Captopril is also the only ACE inhibitor which is capable of passing through the blood – brain barrier, although the significance of this characteristic has not been shown to have any positive clinical effects.

The significance of chemotaxis in biology and clinical pathology was widely accepted in the 1930s.

A major change from previous versions was the inclusion of a clinical significance criterion to almost half of all the categories, which required symptoms cause " clinically significant distress or impairment in social, occupational, or other important areas of functioning ".

Subfractions ( HDL-2C, HDL-3C ) can be measured and have clinical significance.

The role of ethanol consumption in acetaminophen overdose is controversial, and a debate that has not yet proven clinical significance.

The veracity and significance of the claims of targeting interfering with clinical priorities are often hard to judge.

This so-called " backwash ileitis " can occur in 10 – 20 % of patients with pancolitis and is believed to be of little clinical significance.

Lymph nodes also have clinical significance.

The clinical significance of the efficacy evidence for TMS in randomized controlled trials was determined by comparison to the published efficacy results for antidepressant pharmacotherapy in similarly designed randomized controlled trials.

Biology has progressed in this field greatly, elucidating complex biochemical mechanisms that appear to underlie diverse aspects of stress, shining a necessary light on its clinical relevance and significance.

The clinical significance of this is that a myocardial infarction involving the PDA is more likely to cause mitral regurgitation.

The significance and clinical importance of these observations and descriptions possibly of ventricular fibrillation were not recognised until John Erichsen in 1842 described ventricular fibrillation following the ligation of a coronary artery ( Erichsen JE 1842 ).

The clinical significance of this finding is that patients with a baseline of compromised lung function will, over a period of time, develop respiratory distress as a meal progresses.

Feline Coronavirus: 2 forms, Feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis ( FIP ), a disease associated with high mortality.

Freud had earlier covered very similar ground in '" A Child is Being Beaten "'-' they both used material from her analysis as clinical illustration in their sometimes complementary papers ' - in which he highlighted a female case where ' an elaborate superstructure of day-dreams, which was of great significance for the life of the person concerned, had grown up over the masochistic beating-phantasy ... which almost rose to the level of a work of art '.

" The quality of the evidence is not strong and the clinical significance unclear ", the reviewers cautioned.

Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

Another clinical significance of the femoral triangle is that the femoral artery is positioned at the midinguinal point ( midpoint between the pubic symphysis and the anterior superior iliac spine ); medial to it lies the femoral vein.

The second and third Korotkoff sounds have no known clinical significance.

Its clinical significance is uncertain.

Hepatitis A infection causes no clinical signs and symptoms in over 90 % of infected children and since the infection confers lifelong immunity, the disease is of no special significance to those infected early in life.

According to some placebo-controlled studies that included a sufficiently high number of participants to determine statistical significance of clinical outcomes, the use of black cohosh appears to be safe, but ineffective for treating menopausal hot flashes.

" Flap interface particles " are a finding whose clinical significance is undetermined.

Microfolding has been reported as " an almost unavoidable complication of LASIK " whose " clinical significance appears negligible.

Before an appraisal, the Advisory Committee on Topic Selection ( ACTS ) draws up a list of potential topics of clinical significance for appraisal.

Muscle weakness is now recognized as an uncommon though serious complication of steroid therapy, with most of the synthetic adrenal corticosteroids in clinical use.

He showed convincingly that anxiety is a learned ( conditioned ) reaction and is the basis of experimental and clinical neuroses and assumed, therefore, that the neuronal changes which underlie the neuroses are functional and reversible.

Although we are still far from a complete understanding of these problems, as a first approximation, it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic-cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances, in experimental and clinical neurosis, and as the result of psychopharmacological agents.

Then, too, the utmost clinical flexibility is necessary in judiciously combining carefully timed family-oriented home visits, single and group office interviews, and appropriate telephone follow-up calls, if the worker is to be genuinely accessible and if the predicted unhealthy outcome is to be actually averted in accordance with the principles of preventive intervention.

My aim in mentioning this factor obviously is not to give license to `` wild therapy '' but rather to encourage us to use the time-honored clinical casework skills we already possess, and to use them with greater confidence, precision, and professional pride.

Intermarriage, which is generally regarded as a threat to Jewish survival, was regarded not with horror or apprehension but with a kind of mild, clinical disapproval.

Abraham Lincoln suffered from " melancholy ", a condition which now is referred to as clinical depression.

Ataxia is a non-specific clinical manifestation implying dysfunction of the parts of the nervous system that coordinate movement, such as the cerebellum.

An undifferentiated arthritis is an arthritis that does not fit into well-known clinical disease categories, possibly being an early stage of a definite rheumatic disease.

To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

The majority of studies indicate antibiotics do not interfere with contraceptive pills, such as clinical studies that suggest the failure rate of contraceptive pills caused by antibiotics is very low ( about 1 %).

Unlike mainstream medicine, CAM often lacks or has only limited experimental and clinical study ; however, scientific investigation of CAM is beginning to address this knowledge gap.

A systematic 2003 review of controlled clinical trials related to the Alexander Technique found two reputable studies suggesting the Alexander Technique is effective in reducing the disability of patients suffering from Parkinson ’ s disease and improving pain behaviour and disability in patients with back pain, and concluded that the evidence supporting the effectiveness of the Alexander Technique is encouraging but not convincing.

Inert placebos can have significant antidepressant effects, and so to establish a substance as an " antidepressant " in a clinical trial it is necessary to show superior efficacy to placebo.

Analytical chemistry plays an increasingly important role in the pharmaceutical industry where, aside from QA, it is used in discovery of new drug candidates and in clinical applications where understanding the interactions between the drug and the patient are critical.

However, there is limited evidence that mistletoe's effects on the immune system help the body fight cancer .... At present, the use of mistletoe cannot be recommended outside the context of well-designed clinical trials.

The use of a maximum dose of ACE inhibitors in such patients ( including for prevention of diabetic nephropathy, congestive heart failure, prophylaxis of cardiovascular events ) is justified, because it improves clinical outcomes, independent of the blood pressure-lowering effect of ACE inhibitors.

This has led to decreased use of captopril in clinical setting, although it is still used in scintigraphy of the kidney.

Gepirone ( Ariza, Variza ) is also in clinical development.