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The PKG-I and PKG-II are homodimers of two identical subunits (~ 75 kDa and ~ 85 kDa, respectively ) and share common structural features.
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PKG-I and PKG-II
Two PKG genes, coding for PKG type I ( PKG-I ) and type II ( PKG-II ), have been identified in mammals.
Whereas PKG-I is predominantly localized in the cytoplasm, PKG-II is anchored to the plasma membrane by N-terminal myristoylation.
In general, PKG-I and PKG-II are expressed in different cell types.
PKG-I and two
The N-terminus of PKG-I is encoded by two alternatively spliced exons that specify for the PKG-Iα and PKG-Iβ isoforms.
PKG-I and .
* PKG-I has been detected at high concentrations ( above 0. 1 µmol / L ) in all types of smooth muscle cells ( SMCs ) including vascular SMCs and in platelets.
PKG-II and .
* PKG-II has been detected in renal cells, zona glomerulosa cells of the adrenal cortex, Clara cells in distal airways, intestinal mucosa, pancreatic ducts, parotid and submandibular glands, chondrocytes, and several brain cell nuclei, but not in cardiac and vascular myocytes.
are and homodimers
The proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators such as cytochrome c and SMAC.
Receptor binding as well as membrane fusion are catalyzed by the protein E, which changes its conformation at low pH, which causes a rearrangement of the 90 homodimers to 60 homotrimers.
* Ly49 ( homodimers ) — a relatively ancient, C-type lectin family receptor ; are of multigenic presence in mice, while humans have only one pseudogenic Ly49 ; the receptor for classical ( polymorphic ) MHC I molecules.
** receptor tyrosine kinase – Functional receptors are homodimers.
Both classes are flavoproteins which function as homodimers.
Type III filaments such as GFAP are capable of forming both homodimers and heterodimers ; GFAP can polymerize with other type III proteins or with neurofilament protein ( NF-L ).
Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα ( αα ) or ERβ ( ββ ) homodimers or ERαβ ( αβ ) heterodimers.
RPB3, RPB5, and RPB7 interact with themselves to form homodimers, and RPB3 and RPB5 together are able to contact all of the other RPB subunits, except RPB9.
Less-common homodimers of the CD8-α chain are also expressed on some cells.
These are generally palindromic sequences ( because restriction enzymes usually bind as homodimers ), and a particular restriction enzyme may cut the sequence between two nucleotides within its recognition site, or somewhere nearby.
The cadherins are a family of transmembrane proteins that form homodimers in a calcium-dependent manner with other cadherin molecules on adjacent cells.
STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS ( Interferon-Gamma Activated Sequence ) promoter to induce expression of ISG ( Interferon Stimulated Genes ).
are and two
But in our case -- and neither my wife nor I have extreme views on integration, nor are we given to emotional outbursts -- the situation has ruined one or two valued friendships and come close to wrecking several more.
The two main charges levelled against the Bourbons by liberals is that they are racists and social reactionaries.
( There are two receivers in case one should be dropped and damaged.
It seems that for Persia, and especially for this city, there are only two times: the glorious past and the corrupt, depressing, sterile present.
The one apparent connection between the two is a score of buildings which somehow or other have survived and which naturally enough are called `` historical monuments ''.
These songs ( practically all Persian music, for that matter ) are limited to a range of two octaves.
Here are the two Preambles: Federal Constitution, 1789
Whatever pole of this contrast one emphasizes and whatever the tension between these two approaches to understanding the artistic imagination, it will be readily seen that they are not mutually exclusive, that they belong together.
But people can't be made to integrate, socialize ( the two are inseparable by Southern standards ) by law.
Of these there are surely few that would be more rewarding discoveries than Verner Von Heidenstam, the Swedish poet and novelist who received the award in 1916 and whose centennial was celebrated two years ago.
In the mystery story, as in The Wealth of Nations, individualism and the social good are two sides of the same benevolent coin.
So all-important are ideas, we are told, that persons successful in business and happy in social life usually fall into two classes: those who invent new ideas of their own, and those who borrow, beg, or steal from others.
These ways are absolutely irreconcilable because they offer two different recipes for man's redemption from chaos.
Within this context of spontaneous and unanalyzed responses to the experience of civilizational crisis, two basic organizations of response are observable: reaction and ideological progressivism.
There is probably some significance in the fact that two of the best incest stories I have encountered in recent years are burlesques of the incest myth.
Here, in two nations alone, are almost five hundred million people, all working, and working hard, to raise their standards, and in doing so, to make of themselves a strong bulwark against the spread of an ideology that would destroy liberty.
`` the matters to be considered are obviously of a grave character, and I therefore respectfully request that the hearing be postponed for two weeks in order that I might make adequate preparation ''.
Office workers frequently go out there to lunch and swim during the siesta period, which, during the summer, lasts from two until five in the afternoon, when shops and offices are again open for business.
But there are at least two reasons for contemplating one's mind in even a cracked mirror.
There are only two men remaining in Congress who, with Rayburn, voted for the declaration of war against Germany in 1917.
Regardless of the decision two facts are clear.
Some brilliant rookies nailed them down, so that this spring just two spots, left and right field, are really up for grabs.
The speed is controlled by pressing on the two brake buttons located where the index finger and thumb are placed when holding the motor.
The biggest nuclear device the United States has exploded measured some 15 megatons, although our B-52s are said to be carrying two 20-megaton bombs apiece.
0.630 seconds.