Long-term use of benzodiazepines has been associated with increased risk of cognitive impairment, but its relationship with dementia remains inconclusive.

Long-term use of oral contraceptives with highly potent progestins can also induce endometrial atrophy.

Certain lesions require Long-term video-EEG monitoring with the use of intracranial electrodes if noninvasive testing was inadequate to identify the epileptic focus or distinguish the surgical target from normal brain tissue and function.

Long-term use is associated with hypomagnesemia.

Long-term use of PPIs has been less studied than short term use.

Long-term use of laudanum in nonterminal diseases is discouraged due to the possibility of drug tolerance and addiction.

Long-term use can also lead to abnormal liver function tests ; specifically, prolonged morphine use can increase ALT and AST blood serum levels.

According to Medline Plus, " Long-term use betel-areca preparations has been associated with oral submucosal fibrosis ( OSF ), pre-cancerous oral lesions and squamous cell carcinoma.

Long-term use of alcohol is associated with a decrease in NREM stage 3 and 4 sleep as well as suppression of REM sleep and REM sleep fragmentation.

Long-term use can precipitate the following effects: negative impact on liver function, permanent tooth darkening ( of a greenish tinge ), susceptibility to ulcers, and diminished sex drive.

Long-term ( over 5 years ) use of contact lenses may " decrease the entire corneal thickness and increase the corneal curvature and surface irregularity.

Long-term use of improperly sized shoes can cause misalignment of toes, as well as other orthopedic problems.

Long-term research on greywater use on soil has not yet been done and it is possible that there may be negative impacts on soil productivity.

Long-term use should be avoided in patients with clinical depression as it may worsen mental state.

Long-term use is not recommended, since these agents lose effectiveness after a few days.

Long-term use has been reported to result in addiction.

Long-term use of beta-carotene, vitamin A, and vitamin E supplements may shorten life, with the additional risk being particularly large in smokers.

Long-term use of benzodiazepines can worsen underlying anxiety, with evidence that reduction of benzodiazepines can lead to a lessening of anxiety symptoms.

Long-term use of NSAIDs can cause gastric erosions, which can become stomach ulcers and in extreme cases can cause severe haemorrhage, resulting in death.

Long-term use of the ketogenic diet in children increases the risk of retarded growth, bone fractures and kidney stones.

* Long-term storage and retrieval ( Glr ) is the ability to store information and fluently retrieve it later in the process of thinking.

Long-term memory ( LTM ) is memory in which associations among items are stored, as part of the theory of a dual-store memory model.

Long-term memory, unlike short-term memory, is dependent upon the construction of new proteins.

Long-term hospitalization is uncommon since deinstitutionalization beginning in the 1950s, although it still occurs.

Long-term integrity of the compact reactor pressure vessel is maintained by providing an internal neutron shield.

* Long-term potentiation ( LTP ), the putative cellular mechanism of learning and memory, is first observed by Terje Lømo in Oslo, Norway.

Long-term coevolution sometimes leads to a relatively stable relationship tending to commensalism or mutualism, as, all else being equal, it is in the evolutionary interest of the parasite that its host thrives.

" Long-term commitment to new learning and new philosophy is required of any management that seeks transformation.

" Long-term wear of rigid contact lens is associated with decreased corneal keratocyte density and increased number of epithelial Langerhans cells.

Long-term investors would be well advised, individually, to lower their exposure to the stock market when it is high, as it has been recently, and get into the market when it is low.

Long-term scheduling is also important in large-scale systems such as batch processing systems, computer clusters, supercomputers and render farms.

The Long-term Ecological Observatory is a project off the coast of New Jersey, USA, which monitors the processes in the ocean with online IT systems, spearheaded by the Institute of Marine and Coastal Sciences at Rutgers University.

Long-term interactivity is quite important for a sense of reality as the user would think that he has some lasting influence on the pet.

Long-term effects of benzodiazepines include tolerance, dependence, a benzodiazepine withdrawal syndrome, red eye, and cognitive impairments which may not completely reverse after cessation of treatment ; however, for most patients, cognitive impairment is not severe.

Long-term PN is occasionally used to treat people suffering the extended consequences of an accident, surgery, or digestive disorder.

Long-term mean precipitation by monthIn meteorology, precipitation ( also known as one of the classes of hydrometeors, which are atmospheric water phenomena ) is any product of the condensation of atmospheric water vapor that falls under gravity.

Long-term follow up is required as pterygium may recur even after complete surgical correction.

Long-term clinical observation has shown that the mechanism is not due to a progressive lesion, given that interruption of stimulation reverses its effects.

Long-term potentiation ( LTP ) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.

Long-term inpatient stays are now less common due to deinstitutionalization, although these can still occur.

For housing prices and bankruptcy rates, the experience of Alberta in particular is contrasted to the other regions of the country in an attempt to see whether the problems experienced due to the early 1980s recession were worse in Alberta perhaps due to the NEP. Long-term oil prices, 1861-2007 ( top line adjusted for inflation ).

Long-term treatment of hypoparathyroidism is with vitamin D analogs and calcium supplementation may be ineffective in some due to potential renal damage.

Long-term abuse to the shoulder joint may limit range of motion and productivity due to daily wear and tear of the muscles.

Mortality is usually due to heart failure, pneumonia, respiratory distress syndrome or renal failure and is around 5 %. Long-term follow-up studies are scanty so the long-term effects of argemone oil toxicity have not been documented.

Long-term storage of wood-gas, except through the use of a gasholder-type water-displacement apparatus, should not be attempted, due to the volatile elements present in the gas, which, if allowed to excessively precipitate, will condense in the storage vessel.

Long-term use of such medications must be closely monitored, however, due to the discomforting, and potentially debilitating and life-threatening side-effects.