A theoretical synthesis in 2000 suggested the following mechanism: thalidomide intercalates ( inserts itself ) into DNA in guanine-cytosine-rich regions .< ref > Owing to its glutarimide part, ( S ) thalidomide fits neatly into the major groove of DNA at purine sites.

Owing in part to the lack of a definitive narrative outlining its rationale, proponents offered divergent or seemingly conflicting viewpoints.

Owing in part to the different countries in which the lyricist and composers resided, recording on the album musical of Chess began in Stockholm in early November 1983, with Andersson recording the many layered keyboard parts himself along with other basic work at their usual Polar Studios.

Owing to his father's work around the globe Pierre was part of the original jetset, and claims that constant travel took its toll on his academic life, though he was always able to draw and paint, and was published as a cartoonist while still in his early teens.

Owing in large part to the results of research and activism by this group, the Official Languages Act was passed in 1969.

# Owing, in part, to abuses of this system ( especially for patronage ), there was enormous resentment of the Church, taking the various forms of atheism, anticlericalism, and anti-Catholicism.

Owing in part to the influence of his mentor, Sir Robert Woods, Gogarty had decided to specialize in otolaryngology, and in Vienna he studied under Ottokar Chiari, Markus Hajek, and Robert Bárány.

Owing to the widespread use of the Textus Receptus ( TR ) as the principal source-language text for Bible editions, the comma is also contained in most translations published from 1522 until the latter part of the nineteenth century.

Owing in part to their vast size, abyssal plains are currently believed to be a major reservoir of biodiversity.

Owing to the continuation of a Gaelic way of life in the north of the county, Oldcastle suffered far more than the richer more arable land in the southern part of County Meath.

Owing in part to the fact that the Roman cities were far larger than the Greek city-states in power and population, and generally less provincial, art in Ancient Rome took on a wider, and sometimes more utilitarian, purpose.

Owing in a large part to the efforts of the Yiddish movement, Yiddish, before the Nazi era, was becoming one of the great languages of the world, spoken by over 11, 000, 000 people.

Owing to the distance and difficulty in traveling from the valley of Ribeira da Cruz, in 1757, the parish vicar ( Father Agostinho Pereira de Lacerda ) requested that the bishop of Angra ( at that time Brother Valério do Sacramento ) anex Caveira to the neighboring parish of São Caetano da Lomba ( even though it was part of the neighboring municipality ).

Owing to the rain shadow created by the Otway Ranges to the southwest, the You Yangs are in the driest part of Victoria south of the Great Dividing Range.

Owing to its proximity to Durham City, the area was allocated a Durham postcode, DH4, which forms part of the Houghton-le-Spring post town.

Owing to Spanish involvement, and the strategic advantages to be gained, the battle also formed part of the Anglo-Spanish War ( 1585-1604 ), the wider conflict of Protestant England against Catholic Spain.

Owing in part to its relatively recent construction, Trinidad bore the weathering of time fairly well, and modern historical societies have maintained the current, well-preserved state of the ruins to this day.

Owing to the increasingly poor condition of Windsor Park, various proposals for its replacement were mooted, including the idea of a multi-purpose stadium hosting football, rugby union and Gaelic games on the site of the former Maze prison, or a national stadium built as part of a major leisure development at Sydenham in east Belfast.

Owing to reservations on the part of Buddah, however, the album was not released.

Owing to the ageing of buildings, the reconstruction of Lam Tin Estate was announced in September 1995 as part of an urban renewal project.

Owing to a certain want of care, there is not a single part in Ksemendra's " List of Kings " ( Nrpavali ) free from mistakes, though it is the work of a poet.

Owing to the large trenches dug to accommodate these tracks for trains and light-rail, the only way to access this part of Schöneberg is by crossing one of the many bridges that span the tracks, thus forming the area into an " island.

Owing to this local dealing, the city dwellers find that their grain yields are the best, and for the first time make deliberate and conscious selection.

Owing to the many confrontations that took place, one of their main tasks was to provide medical assistance, and even today the eight-pointed cross is still in wide use in ambulances and first aid organisations.

Owing to Wagner's relationship with the then unknown philosopher Friedrich Nietzsche, the first Bayreuth festival is cited as a key turning point in Nietzsche's philosophical development.

Owing to the success of his monetary policy, he became well known in other European countries, and this led to his appointment in 1998 as the first president of the new European Central Bank in Frankfurt, much to the chagrin of France, who wanted a French candidate.

Owing to the multiple bisection of the State by navigable waterways, travel overland thru central Virginia was haphazard at best until after the first quarter of the 19th Century.

Owing to the impending birth of their first child, both Lucy and Desi insisted on staying in Hollywood and producing the show on film, something a few Hollywood-based series had begun doing.

Owing to inexperience as well as other circumstances, her first appearances as Portia and in other parts were not well received and she received a note from the manager of Drury Lane stating that her services would not be required.

Owing to the prominence of his father and the alliance between the anti-Home Rule Liberal Unionists and Conservatives, Chamberlain was returned unopposed on 30 March, and at the first sitting of the new session he walked up the floor of the house flanked by his father and his uncle Richard.

* 1912: Owing to strong passenger demand, the first double-deck tramcar was introduced in 1912.

Owing to government pressure from the Palmer Raids of the first red scare, the entire communist movement in America had operated a clandestine model of organization, akin to that of the Russian Social Democratic Workers Party prior to the Russian Revolution.

Owing to the limited metallurgy of the period, Hackworth's first spring valves used an accordion-like stack of multiple leaf springs.

Owing to its small population, it is not surprising that Johnians tend to know one another regardless of year, course, or accommodation ( all first years and the majority of finalists live in college, with the second years required to find their own accommodation ), and this bond contributes to College life immensely.

Owing to the two stages of composition, Schubert's order in the song-cycle preserves the integrity of the cycle of the first twelve poems published and appends the twelve new poems as a Fortsetzung ( Continuation ), following Müller's order ( if one excludes the poems already set ) with the one exception of switching " Die Nebensonnen " and " Mut !".

Owing to the consent given by this king he is counted as the first founder of this monastery.

Owing to his reduced appearances, Hutton failed to reach 1, 000 first-class runs for the first time since 1936, reaching 912 runs at an average of 35. 07.

Owing to the help of the Black Sea Fleet under Aleksey Greig, Varna was the first to be taken ( September 29 ).

Owing to the terrorist attacks on London on the 7th and 21 July 2005, the first episode of the second series ( in which a member of the bin Laden family attempted to buy British Airways ) was replaced by an episode from later in the series.

Owing to the inter-urban nature of operations tram cars will stop within reason at any point where it is safe to do so, the notable exceptions being where the line runs parallel to a main road ; the majority of the first section of the line as far as Baldrine Station runs in this way, as do sections on the approach to the northern terminus as the line runs into the suburban area of Ramsey.

Owing to the club's lower league position, they failed to qualify for the competition for the first time in three years.

Owing to high production costs, only the first two episodes of the first series were filmed on location in Singapore.

Owing to Zinzendorf's personal contacts with their royalty, the first Moravian missions were directed to the Dano-Norwegian Empire.

Owing to the Ducatus Romanus (" Duchy of Rome ") of the popes, which cut it off from the rest of Lombard Italy, Benevento was from the first practically independent.

Owing to the further absence of O ' Driscoll from the Irish squad for the first match of the Six Nations in that season against France, D ' Arcy found himself in the number 13 jersey at international level.