A theoretical synthesis in 2000 suggested the following mechanism: thalidomide intercalates ( inserts itself ) into DNA in guanine-cytosine-rich regions .< ref > Owing to its glutarimide part, ( S ) thalidomide fits neatly into the major groove of DNA at purine sites.

Owing in part to the first VH1 broadcasts of Nick Read's documentary Warren Zevon: Keep Me In Your Heart, the album reached number 16 on the US charts, Zevon's highest placement since Excitable Boy.

Owing in part to the different countries in which the lyricist and composers resided, recording on the album musical of Chess began in Stockholm in early November 1983, with Andersson recording the many layered keyboard parts himself along with other basic work at their usual Polar Studios.

Owing to his father's work around the globe Pierre was part of the original jetset, and claims that constant travel took its toll on his academic life, though he was always able to draw and paint, and was published as a cartoonist while still in his early teens.

Owing in large part to the results of research and activism by this group, the Official Languages Act was passed in 1969.

# Owing, in part, to abuses of this system ( especially for patronage ), there was enormous resentment of the Church, taking the various forms of atheism, anticlericalism, and anti-Catholicism.

Owing in part to the influence of his mentor, Sir Robert Woods, Gogarty had decided to specialize in otolaryngology, and in Vienna he studied under Ottokar Chiari, Markus Hajek, and Robert Bárány.

Owing to the widespread use of the Textus Receptus ( TR ) as the principal source-language text for Bible editions, the comma is also contained in most translations published from 1522 until the latter part of the nineteenth century.

Owing in part to their vast size, abyssal plains are currently believed to be a major reservoir of biodiversity.

Owing to the continuation of a Gaelic way of life in the north of the county, Oldcastle suffered far more than the richer more arable land in the southern part of County Meath.

Owing in part to the fact that the Roman cities were far larger than the Greek city-states in power and population, and generally less provincial, art in Ancient Rome took on a wider, and sometimes more utilitarian, purpose.

Owing in a large part to the efforts of the Yiddish movement, Yiddish, before the Nazi era, was becoming one of the great languages of the world, spoken by over 11, 000, 000 people.

Owing to the distance and difficulty in traveling from the valley of Ribeira da Cruz, in 1757, the parish vicar ( Father Agostinho Pereira de Lacerda ) requested that the bishop of Angra ( at that time Brother Valério do Sacramento ) anex Caveira to the neighboring parish of São Caetano da Lomba ( even though it was part of the neighboring municipality ).

Owing to the rain shadow created by the Otway Ranges to the southwest, the You Yangs are in the driest part of Victoria south of the Great Dividing Range.

Owing to its proximity to Durham City, the area was allocated a Durham postcode, DH4, which forms part of the Houghton-le-Spring post town.

Owing to Spanish involvement, and the strategic advantages to be gained, the battle also formed part of the Anglo-Spanish War ( 1585-1604 ), the wider conflict of Protestant England against Catholic Spain.

Owing in part to its relatively recent construction, Trinidad bore the weathering of time fairly well, and modern historical societies have maintained the current, well-preserved state of the ruins to this day.

Owing to the increasingly poor condition of Windsor Park, various proposals for its replacement were mooted, including the idea of a multi-purpose stadium hosting football, rugby union and Gaelic games on the site of the former Maze prison, or a national stadium built as part of a major leisure development at Sydenham in east Belfast.

Owing to reservations on the part of Buddah, however, the album was not released.

Owing to the ageing of buildings, the reconstruction of Lam Tin Estate was announced in September 1995 as part of an urban renewal project.

Owing to a certain want of care, there is not a single part in Ksemendra's " List of Kings " ( Nrpavali ) free from mistakes, though it is the work of a poet.

Owing to the large trenches dug to accommodate these tracks for trains and light-rail, the only way to access this part of Schöneberg is by crossing one of the many bridges that span the tracks, thus forming the area into an " island.

Owing to a lack of confidence in the local currency, the US dollar is widely accepted as a medium of exchange alongside the Somali shilling.

Owing to this method, it is impossible for such a device to work in space due to lack of air, but Professor Rode states that there are practical applications for the device on Earth such as, for example, the transportation of microscopic hazardous materials and other microscopic objects.

Owing to lack of funds, Worcester's eighteenth-century building programme proceeded by fits and starts.

Owing to a lack of aircraft supplies, Baker was stuck in Paris, and doubted he would ever get to the front.

Owing to the lack of a mainline railway the ore was transferred to a wharf at Gunness ( or Gunhouse ), initially by cart then by a narrow gauge railway, for distribution by barge or mainline rail from Keadby.

Owing to a lack of written material, he was obliged to trust to his memory ; therefore caution has to be exercised in reading his work.

Owing to his lack of established residency rights in Britain and during his earlier exile in Ireland the name Roger or Roger Tennant was used as a pseudonym.

Owing to the lack of labour immigration before 1989, there are only very few Muslims in the former East Germany.

Owing to a lack of ticket barriers, and the difficulty of ticket verification when trains are crowded, the line has historically had a high level of fare avoidance.

Owing to its lack of military dress and boots, the Germans provided for Kaminskis brigade enough used uniforms to outfit four battalions.

Owing to the lack of mineralization in many of the forest specimens, the traditional characterization of " fossilisation " fails for these forests and " mummification " may be a clearer description.

Owing to their cheap production, their perceived lack of value, and such hazards as war-time paper drives, the penny dreadfuls, particularly the earliest ones, are fairly rare today.

Owing of this overall lack of meaningful evidence, Ives Goddard and Lyle Campbell claim that any connections between Beothuk and Algonquian are unknown and likely unknowable.

Owing to Kwan's lack of acting experience, at Stark's request, she traveled to the United States, where she attended acting school in Hollywood and resided in the Hollywood Studio Club, a chaperoned dormitory, with other junior actresses.

Owing to unemployment, increasing rural-urban migration, attraction of city life and a lack of political will, India now has one of the largest number of child laborers in the world.

Owing to the worldwide recession and a lack of long term investment, production was halted at LDV's Birmingham factory in December 2008.

Owing to the lack of dues of the national group in this period, such a relationship was more theoretical than practical.

Owing to lack of funds, the wing intended as accommodation for the headmaster and boarders was never built.

Owing to his increasing weight and lack of physical fitness, he found batting much harder.

Owing to a lack of adequate medical facilities in Santa Marta, Bastidas attempted to sail to Santo Domingo, but bad weather forced him to land in Cuba, where he died from his injuries.

Owing to the areas poor fertility and lack of shelter from the sea, the settlers moved farther into the interior.

Owing partially to the excellent form of his teammate Diego Milito and partially due to a lack of consistency in managerial preferences and squad selection, Pazzini made a majority of his appearances for Inter during the 2011-2012 season as a substitute coming off the bench.

Owing to the lack of rain, Ko Samet still ships in potable water to the island.

Owing to lack of research, much is not known about octopamine or its role in humans.