Large-scale production resulted from the development of deep-tank fermentation by chemical engineer Margaret Hutchinson Rousseau.

Large-scale construction for multifaceted retirement communities is a new phase of industrial development.

Large-scale suburban development occurred in the 1950s and 1960s, similar to in nearby Pleasure Ridge Park.

Large-scale commercial development is concentrated along the Interstate 494 corridor.

Large-scale use for irrigation began in the 1930s and continued through the 1950s, due to the availability of electric power to rural farming communities and the development of cheap and efficient electric turbine pumps.

Large-scale residential development began when J. C. Long bought up most of the island and built low-cost housing for World War II veterans.

Large-scale development occurred along Range Line Road, particularly around Northpark Mall.

Large-scale development of Kowloon began in the early 20th century, with the construction of the Kowloon-Canton Railway and the Kowloon Wharf, but due to Kowloon's close proximity to Kai Tak Airport, building construction was limited by flight paths.

Large-scale development began in February 1950 with the construction of the Southdene neighbourhood, with the first houses finished in 1952, the 5, 000th in 1956 and the 10, 000th in 1961.

Large-scale commercial development began with Colony Square, the first mixed-use development in the Southeast, which was built between 1969 and 1973.

Large-scale residential development is in progress, however, at Brockworth, on the other side of the M5 motorway, linked from Abbeymead Avenue by Lobleys Drive.

Large-scale development of the area started in 1931, when the Bristol Corporation built 1, 500 houses to the north of Southmead Road, partly to house families cleared from the slums of central Bristol, and partly to address the housing shortage at the time.

Large-scale mining commenced in 1893 under the auspices of the Dominion Coal Company ( DOMCO ) which merged these independent mines.

* 1526 ( Daiei 6, 12th month ): Large-scale mining operations commenced at the Iwami Ginzan Silver Mine in what is now Shimane prefecture.

Large-scale building commenced in the mid-1950s by the Corporation of Glasgow, replacing farms and country estates, to provide housing for city residents living in sub-standard accommodation in the city.

Large-scale emigration, principally to the United States, and Canada ( predominantly to Quebec, with other areas of the country )-but also to Cuba, other areas of Europe and the Americas such as France ( with French Guiana ), Spain, Belgium, the United Kingdom and Ireland ; and Venezuela, the Dominican Republic, the Bahamas and other Caribbean neighbors-has created what Haitians refer to as the Eleventh Department or the Diaspora.

Large-scale dealing, production, import and export are prosecuted to the fullest extent of the law, even if it does not supply end users or coffeeshops with more than the allowed amounts.

* November 21 – Large-scale Bleeding Kansas violence begins with events leading to the Wakarusa War between antislavery and proslavery forces.

* Armenia: Large-scale Armenian rebellion against Muslim rule breaks out with Byzantine support.

Large-scale industrialization began in 1954 with the arrival of a General Motors assembly plant.

Large-scale laser systems can produce Q-switched pulses with energies of many joules and peak powers in the gigawatt region.

) Large-scale production of new characters in this line ended with the onset of Generation 2.

Large-scale immigration of Chinese began seventy years later with the advent of the Fraser Canyon Gold Rush of 1858.

Large-scale sculptures of the type characteristic of cult images are also to be found in the collection, including Jupiter and Neptune, as well as various mythological reliefs, among them the Bacchic Altar, a Neo-Attic work of the late Hellenic period, and the Sarcophagus with the Story of Achilles and Polyxena.

Large-scale pieces such as De Staat ( 1972 – 76 ), for example, are influenced by the energy of the big band music of Count Basie and Stan Kenton and the repetitive procedures of Steve Reich, both combined with bright, clashing dissonances.

Large-scale habitat destruction and fragmentation has undoubtedly been important, and may well be the major factor, although there is some evidence that suggests the birds clearly favours agricultural land with patches of remnant native vegetation over intact areas of vegetation.

Large-scale demolition took place along the line of the motorway ( which is still evident today ), tied in with the widening of the Belle Vue and Reddish Lane junctions.

Large-scale excavations were conducted at various times between 1930 and 1937 by Homer Thompson, in collaboration first with K. Kourouniotes and later with Robert Scranton.

Large-scale Japanese immigration to the United States began early in the 20th century, and traditional music came with them.

) Large-scale interplanetary travel is now commercially viable with muon-catalyzed fusion-powered spacecraft.

Large-scale resemblances in plotting — the missing prince, the ruler and his heir who fall in love with the same woman — could be explained through derivation from common sources ; but these larger-scale elements are supported by specific lines and passages that occur in both plays.

Large-scale manufacturers can effectively bargain with suppliers for discounts on materials.

Large-scale warfare resumed with the War of the Austrian Succession ( 1740 – 1748 ).

Large-scale American support began during the Kennedy Administration in the early 1960s, with the arrival of large numbers of the U. S. Special Forces to help out in the field.

Large-scale upwelling is also found in the Southern Ocean.

Large-scale slate operations required construction of the Monson Railroad in 1883 ; and two foot gauge locomotives transported slate and passengers to the larger Bangor and Aroostook Railroad in Abbot until 1943.

Large-scale industrialization caused many laborers to move from rural to urban areas, which required the construction of numerous pre-fabricated apartment buildings such as this one in Sofia

Large-scale closures of branch railway lines began in the 1960s and 1970s.

Large-scale rail preservation in New Zealand got underway in the 1960s when many steam locomotives were withdrawn and branch lines closed.

Large-scale wildebeest migration is quite likely a consequence of decisions being made by individuals at multiple spatial scales, involving a balance of food abundance, food quality, local density of other wildebeest, social interactions, surface water, perceived predation risk, and culturally ( or possibly genetically ) learned routes and ranges.

Large-scale projects to support willow as an energy crop are already at commercial scale in Sweden, and in other countries, others are being developed through initiatives such as the Willow Biomass Project in the US and the Energy Coppice Project in the UK.