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Protein-bound paclitaxel ( e. g., Abraxane ) or nab-paclitaxel was approved by the U. S. Food and Drug Administration ( FDA ) in January 2005 for the treatment of refractory breast cancer.
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Protein-bound and paclitaxel
# REDIRECT Protein-bound paclitaxel
paclitaxel and .
This is the TAXUS Express < sup > 2 </ sup > Paclitaxel-Eluting Coronary Stent System, which releases paclitaxel.
Docetaxel is a semi-synthetic analogue of paclitaxel.
Nanoparticles have emerged as a useful vehicle for poorly soluble agents such as paclitaxel.
This formulation of paclitaxel uses human albumin as a vehicle and not the Cremophor vehicle used in Taxol.
* For example, the cancer-fighting taxane class of drugs paclitaxel and docetaxel block dynamic instability by stabilizing GDP-bound tubulin in the microtubule.
* Abraxane, approved by Food and Drug Administration to treat breast cancer, is the nanoparticle albumin bound paclitaxel.
The hydrophilic carbonic clusters functionalized with polyethylene glycol or PEG-HCC are mixed with the chemotherapeutic drug paclitaxel ( Taxol ) and the epidermal growth factor receptor ( EGFR ) targeted Cetuximab and injected intravenously.
The standard treatment contains Cremophor EL which allows the hydrophobic paclitaxel to be delivered intravenously.
Replacing the toxic Cremophor with carbon nanoparticles eliminated its side effect and improved drug targeting which in turn required a lower dose of the toxic paclitaxel.
SLCO1B3 has been identified as the human hepatic uptake transporter for amatoxins ; moreover, substrates and inhibitors of that protein — among others rifampicin, penicillin, silibinin, antamanide, paclitaxel, ciclosporin and prednisolone — may be useful for the treatment of human amatoxin poisoning.
The Pacific Yew Taxus brevifolia, native to the Pacific Northwest of North America, and Canada Yew Taxus canadensis are the sources of paclitaxel or Taxol, a chemotherapeutic drug used in breast and lung cancer treatment and, more recently, in the production of the Taxus drug eluting stent by Boston Scientific.
The more common Canada yew, Taxus canadensis, is also being successfully harvested in northern Ontario, Québec and New Brunswick, and has become another major source of paclitaxel.
Docetaxel, an analogue of paclitaxel, is derived from the Taxus baccata.
An important cancer drug, Taxol ( paclitaxel ), is a phytochemical initially extracted and purified from the Pacific yew tree.
Current paclitaxel production comes from renewable sources.
BMS also held the original paclitaxel license, but there are now multiple generic producers.
Sirolimus, paclitaxel and everolimus are the three drugs used in coatings which are currently FDA approved in the United States.
Typical chemotherapy agents are a combination of paclitaxel and carboplatin.
Clinically useful drugs which have been recently isolated from plants include the anticancer agent paclitaxel ( Taxol ) from the yew tree, and the antimalarial agent artemisinin from Artemisia annua.
For example, one yew tree would have to be cut down to extract enough paclitaxel from its bark for a single dose.
Another recent example is that of paclitaxel.
paclitaxel and was
As it was already becoming scarce when its chemotherapeutic potential was realized, the Pacific yew was never commercially harvested from its habitat at a large scale ; the widespread use of the paclitaxel ( taxol ) was enabled when a semi-synthetic pathway was developed from extracts of cultivated yews of other species.
paclitaxel and approved
In 2006, the FDA approved bevacizumab for use in first-line advanced nonsquamous non-small cell lung cancer in combination with carboplatin / paclitaxel chemotherapy.
On March 28, 2007, the European Commission approved bevacizumab in combination with paclitaxel for the first-line treatment of metastatic breast cancer.
paclitaxel and by
As paclitaxel is metabolized primarily by CYP2C8, its bioavailability may be increased unpredictably, potentially leading to harmful side-effects.
It potentially does this by destroying only the cancer cells susceptible to the drug ( targeting those that are CD44-positive, a trait which has been associated with increased survival time in some ovarian cancers ), and allowing the cells which are unaffected by paclitaxel ( CD44-negative ) to regrow, even after a reduction in over a third of the total tumor size.
paclitaxel and Drug
AHFS Drug Information ( 2010 ) identifies quercetin as an inhibitor of CYP2C8, and specifically names it as a drug with potential to have harmful interactions with taxol / paclitaxel.
paclitaxel and for
" These included Yew trees ( the bark is used for cancer drugs, paclitaxel ).
These included Yew trees ( the bark is used for the cancer drug paclitaxel ); Hoodia ( from Namibia, a potential source of weight loss drugs ); half of Magnolias ( used as Chinese medicine for 5, 000 years to fight cancer, dementia and heart disease ); and Autumn crocus ( for gout ).
At one time, BMS held the solitary contract to harvest the bark of endangered yew trees on United States territory for the manufacture of chemotherapy drug paclitaxel ( Taxol ).
Chemotherapy with drugs such as liposomal anthracyclines or paclitaxel may be used, particularly for invasive disease.
paclitaxel and treatment
Bevacizumab did not meet its primary endpoint of extending overall survival ( OS ) in a recent phase III trial in unresectable gastric cancer ( in combination with paclitaxel / Taxol ), but it did demonstrate a positive result in treatment of ovarian cancer.
It is a first-in-class, innovative treatment regimen designed to address unmet needs associated with solvent-based paclitaxel such as hypersensitivity reactions, increased myelosuppression and axonal degeneration.
The chemotherapy drug paclitaxel ( taxol ), used in breast, ovarian, and lung cancer treatment, is derived from Taxus brevifolia.
paclitaxel and cancer
The chemical structure of paclitaxel or TAXOL, a mitotic inhibitor used in cancer chemotherapy
Some treatments with chemotherapy, such as paclitaxel in ovarian cancer ( a cancer usually discovered in late stages ), may actually induce chemoresistance ( 55-75 % relapse < 2 years ).
While paclitaxel alone, as of late, does not cure the cancer, it is effective at extending the survival time of the patients.
e and .
It will be noted that point f has seven nearest neighbors, h and e have six, and p has only one, while the remaining points have intermediate numbers.
In any social system in which communications have an importance comparable with that of production and other human factors, a point like f in Figure 2 would ( other things being equal ) be the dwelling place for the community leader, while e and h would house the next most important citizens.
A man named Blaine Smythe, with `` y '' and `` e '' but pronounced without them, had been fired at Payne's insistence.
The family moved north across the Ohio River to free ( i. e., non-slave ) territory and made a new start in what was then Perry County but is now Spencer County, Indiana.
Altruism is a motivation to provide something of value to a party who must be anyone but oneself, while duty focuses on a moral obligation towards a specific individual ( e. g., a god, a king ), or collective ( e. g., a government ).
Pure altruism consists of sacrificing something for someone other than the self ( e. g. sacrificing time, energy or possessions ) with no expectation of any compensation or benefits, either direct, or indirect ( e. g., receiving recognition for the act of giving ).
This religion preaches the view of Ahimsa – to live and let live, thereby not harming sentient beings, i. e. uncompromising reverence for all life.
A constant concern for Allah ( i. e. God ) results in a careful attitude towards people, animals, and other things in this world.
This concept was emphasized by Sufi mystics like Rabia al-Adawiyya who paid attention to the difference between dedication to Allah ( i. e. God ) and dedication to people.
The so-called " Four Field Approach " has its origins in Boasian Anthropology, dividing the discipline in the four crucial and interrelated fields of sociocultural, biological, linguistic, and archaic anthropology ( e. g. archaeology ).
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