

Paintball technology is also used by military forces, law enforcement, para-military and security organizations to supplement military training, riot response, and non-lethal suppression of dangerous suspects.

Advance directives were created in response to the increasing sophistication and prevalence of medical technology.

Such performance is a great tribute to American scientists and engineers, who in the past five years have had to telescope time and technology to develop these long-range ballistic missiles, where America had none before.

More complex assistive technology devices have been developed over time, and as a result, sports for people with disabilities " have changed from being a clinical therapeutic tool to an increasingly competition-oriented activity ".

There are several other initiatives around the world involving humanoid research and development at this time, which will hopefully introduce a broader spectrum of realized technology in the near future.

EveR-1's advanced computing processing power enables speech recognition and vocal synthesis, at the same time processing lip synchronization and visual recognition by 90-degree micro-CCD cameras with face recognition technology.

Of course, the current state of technology at any given time can put limitations on what can be achieved experimentally and theoretically so it may take considerable time for theory to be refined.

This machine was built using materials and engineering tolerances that would have been available to Babbage, quelling the suggestion that Babbage's designs could not have been produced using the manufacturing technology of his time.

The director of the company was interested in Microprocessor technology and noticed there was a market for selling kits to computer building amateurs, so they started selling electronic kits to hobbyists, and employed four persons at that time.

When analog television was developed, no affordable technology for storing any video signals existed ; the luminance signal has to be generated and transmitted at the same time at which it is displayed on the CRT.

In the East, however, it was seen as a way to avoid having to maintain an anti-missile technology race at the same time as maintaining a missile race.

The use of letter " i " prefixes and suffixes to denote information technology or interactivity was very much in vogue at this time, notably with the launch of the iMac and the iPod by Apple Computer ; according to the BBC, the " i " in BBCi stood for " interactivity " as well as " innovation ".

The overall period is characterized by the full adoption of bronze in many regions, though the place and time of the introduction and development of bronze technology was not universally synchronous.

According to Blair ( 1997 ) British Steel faced serious problems at the time of its formation, including obsolescent plants ; plants operating under capacity and thus at low efficiency ; outdated technology ; price controls that reduced marketing flexibility ; soaring coal and oil costs ; lack of capital investment funds ; and increasing competition on the world market.

This time the Italians employed vastly superior military technology such as tanks and aircraft, as well as chemical warfare, the Ethiopian forces were soundly defeated by May 1936.

Over time the forms of and ideas about communication have evolved through progression of technology.

The Soviets, who at the time were well behind the West in jet technology, reverse-engineered the Nene, and installed their own version in the MiG-15 interceptor, used to good effect against US-UK forces in the subsequent Korean War, as well as in several later MiG models.

William Aspdin's innovation was counterintuitive for manufacturers of " artificial cements ", because they required more lime in the mix ( a problem for his father ), a much higher kiln temperature ( and therefore more fuel ), and the resulting clinker was very hard and rapidly wore down the millstones, which were the only available grinding technology of the time.

Construction of a map in real time, for example by using Field-Map technology, improves productivity and quality of the result.

At the same time, the advent of fibre-optic technology enabled companies to extend their systems to nearby towns and villages that by themselves were not viable cable television markets.

All of the logic functions of a calculator had been squeezed into the first " Calculator on a chip " integrated circuits in 1971, but this was leading edge technology of the time and yields were low and costs were high.

In 2003, TFT-LCDs outsold CRTs for the first time, becoming the primary technology used for computer monitors.

Modules were part of DEC's product line into the 1970s, although they went through several evolutions during this time as technology changed.

Some of Flaherty's staging, such as building a roofless igloo for interior shots, was done to accommodate the filming technology of the time.

Aft of the crew spaces was as much engine space as the technology of the time would allow: several boilers and engines or turbines.

Until recently this prevented the technique from being more widely adopted, but software emulations of rythmo band technology overcome the disadvantages of the traditional rythmo band process and significantly reduce the time needed to prepare a dubbing session.