Maprotiline is used in the treatment of depression, such as depression associated with agitation or anxiety and has similar efficacy to the antidepressant drug moclobemide.

Maprotiline has no known potential for abuse and psychological dependence.

Maprotiline has a wide range of possible interactions.

Withdrawal symptoms frequently seen when treatment with maprotiline is stopped abruptly ( agitation, anxiety, insomnia, sometimes activation of mania or rebound depression ) are not indicative of addiction and can be avoided by reducing the daily dose of Maprotiline gradually by approximately 25 % each week.

Some are typical for tri -/ tetracyclic antidepressants, others are caused by specific metabolic effects ( e. g. high plasma-protein-binding ) of Maprotiline:

Patients with suicidal thoughts, or those with previous suicidal attempts, should be monitored closely under treatment with Maprotiline.

** Maprotiline ( Deprilept, Ludiomil, Psymion )

Maprotiline ( sold as Deprilept, Ludiomil, Psymion ) is a tetracyclic antidepressant ( TeCA ).

** Tetracyclic Antidepressants ( TeCAs ): Amoxapine, Maprotiline.

The pharmacologic profile of Maprotiline explains its antidepressant, sedative, anxiolytic, and sympathomimetic activities.

Maprotiline does not improve mood in nondepressed persons.

Maprotiline should be used during pregnancy only if needed.

Maprotiline should not be given to nursing mothers.

Maprotiline causes a strong initial sedation ( first 2 to 3 weeks of therapy ) and is therefore indicated to treat agitated patients or those with suicidal risks.

It is not known if Maprotiline shares this risk, so cautionary measures are recommended.

Maprotiline may worsen psychotic conditions like schizophrenia and should be given with caution.

* Drugs, which induce certain enzymes in the liver, e. g. Barbiturates, Phenytoin, Carbamazepine and oral anticonceptive drugs, enhance the elimination of Maprotiline and decrease its antidepressant effects.

* The concomitant use of Maprotiline and neuroleptics can lead to increased Maprotiline blood-levels and to seizures.

Combining Maprotiline and Thioridazine could induce severe arrhythmias.

* Additionally, increased blood-levels of Maprotiline are possible, if certain beta-blocking agents ( e. g. Propranolol ) are given concomitantly.

Often it is recognized that all the details of the pattern may not be essential to the outcome but, because the pattern was empirically determined and not developed through theoretical understanding, one is never quite certain which behavior elements are effective, and the whole pattern becomes ritualized.

Being somewhat delicate in health, at the age of sixteen he was sent to Southern Europe, for which he at once developed a passion, so that he spent nearly all of the following ten years abroad, at first in Italy, then in Greece, Egypt, Asia Minor, and Palestine.

The portrait that had developed, fragmentarily but consistently, was the portrait of a man to whom serious thinking is alien enough that the making of a decision inhibits, when it does not forestall, any ability to review the decision in the light of new evidence.

A prototype which fulfills the requirements was developed and thoroughly tested.

While there are now allegations of the withholding of `` favorable evidence developed at the hearing '' and a denial of a `` full and fair hearing '', no such claim was made by petitioner at any stage of the administrative process.

He was an ardent champion of the Brown & Sharpe Apprentice Program and personal counselor to countless able men who first developed their industrial talents with the company.

A project for the Air Force has been completed in which the NAIR infrared detecting device was developed for area monitoring of noxious or dangerous gases.

Except for a rich friendship with the painter, Chauncey Ryder who gave him the only professional instruction he ever had -- and this was limited to a few lessons, though the two artists often went on painting trips together -- Roy developed his art by himself.

Together they also developed a new form of voltaic cell in which the wooden trough was replaced by one of copper, thereby producing stronger currents.

Of interest is a recent announcement by Du Pont's Polychemicals Dept. of a new methyl methacrylate monomer designated as Monocite H 100, which was developed specifically for production of cast acrylic sheets for the sign and lighting industry.

In September, 1958, the patient developed generalized weakness and fatigue which was concurrent with exacerbation of his anemia ; ;

The same system, with minor modifications, was developed in Ruanda-Urundi under Belgian administration.

An objective scale was developed for rating school neighborhoods from these data.

Final ratings were made on the basis of a point system which was developed after studying the distributions of actual behaviors recorded and assigning weight values to each type of behavior that was deviant from the discovered norms.

Recently, for example, a paranoid woman's large-scale philosophizing, in the session, about the intrusive curiosity which has become, in her opinion, a deplorable characteristic of mid-twentieth-century human culture, developed itself, before the end of the session, into a suspicion that I was surreptitiously peeking at her partially exposed breast, as indeed I was.

Much which was in embryo in 1000 had become reasonably well developed by 800.

Greek civilization was swirling toward its great revolution, in which the developed qualities of the Hellenic outlook were suddenly to break forth.

Hardy's two productive decades were separated by forty years, yet between them he developed only in that he became more steadily himself -- it was a narrowing, not an expanding process.

What Parker and his contemporaries -- Gillespie, Davis, Monk, Roach ( Tristano is an anomaly ), etc. -- did was to absorb the musical ornamentation of the older jazz into the basic structure, of which it then became an integral part, and with which it then developed.

the verse of Beowulf or of The Iliad and The Odyssey was not easy to create but was not impossible for poets who had developed their talents perforce in earning a livelihood.

The major contributor was a shopping center with houses being added to the system as the subdivision developed.

special equipment required for registering respiration and for recording the contraction of smooth muscles under various conditions was developed by the Instruments Section ( Victor Jackman, W. C. Barnes, J. F. Reiss ) ; ;