Since Krukenberg tumors are secondary ( metastatic ), management might logically be driven by identifying and treating the primary cancer.

Since higher grade tumors are more likely to undergo metastasis ( invasion and spread to locoregional and distant sites ), they are treated more aggressively.

Since, by definition, benign bone tumors do not metastasize, all secondary bone tumors are metastatic lesions which have spread from other organs, most commonly carcinomas of the breast, lung, and prostate.

Since the gold nanoparticles are taken up by the tumors more than the nearby healthy tissue, the dose is selectively enhanced.

Since mucinous tumors arising from the ovary usually only involve one ovary, the presence of involvement in both ovaries with a mucinous tumor suggests that the tumor may have arisen in another location, and further study is warranted.

Since the adjacent structure is the pituitary gland, some common tumors causing compression are pituitary adenomas and craniopharyngiomas.

Since the center ’ s inception, faculty members have played a key role in the development of both Marquis, the first FDA-approved treatment for equine protozoal myelitis, and GastroGard, a treatment for gastric ulcers, as well as advances in laser surgery joint disease, and treatments for lameness, colic, tumors, tendon and ligament injury, and antibiotic therapy.

Since SNPs are a " quick and dirty " approach to detect genetic indicators of pathologies and lineages, arrays theoretically provide a facile method for diagnosis ; this was confirmed experimentally in the late 1990s in the successful SNP analysis of human tumors.

Since most tumors are supplied by the hepatic artery, arterial embolization interrupts their blood supply and postpones growth until replaced by neovascularity.

Since tumors overexpressing TSP-1 typically grow slower, exhibit less angiogenesis, and have fewer metastases, TSP1 is an attractive target for cancer treatment.

Since its launch, the program has continued to grow and refine its procedures to better accommodate a growing campus ' needs.

Since the amplitude at these reflections grows linearly with the number N of scatterers, the observed intensity of these spots should grow quadratically, like N < sup > 2 </ sup >.

Since then, Namesys has also provided tools to resize ( both grow and shrink ) ReiserFS file systems offline.

Since 2003, high-end bourbons have seen revenue grow from $ 450 million to over $ 500 million, some 2. 2 million cases, in the United States.

Since this cannot stretch, the animals have to molt in order to grow, in other words they grow new but still soft cuticles and then cast off the old one and wait for the new one to harden.

Since 1995 production has increased sharply and was expected to grow by 33 % in 2001 due to the expansion ( costing US $ 860m ) of the Mozal aluminium smelter which was approved in mid-2001.

Since many a country with a transitional political and economic system continues treating its constitution as an abstract legal document disengaged from the economic policy of the state, practice of judicial review of economic acts of executive and legislative branches began to grow.

Since they lived underground, Dwarves did not grow their own food supplies if they could help it, and usually obtained food through trade with Elves and Men.

Since elm wood had few uses before the 20th century, many elms were left standing, and continued to grow, as forestland in its range was cleared for farming or settlement.

Since such a ship might take thousands of years to reach even nearby stars, the original occupants of a generation ship would grow old and die, leaving their descendants to continue travelling.

Since the mid-1990s, Goodhue, like many Midwestern municipalities with medium to large elevator operations, has seen its housing base and population grow.

Since 1950, the city began to grow rapidly.

Since its establishment in 1928, Copiah-Lincoln has continued to grow in size and prestige and now occupies a prominent position in the state's educational system with an enrollment of over 2, 000 and a physical plant valued at more than $ 35 million.

Since World War II, Elizabeth has seen its transportation facilities grow ; the Port Newark-Elizabeth Marine Terminal is one of the busiest ports in the world, as is Newark Liberty International Airport, parts of which are actually in Elizabeth.

Since that point, the town continued to slowly grow into a prosperous community.

Since Red Beard required Mifune to grow a natural beard — one he had to keep for the entirety of the film's two years of shooting — he was unable to act in any other films during the production.

Since 2006, the clinic has continued to grow.

Since then the Speedway has continued to grow.

Since they nest in cold regions, Tundra Swan cygnets grow faster than those of swans breeding in warmer climates ; those of the Whistling Swan take about 60 – 75 days to fledge – twice as fast as those of the Mute Swan for example – while those of Bewick's Swan, about which little breeding data is known, may fledge a record 40 – 45 days after hatching already.

Since the 1990s, although the majority of Malian popular singers are still jelimusow, wassoulou's popularity has continued to grow.

Since their early deaths, and then the death of their father in 1861, they were subject to a following that did not cease to grow.

They also claim that despite having the incarceration rate grow “ 10 times what it was prior to 1970 ”, “ it has not made this country any safer .” Since the September 11 attacks in 2001, the budget for Customs and Border Patrol ( CBP ), and U. S. Immigration and Customs Enforcement ( ICE ), have nearly doubled from 2003 to 2008, with CBP ’ s budget increasing from $ 5. 8 billion to $ 10. 1 billion and ICE from $ 3. 2 billion to $ 5 billion and even so there has been no significant decrease in immigrant population.

Since 1944 he has also conducted regularly at the San Francisco Opera, where he made his debut with a memorable performance of Verdi's Falstaff.

Since the slogans have little application to reality and are sanctimonious to boot, the applause is faint even in areas of the world where we should expect to find the greatest affection for free government.

Since his parents are now renting his room to a lodger, Alex wanders the streets and enters a public library where he hopes to learn a painless way to commit suicide.

Since the early 20th century it has been commonly accepted that Old Irish Bel ( l ) taine is derived from a Common Celtic * belo-te ( p ) niâ, meaning " bright fire " ( where the element * belo-might be cognate with the English word bale in ' bale-fire ' meaning ' white ' or ' shining '; compare Anglo-Saxon bael, and Lithuanian / Latvian baltas / balts, found in the name of the Baltic ; in Slavic languages byelo or beloye also means ' white ', as in Беларусь ( White Russia or Belarus ) or Бе ́ лое мо ́ ре Sea ).

Since Rimbert mentions them to have crossed the seas by ship " where it was possible " they clearly had the alternative of going around them as well, meaning that the seas were probably the numerous lakes in southern Sweden.

Since the second half of the 20th century, computers have been programmed to play chess with increasing success, to the point where home computers can play chess at a very high level.

Since 2002, Charles has been a DJ on BBC Radio 6 Music, presenting The Craig Charles Funk and Soul Show, where he plays a diverse range of funk and soul music, from classic tracks to the latest releases, and provides publicity for new bands.

Since the discovery of his " Letter to the Alexandrians " in the last century, much work has been done to rehabilitate Claudius and determine where the truth lies.

Since then, carriage on digital cable, satellite and digital terrestrial has introduced Channel 4 to Welsh homes where it is now universally available.

Since 2005, the Bengals wear white for September home games where the heat could become a factor.

Since the 1980s, following the popularization of computer technology, it has become fashionable in marketing for names of products and companies, and for 1990s online video games where players use pseudonyms ( when spaces were not allowed ).

Since we are assuming circular motion, let r ( t ) = R · u < sub > r </ sub >, where R is a constant ( the radius of the circle ) and u < sub > r </ sub > is the unit vector pointing from the origin to the point mass.

where and as Since and, the above can be re-written as

Since Cartesian coordinates are unique and non-ambiguous, the points of a Cartesian plane can be identified with all possible pairs of real numbers ; that is with the Cartesian product, where is the set of all reals.

Since there are no punctuation marks in Classical Chinese, it can be difficult to conclusively determine where one sentence ends and the next begins.

Since the onset of the migration from TDM PBXs to VoIP and VoIP hybrid solutions, manufacturers such as Lantiq, Ascom Wireless Solutions, Aastra Technologies, Philips, snom and Polycom have developed IP-DECT solutions where the backhaul from the base station is VoIP ( H. 323 or SIP ) while the handset loop is still DECT.

Since the proving of the theorem, efficient algorithms have been found for 4-coloring maps requiring only O ( n < sup > 2 </ sup >) time, where n is the number of vertices.

Since in the mid-1990s the number of supporters started to decrease, Greenpeace pioneered the use of face-to-face fundraising where fundraisers actively seek new supporters at public places, subscribing them for a monthly direct debit donation.

Since Majorana masses of the right-handed neutrino are forbidden by SO ( 10 ) symmetry, SO ( 10 ) GUTs predict the Majorana masses of right-handed neutrinos to be close to the GUT scale where the symmetry is spontaneously broken in those models.

Since the World War II, copper and plastic piping has replaced galvanized piping for interior drinking water service, but galvanized steel pipes are still used in outdoor applications where mechanical strength is required.

Since the 18th century the writ has also been used in cases of unlawful detention by private individuals, most famously in Somersett's Case ( 1772 ), where the black slave Somersett was ordered to be freed.

Since most wiki systems use URLs for individual pages where the page's title appears at the end of an otherwise unchanging address, the simplest way of defining such mappings is by substituting the interwiki prefix for the unchanging part of the URL.

Since air is an insulator, in principle no other substance is needed to keep power where it should be.

Since 1927 South Australia has permitted majority verdicts of 11: 1, and 10: 1 or 9: 1 where the jury has been reduced, in criminal trials if a unanimous verdict cannot be reached in four hours.

Since a compiler seldom knows where an object will reside, it often assumes a fixed base location ( for example, zero ).