There are seven mammalian STAT family members which have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 ( STAT5A and STAT5B ), and STAT6.

FANCC was also shown to bind STAT1 and help receptor docking and phosphorylation of STAT135, which helps in tumor suppression.

The proapoptotic homodimers are required to make the mitochondrial membrane permeable for the release of caspase activators such as cytochrome c and SMAC.

Receptor binding as well as membrane fusion are catalyzed by the protein E, which changes its conformation at low pH, which causes a rearrangement of the 90 homodimers to 60 homotrimers.

* Ly49 ( homodimers ) — a relatively ancient, C-type lectin family receptor ; are of multigenic presence in mice, while humans have only one pseudogenic Ly49 ; the receptor for classical ( polymorphic ) MHC I molecules.

** receptor tyrosine kinase – Functional receptors are homodimers.

Both classes are flavoproteins which function as homodimers.

Type III filaments such as GFAP are capable of forming both homodimers and heterodimers ; GFAP can polymerize with other type III proteins or with neurofilament protein ( NF-L ).

Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα ( αα ) or ERβ ( ββ ) homodimers or ERαβ ( αβ ) heterodimers.

RPB3, RPB5, and RPB7 interact with themselves to form homodimers, and RPB3 and RPB5 together are able to contact all of the other RPB subunits, except RPB9.

The PKG-I and PKG-II are homodimers of two identical subunits (~ 75 kDa and ~ 85 kDa, respectively ) and share common structural features.

Less-common homodimers of the CD8-α chain are also expressed on some cells.

These are generally palindromic sequences ( because restriction enzymes usually bind as homodimers ), and a particular restriction enzyme may cut the sequence between two nucleotides within its recognition site, or somewhere nearby.

The cadherins are a family of transmembrane proteins that form homodimers in a calcium-dependent manner with other cadherin molecules on adjacent cells.

In general, they bind to and activate the erbB family of receptor tyrosine kinases ( erbB2 ( HER2 ), erbB3 ( HER3 ), and erbB4 ( HER4 )), functioning both as heterodimers and homodimers.

It is possible that as neuroblasts reach the higher levels they stop their migration either because of the heightened combined expression of all forms of reelin, or due to the peculiar mode of action of the full-sized reelin molecules and its homodimers.

Accidental war is so sensitive a subject that most of the people who could become directly involved in one are told just enough so they can perform their portions of incredibly complex tasks.

We have staved off a war and, since our behavior has involved all these elements, we can only keep adding to our ritual without daring to abandon any part of it, since we have not the slightest notion which parts are effective.

In contrast to all this, primary data are data of a self involved in environing processes and powers.

Our most elemental and unavoidable impressions, he says, are those of being involved in a large arena of powers which have a longer past than our own, which are interrelated in a vast movement through the present toward the future.

Within this frame of reference policies appropriate to claims advanced in the name of the Jews depend upon which Jewish identity is involved, as well as upon the nature of the claim, the characteristics of the claimant, the justifications proposed, and the predispositions of the community decision makers who are called upon to act.

More importantly, several of the more advanced of the less developed countries have found through experience that they must plan their own complex investment programs for at least 5 years forward and tentatively for considerably more than that if they are to be sure that the various interdependent activities involved are all to take place in the proper sequence.

Assuming an adjustment to the July 1 to June 30 fiscal year, the required adjustment of the tax collection years and the towns involved are shown in Table 3.

Other factors playing a part in the extent of AM service and interference are the frequency involved, the time of year, the position of the year in the sunspot cycle, ground conductivity along the transmission path, atmospheric and manmade noise, and others.

By this standard, it is determined that where two stations operating on the same frequency are involved, objectionable interference from station A exists at any point within the service area of station B where station A's signal is of an intensity one-twentieth or more of the strength of station B's signal at that point.

Factors involved in the displacement formula are the bore diameter of the engine's cylinders, the length of the piston stroke, the number of cylinders in the engine, and a constant.

In medicine the frequencies are much higher, transducers and the sonar beams themselves are much smaller, and different scanning techniques may be used, but the principles involved are the same as in sonar.

`` We presently are involved in inaugurating a new development center.

`` You are bound to get involved with people when you have children '', Fran had told me at our first meeting, `` so it is good to know that those with whom you get involved are not just dreary little housewives and dull husbands, but People Who Do Things ''.

This conformational entropy is, in this case, equal to the usual entropy, for there are no other changes or other energies involved.

Huge industries are involved also in the production of biological products, drugs and cosmetics which are liable to this type of attack.

Tension management and communication of sentiment are the processes involved in the functioning of the element of sentiment or feeling.

There are serious dangers involved in this trend toward rising Federal expenditures, of which I take a dim view, but it seems very likely to occur.

The civilizational crisis, the third type of change raises the question `` what are we to do ''??

In the main stream of historical thinking is a group of scholars, H.M. Chadwick, R.H. Hodgkin, Sir Frank Stenton et al. who are in varying degrees sceptical of the native traditions of the conquest but who defend the catastrophic type of invasion suggested by them.

How can we old-fashioned parents, who still feel that adults are due some respect from children, battle the new type of advertising that appears on TV without denying the children the use of television entirely??

Taxation of tangible movable property in Rhode Island has been generally of a `` hands off '' nature due possibly to several reasons: ( 1 ) local assessors, in the main, are not well paid and have inadequate office staffs, ( 2 ) the numerous categories of this component of personal property make locating extremely difficult, and ( 3 ) the inexperience of the majority of assessors in evaluating this type of property.

Important considerations common to each type of shelter are: 1.

They are two good colts of different type.

you must have a list of requirements on where, how many, and what type sites are needed.

How can you cash in on this fast-growing type of outlet and still maintain relationships with older existing outlets which are still important??

Men qualified for the broader task of marketing manager are even more scarce due to the demanding combination of qualifications called for by this type of management work.

New to the field is a duplex type butyrate laminate in which the two sheets of the laminate are of different color.

Signs of this type have already made their appearance in several larger cities, and others are on the way.

The most distal airways are similar to those found in type 1,, being composed of numerous, apparently true terminal bronchioles and occasional, poorly developed respiratory bronchioles ( figs. 14, 15 ).

The pleura is extremely thin in type 2 and septa are absent.

On the other hand, there are a few antithyroid drugs of this same general type, such as resorcinol, possessing no reducing activity and possibly acting through formation of a complex with molecular iodine.

The antithyroid drugs of the thiouracil type, however, are not antagonised by such means.

Moreover, whereas in Interstate Commerce Commission parlance `` variable cost '' means a cost deemed to vary in direct proportion to changes in rate of output, in the type of analysis now under review `` variable cost '' has been used more broadly, so as to cover costs which, while a function of some one variable ( such as output of energy, or number of customers ), are not necessarily a linear function.

For irradiation of food, the results obtained depend upon the dose rather than the specific type of radiation, and X-ray, gamma, and high-energy electron radiation are suitable.

Various of the apartments are of the terrace type, being on the ground floor so that entrance is direct.

Other Saturdays are devoted to studies of a selected American composer, a particular type of music or the music of a given country.

Marinas are less plush than the Florida type but service is good and Creole cooking better.

She said, `` Well, those are the really interesting things, but if you don't like any of those I can turn over some of my extra typing jobs to you, if you think you can type well enough ''.

Ethnoarchaeology is a type of archaeology that studies the practices and material remains of living human groups in order to gain a better understanding of the evidence left behind by past human groups, who are presumed to have lived in similar ways.

The famous Apollo of Mantua and its variants are early forms of the Apollo Citharoedus statue type, in which the god holds the cithara in his left arm.