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Sertraline was approved by the U. S. Food and Drug Administration ( FDA ) in 1991 based on the recommendation of the Psychopharmacological Drugs Advisory Committee ; it had already become available in the United Kingdom the previous year.
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Sertraline and was
Sertraline was equivalent to imipramine for the treatment of depression with co-morbid panic disorder, but it was better tolerated.
Sertraline treatment of depressed patients with co-morbid personality disorders improved their personality traits, and this improvement was almost independent from the improvement of their depression.
Sertraline was equivalent to imipramine for both of these indications during the first 12 weeks of the study and the 16-week continuation phase.
Sertraline used for the treatment of depression in elderly ( older than 60 ) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline ( Pamelor ) and imipramine.
Sertraline was also marginally more efficacious than fluoxetine ( Prozac ).
The authors of the study argued that the improvement achieved with sertraline is different and of a better quality than the improvement achieved with placebo .< ref name =" pmid10945134 "> Review: Sertraline was equally effective for men and women and for patients with or without agoraphobia.
Sertraline was not effective for veterans with combat-related PTSD.
Sertraline is often used in combination with stimulant medication for the treatment of co-morbid depression and / or anxiety in ADHD Studies have shown there was an increase in the concentration of amphetamine in the brain in rats pretreated with 5 mg / kg sertraline.
Sertraline had a slight inhibitory effect on the metabolism of diazepam, tolbutamide and warfarin, which are CYP2C9 or CYP2C19 substrates ; this effect was not considered to be clinically relevant.
Sertraline is less popular in the UK ( 2003 data ) and Canada ( 2006 data )— in both countries it was fifth ( among drugs marketed for the treatment of MDD, or antidepressants ), based on the number of prescriptions.
Sertraline and by
Sertraline has been shown to augment the locomotor stimulatory effect of amphetamine by decreasing the metabolism of amphetamine, perhaps via actions on cytochrome P450 isozymes.
Sertraline can be deaminated in vitro by monoamine oxidases ; however, this metabolic pathway has never been studied in vivo.
Sertraline and U
* U. S. National Library of Medicine: Drug Information Portal – Sertraline
Sertraline and .
** Selective Serotonin Reuptake Inhibitors ( SSRIs ): Citalopram, Dapoxetine, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline.
Sertraline hydrochloride ( trade names Zoloft and Lustral, among others ) is an antidepressant of the selective serotonin reuptake inhibitor ( SSRI ) class.
Sertraline is primarily used to treat major depression in adult outpatients as well as obsessive – compulsive, panic, and social anxiety disorders in both adults and children.
Sertraline also alleviates the symptoms of premenstrual dysphoric disorder and can be used in sub-therapeutic doses or intermittently for its treatment.
Sertraline shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects ; however, it has relatively mild effects on both cognition and vigilance.
Sertraline is effective for both severe depression and dysthymia, a milder and more chronic variety of depression.
Sertraline also improved the depression of dysthymic patients to a greater degree than group cognitive behavioral therapy or interpersonal psychotherapy, and adding psychotherapy to sertraline did not seem to enhance the outcome.
Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline.
Sertraline appears to be associated with microscopic colitis, a rare condition of unknown etiology.
Sertraline is a moderate inhibitor of CYP2D6 and CYP2B6 in vitro.
Sertraline had no effect on the actions of digoxin and atenolol, which are not metabolized in the liver.
Sertraline is primarily a serotonin reuptake inhibitor ( SRI ), with a binding affinity ( K < sub > i </ sub >) of 3. 3 nM.
Sertraline molecule Sertraline is also a dopamine reuptake inhibitor, with a K < sub > i </ sub >= 315 nM, a σ < sub > 1 </ sub > receptor agonist with 5 % of its SRI potency, and an α < sub > 1 </ sub >- adrenoreceptor antagonist with 1 – 10 % of its SRI potency.
Sertraline demonstrated anti-fungal activity against Candida species in vivo.
was and approved
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