He also created the first bluetongue vaccine, which was developed from an attenuated BTV strain.

The first occasion was in 1755 when, stimulated by his imperious consort Louisa Ulrika of Prussia ( sister of Frederick the Great ), he tried to regain a portion of the attenuated prerogative, and nearly lost his throne in consequence.

Sabin first tested his live attenuated oral vaccine at the Chillicothe Ohio Reformatory in late 1954.

While at The Wistar Institute, Koprowski created the world's first polio vaccine, based on oral administration of attenuated polio virus.

It was the first and ( as of 2007 ) the only live attenuated vaccine for influenza available outside of Europe.

He published about 250 papers dealing with ( 1 ) factors slowing the growth of tubercle bacilli that might account for the lengthy duration of treatment, including the first paper on the effects of anaerobic culture ; ( 2 ) with Jean Dickinson on post-antibiotic effects to account for the success of intermittent drug dosage ; ( 3 ) the curious characteristics of attenuated South Indian strains of TB ; ( 4 ) the response to treatment when the strains were initially resistant to the drugs allowing identification of the action of individual drugs.

The BCG vaccine was first used in humans in 1921.

Waldemar Haffkine, a doctor who worked in Bombay, India, was the first to invent and test a plague vaccine against bubonic plague in 1897.

* Jonas Salk ( 1934 ), Developed the first polio vaccine

Dukoral, an orally administered, inactivated whole cell vaccine, has an overall efficacy of about 52 % during the first year after being given and 62 % in the second year, with minimal side effects.

The Russian-born bacteriologist Waldemar Haffkine developed the first cholera vaccine around 1900.

* 1954 – The first mass inoculation of children against polio with the Salk vaccine begins in Pittsburgh.

Pasteur produced the first vaccine for rabies by growing the virus in rabbits, and then weakening it by drying the affected nerve tissue.

The vaccine had been tested only on 11 dogs before its first human trial.

This vaccine was first used on 9-year old Joseph Meister, on July 6, 1885, after the boy was badly mauled by a rabid dog.

The first one to be developed was a live vaccine.

In 1909, Frederick F. Russell, a U. S. Army physician, developed an American typhoid vaccine and two years later his vaccination program became the first in which an entire army was immunized.

Smallpox was likely the first disease people tried to prevent by purposely inoculating themselves with other types of infections, and was the first disease for which a vaccine was produced.

French scientist Louis Pasteur developed the first effective vaccine for anthrax in 1881 .< ref >

On March 4, 2009, the United States Department of Agriculture ( USDA ) granted Epitopix a conditional license for the first E. coli O157 vaccine for cattle in the U. S.

In July 1921, at the Pasteur Institute in Lille, Albert Calmette and Camille Guérin discovered the first anti-tuberculosis vaccine, known as BCG (" Bacille de Calmette et Guérin ").

In the years 1770 till 1790 at least six people who had contact with a cow had tested independently the possibility of using the cowpox vaccine as an immunization for smallpox in humans for the first time ; among them the English farmer Benjamin Jesty, in Dorset, in 1774 and the German teacher Peter Plett in 1791.

The first Nobel Prize in Physiology or Medicine was awarded in 1901 to the German physiologist Emil Adolf von Behring, for his work on serum therapy and the development of a vaccine against diphtheria.

* 1952 – Jonas Salk develops the first polio vaccine ( available in 1955 )

* 2006 – Second rotavirus vaccine approved ( first was withdrawn )

The smallpox vaccine was the first successful vaccine to be developed.

( 2006 ) used extracts and excretory-secretory products from first stage larvae to produce an oral vaccine.

Being somewhat delicate in health, at the age of sixteen he was sent to Southern Europe, for which he at once developed a passion, so that he spent nearly all of the following ten years abroad, at first in Italy, then in Greece, Egypt, Asia Minor, and Palestine.

He was an ardent champion of the Brown & Sharpe Apprentice Program and personal counselor to countless able men who first developed their industrial talents with the company.

On Thursday, the first day of the Masters, the contest between Palmer and Player developed instantly.

The first major groups of amphibians developed in the Devonian period from lobe-finned fish similar to the modern coelacanth and lungfish, which had evolved multi-jointed leg-like fins with digits that enabled them to crawl along the sea bottom.

The first version of the robot was first developed back in 2003.

Agnostida is an order of arthropod which first developed near the end of the Early Cambrian period and thrived during the Middle Cambrian.

Asteroids is also the first game to use Atari's " QuadraScan " vector-refresh system ; a full-color version known as " Color-QuadraScan " was later developed for games such as Space Duel and Tempest.

It seems that when the Asparagales first diverged they developed simultaneous microsporogenesis, which the ' lower ' Asparagale families retain.

The practices of total war, developed by Sherman in Georgia, the experimental use of the first usable predecessor of the machine gun and of trench warfare around Petersburg, all foreshadowed World War I in Europe.

The first charter of human rights by Cyrus the Great as understood in the Cyrus cylinder is often seen as a reflection of the questions and thoughts expressed by Zarathustra and developed in Zoroastrian schools of thought of the Achaemenid Era of Iranian history.

Since this picture was first developed by Ernst Stueckelberg, and acquired its modern form in Feynman's work, it is called the Feynman-Stueckelberg interpretation of antiparticles to honor both scientists.

Throughout European history, philosophers such as Aristotle and Thomas Aquinas, among others, contemplated the possibility that souls exist in animals, plants, and people ; however, the currently accepted definition of animism was only developed in the 19th century by Sir Edward Tylor, who created it as " one of anthropology's earliest concepts, if not the first ".

The term Animism appears to have been first developed as animismus by German scientist Georg Ernst Stahl, circa 1720, to refer to the " doctrine that animal life is produced by an immaterial soul.

However, it does seem clear that his first notable work, Summa Quoniam Homines, was completed somewhere between 1155 and 1165, with the most conclusive date being 1160, and likely was developed through his lectures at the school in Paris.

" Ever since the time of my ancestor Ali, the first Imam, that is to say over a period of thirteen hundred years, it has always been the tradition of our family that each Imam chooses his successor at his absolute and unfettered discretion from amongst any of his descendants, whether they be sons or remote male issue and in these circumstances and in view of the fundamentally altered conditions in the world in very recent years due to the great changes which have taken place including the discoveries of atomic science, I am convinced that it is in the best interest of the Shia Muslim Ismailia Community that I should be succeeded by a young man who has been brought up and developed during recent years and in the midst of the new age and who brings a new outlook on life to his office as Imam.

These three propositions were further developed by his followers, who maintained that God revealed Himself in a threefold revelation, the first in the Biblical patriarch Abraham, marking the epoch of the Father ; the second in Jesus Christ, who began the epoch of the Son ; and the third in Amalric and his disciples, who inaugurated the era of the Holy Ghost.

The first sulfonamide and first commercially available antibacterial antibiotic, Prontosil, was developed by a research team led by Gerhard Domagk in 1932 at the Bayer Laboratories of the IG Farben conglomerate in Germany.

After the team had developed a method of purifying penicillin to an effective first stable form in 1940, several clinical trials ensued, and their amazing success inspired the team to develop methods for mass production and mass distribution in 1945.

While Aristotle likewise identifies the first two characteristics, St. Thomas conceives of the third as an appropriation from principles developed by neo-Platonic and Augustinian thinkers.

The Aster CT-80, an early home / personal computer developed by the small Dutch company MCP ( later renamed to Aster Computers ), was sold in its first incarnation as a kit for hobbyists.

Dedicated anti-tank vehicles made their first major appearance in the Second World War as combatants developed effective armored vehicles and tactics.

In 1949, the company developed magnetic recording tape and in 1950, sold the first tape recorder in Japan.

In 1824 to reduce the impact of this destructive electrolytic action on ships hulls, their fastenings and underwater equipment, the Victorian scientist-engineer Sir Humphry Davy, developed the first and still most widely used marine electrolysis protection system.