Large-scale production resulted from the development of deep-tank fermentation by chemical engineer Margaret Hutchinson Rousseau.

Large-scale production began in 1890.

) Large-scale production of new characters in this line ended with the onset of Generation 2.

Large-scale production of MDF began in the 1980s, in both North America and Europe.

Large-scale production of the weapon was from 1921-1930.

Large-scale production tragic Democratic dell ' Atene there remained only a few plays of three authors: Aeschylus, Sophocles and Euripides.

Large-scale wall-paintings were apparently much less regarded, relatively crudely executed, and rarely mentioned in contemporary sources ; they were probably seen as a cheap but inferior substitute for mosaic, which in this period must be treated as a fine art, though in recent centuries contemporary production has tended to be seen as decorative.

Large-scale production began in 1934, and in the same year the factory was put under NKVD control and Makarenko was fired.

Large-scale sheep farming, wool production and weaving were the mainstay of Helmsley ’ s economy for several centuries.

Large-scale composting systems are used by many urban areas around the world.

Large-scale structures are very long arcs which can cover over a quarter of the solar disk but contain plasma less dense than in the coronal loops of the active regions.

Large-scale and medium-scale industries are concentrated in North Jakarta.

Large-scale petrol-mechanical and petrol-hydraulic models are available but unusual and pricier than the electrically powered versions.

Large-scale use of chemicals for cotton cultivation, inefficient irrigation systems, and poor drainage systems are examples of the conditions that led to a high filtration of salinized and contaminated water back into the soil.

Large-scale terrestrial impacts of the sort that produced the Barringer Crater, locally known as Meteor Crater, northeast of Flagstaff, Arizona, are rare.

Large-scale West Indian immigration over the last century has also decreased the number of Black Bermudians who are multi-racial, and hardened attitudes.

Large-scale projects to support willow as an energy crop are already at commercial scale in Sweden, and in other countries, others are being developed through initiatives such as the Willow Biomass Project in the US and the Energy Coppice Project in the UK.

Large-scale sculptures of the type characteristic of cult images are also to be found in the collection, including Jupiter and Neptune, as well as various mythological reliefs, among them the Bacchic Altar, a Neo-Attic work of the late Hellenic period, and the Sarcophagus with the Story of Achilles and Polyxena.

Large-scale pieces such as De Staat ( 1972 – 76 ), for example, are influenced by the energy of the big band music of Count Basie and Stan Kenton and the repetitive procedures of Steve Reich, both combined with bright, clashing dissonances.

Large-scale grain receival, storage and logistics operations are known in Australia as bulk handling.

Large-scale pre-planning and extensive project scheduling are replaced by smaller experiments, which can be rapidly adapted as new improvements are suggested.

Large-scale resemblances in plotting — the missing prince, the ruler and his heir who fall in love with the same woman — could be explained through derivation from common sources ; but these larger-scale elements are supported by specific lines and passages that occur in both plays.

With the advance of Large-scale sequencing strategies, genomes of microorganisms in the acid mine drainage community are directly sequenced from the environment.

Large-scale sound reinforcement systems are designed, installed, and operated by audio engineers and audio technicians.

Large-scale empirical models of this type, including the Wharton model, are still in use today, especially for forecasting purposes.

Large-scale systems are able to be calculated by this method.

Large-scale sculptures are installed on the first floor.

Large-scale updates / expansions known as " Chronicles " are done every six months, which introduce new story elements as well as new features and add-ons.

Large-scale charts often cover approaches and entrances to harbours, medium-scale charts cover heavily used coastal areas, and small-scale charts are for navigation in more open areas.

Large-scale deforestation in China would have continued if not for the 11th century innovation of the use of coal instead of charcoal in blast furnaces for smelting cast iron.

Large-scale introduction of fighter planes caused nearly half of the planned bombings to end in failure.

Large-scale commercial hunting of Indian crocodilians for their skin began towards the end of the 19th century, and by the 1970s, crocodile populations were severely depleted.

Large-scale emigration, principally to the United States, and Canada ( predominantly to Quebec, with other areas of the country )-but also to Cuba, other areas of Europe and the Americas such as France ( with French Guiana ), Spain, Belgium, the United Kingdom and Ireland ; and Venezuela, the Dominican Republic, the Bahamas and other Caribbean neighbors-has created what Haitians refer to as the Eleventh Department or the Diaspora.

* November 21 – Large-scale Bleeding Kansas violence begins with events leading to the Wakarusa War between antislavery and proslavery forces.

* Armenia: Large-scale Armenian rebellion against Muslim rule breaks out with Byzantine support.

Large-scale industrialization began in 1954 with the arrival of a General Motors assembly plant.

Large-scale laser systems can produce Q-switched pulses with energies of many joules and peak powers in the gigawatt region.

Large-scale development of Kowloon began in the early 20th century, with the construction of the Kowloon-Canton Railway and the Kowloon Wharf, but due to Kowloon's close proximity to Kai Tak Airport, building construction was limited by flight paths.

Large-scale immigration of Chinese began seventy years later with the advent of the Fraser Canyon Gold Rush of 1858.

Large-scale development began in February 1950 with the construction of the Southdene neighbourhood, with the first houses finished in 1952, the 5, 000th in 1956 and the 10, 000th in 1961.

Large-scale habitat destruction and fragmentation has undoubtedly been important, and may well be the major factor, although there is some evidence that suggests the birds clearly favours agricultural land with patches of remnant native vegetation over intact areas of vegetation.

Large-scale demolition took place along the line of the motorway ( which is still evident today ), tied in with the widening of the Belle Vue and Reddish Lane junctions.

Large-scale excavations were conducted at various times between 1930 and 1937 by Homer Thompson, in collaboration first with K. Kourouniotes and later with Robert Scranton.

Large-scale Japanese immigration to the United States began early in the 20th century, and traditional music came with them.

) Large-scale interplanetary travel is now commercially viable with muon-catalyzed fusion-powered spacecraft.

Large-scale manufacturers can effectively bargain with suppliers for discounts on materials.

Large-scale commercial development began with Colony Square, the first mixed-use development in the Southeast, which was built between 1969 and 1973.

Large-scale warfare resumed with the War of the Austrian Succession ( 1740 – 1748 ).

Large-scale development commenced with the arrival of the Southern Pacific Railroad in 1875, with numerous electric streetcar lines being laid over the following three decades to connect the area to fast-growing Downtown Los Angeles.