Significant alcohol intake produces changes in the brain's structure and chemistry, though some alterations occur with minimal use of alcohol over a short term period, such as tolerance and physical dependence.

Significant changes came in 1910 with the reform of the Roman Breviary by Pope Pius X.

Significant syntactic changes have arisen in Modern Hebrew as a result of non-Semitic substrate influences.

" Significant changes happened in the British Poor Law system in England and Wales, Scotland, and Ireland.

Significant changes occurred in the economy of the Tennessee Valley and the nation, prompted by an international oil embargo in 1973 and accelerating fuel costs later in the decade.

Significant crops in montane forest zones include tea and coffee, and the logging of unique species causes changes to the forest structure.

Significant changes in the number of fixed and mobile services deployed in Bangladesh occurred in the late 1990s and the number of services in operation have subsequently grown exponentially in the past five years.

Significant changes to the cathedral were made by the architect James Wyatt in 1790, including replacement of the original rood screen and demolition of the bell tower which stood about 320 feet ( 100 m ) north west of the main building.

Significant changes in its management and language were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes were made to the program as Ross asserted her influence.

Significant organisational changes to the base occurred as a result of the post-Cold War reorganization of the USAF.

Significant changes have occurred since the largest private shareholder, Alcatel, sold its stake in Thales to Dassault.

Significant changes are the improvement of the rear sight form transitioning from a V-notch type like those on a Type 38, to an aperture, the front sight blade was renewed to a triangular shape, chrome-lined barrels were used, and on earlier productions, the rear sight was equipped with anti-aircraft calipers.

Significant changes introduced into the 1968 document included Article 6, which committed the state to adhere to the " principles of socialist internationalism " and to devote special attention to its " fraternal ties " with the Soviet Union ; Article 9, which based the national economy on the " socialist ownership of the means of production "; Article 20, which under pressure from the churches granted freedom of conscience and belief ; Article 21, which maintained that the " basic rights " of citizenship were inseparably linked with " corresponding obligations "; and Article 47, which declared that the principle of " democratic centralism " is the authoritative maxim for the construction of the socialist state.

Significant changes in the language and management of the province were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes in pressure during the procedure can indicate tumors or spinal blockage resulting in a large pool of CSF, or hydrocephalus associated with large volumes of CSF.

Significant changes for the album Ageless Decay are the artwork by Dimitar Nikolov and the mixing and mastering by Tommy Hansen.

Significant changes were made to Dr. Loveless ( played by Kenneth Branagh in the film ).

Significant powertrain changes were made for 1986.

Significant hypercalcaemia can cause ECG changes mimicking an acute myocardial infarction.

Significant changes enacted at the national levels included the imposition of an income tax with the Sixteenth Amendment, direct election of Senators with the Seventeenth Amendment, Prohibition with the Eighteenth Amendment, and women's suffrage through the Nineteenth Amendment to the U. S. Constitution.

Significant changes under autonomy are the setting up of Distance Education Programmes ( DEP ) with IIT Bombay, with VJTI being a Remote Centre ; as also the modernization of the Library to a digital library.

Significant changes to the game's ending were made late in development following the September 11 attacks in New York, where the finale occurs.

Significant changes in cays and their surrounding ecosystems can result from natural phenomena such as severe El Niño Southern Oscillation ( ENSO ) cycles.

Significant changes in the Leaving Certificate maths curriculum were reflected in two new textbooks produced by the Irish Christian Brothers.

Significant privatizations of this nature occurred from 1760 to 1820, coincident with the industrial revolution in that country.

Significant rebellions occurred on Tanna and Espiritu Santo and paperwork revealed the direct culpability of France in its desire to see Espiritu Santo become a separate French colony.

Significant amounts of teaching occurred in the museum as well with students claiming they learnt far more in the museum than they ever did in the lecture theatre.

Significant events of the latter variety occurred in Colorado and Kansas in May 2004 with winds to 100 mph ( 161 km / h ), Minnesota and Wisconsin in June 2004 causing significant damage, and the upper Middle West in May 1988, notable for strong electrification and lightning activity and by one estimate reaching 30, 000 ft ( 9, 144 m ) or more.

Significant damaging bushfires occurred in the western and northern sections of the park in the 1990s and early 2000s.

Significant Romanization occurred when the town was selected as the garrison of the Legio XV Apollinaris.

Significant development occurred after the coming of the Chesapeake and Ohio Railroad and George D. Winn's ferry to Portsmouth, Ohio in the 1890s.

Significant growth in recent years has occurred to the northeast, where homes have been built along the ravine of Maple Creek as well as alongside Brooktree Golf Course, to the north, and to the southeast.

Significant beach erosion has occurred at the western end of Emerald Isle.

Significant urban growth occurred in the 1920s, and during the 1930s to 1950s large-scale growth occurred.

Significant growth has occurred in the 1990s in Parowan ; it has been attributed to affordable utility fees and a positive economic climate.

Significant flooding occurred in 1907, 1912, 1917, and 1935.

Significant canyon-shaping events occurred as recently as 15, 000 years ago during a massive outburst flood from Glacial Lake Bonneville in Utah.

Significant opposition to the Iraq War occurred worldwide, both before and during the initial 2003 invasion of Iraq by the United States, United Kingdom, and smaller contingents from other nations, and throughout the subsequent occupation.

Significant school construction in recent years has occurred in response to changing demographics.

Significant erosion occurred on the populated shores of the harbour, particularly in the Bedford Basin where residential properties and railway tracks received most of the wave action.

Significant storm damage occurred as far south as Grenada, where high surf isolated towns from the capital city.

Significant periods of expansion of the university, since the 1972 merger, occurred in the mid-1980s, as well as in 1998, when Joan B. Kroc, philanthropist and wife of McDonald's financier Ray Kroc, endowed USD with a gift of $ 25 million for the construction of the Institute for Peace & Justice.

Significant residential development occurred during the 1960s and 1970s, spurred by industrial growth and public housing construction.