Before the actual process of cell death is precipitated by enzymes, apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway.

SMAC binds to inhibitor of apoptosis proteins ( IAPs ) and deactivates them, preventing the IAPs from arresting the apoptotic process and therefore allowing apoptosis to proceed.

# Chromatin undergoes condensation into compact patches against the nuclear envelope ( also known as the perinuclear envelope ) in a process known as pyknosis, a hallmark of apoptosis.

Whether this whole process resembles animal apoptosis closely enough to warrant using the name apoptosis ( as opposed to the more general programmed cell death ) is unclear.

Another biologically important process that occurs during development is apoptosis — programmed cell death or " suicide.

HAMLET ( human alpha-lactalbumin made lethal to tumor cells ) is a molecular complex derived from human breast milk that kills tumor cells by a process resembling programmed cell death ( apoptosis ).

The involvement of the proteasome in this process is indicated by both the increase in protein ubiquitination, and of E1, E2, and E3 enzymes that is observed well in advance of apoptosis, During apoptosis, proteasomes localized to the nucleus have also been observed to translocate to outer membrane blebs characteristic of apoptosis.

Cytochrome c is also an intermediate in apoptosis, a controlled form of cell death used to kill cells in the process of development or in response to infection or DNA damage.

Following apoptosis, the dying cells need to be taken up into the surrounding tissues by macrophages in a process called efferocytosis.

Other cells will spontaneously shed their acrosome during the process of apoptosis / necrosis.

Atrophy is the general physiological process of reabsorption and breakdown of tissues, involving apoptosis on a cellular level.

The orderly timing of cell growth, cell migration, and programmed cell death (" apoptosis ") has been studied extensively and the genes that control the process are being elucidated.

When the glutamate concentration around the synaptic cleft cannot be decreased or reaches higher levels, the neuron kills itself by a process called apoptosis.

If DNA damage is too severe, ATM will mediate the process of programmed cell death ( apoptosis ) to eliminate the cell and prevent genomic instability.

Cells which are apoptotic ( i. e. in the process of apoptosis ) no longer actively manage the distribution of phospholipids in their outer membrane and hence begin to display negatively charged phospholipids, such as phosphatidyl serine, on the cell surface.

Cells sometimes enter a state of resistance to signals sent, as part of a process called apoptosis, to instruct cells to destroy themselves.

The mechanism by which AGEs induce damage is through a process called cross-linking that causes intracellular damage and apoptosis.

The process arrests tumor growth, as only one additional nucleoside can be attached to the " faulty " nucleoside, resulting in apoptosis.

A concept of responsibility is in process of articulation and establishment.

An approach that has appealed to some choreographers is reminiscent of Charles Olson's statement of the process of projective verse: `` one perception must immediately and directly lead to a further perception ''.

According to Katherine Litz, `` the becoming, the process of realization, is the dance ''.

The process stipulates that the choreographer sense the quality of the initial movement he has discovered and that he feel the rightness of the quality that is to follow it.

She, too, is concerned with `` the becoming, the process of realization '', but she does not think in terms of subtle variations of spatial or temporal patterns.

In its place is a passionate consciousness grasped and molded to feelings of positive or negative values even as the actions of one's life are determined by constellations of process in which one is caught.

But it is a clumsy and wasteful process: it can produce negative results but not much that is positive.

In the case of social decay, form is displaced simply by the process of dissolution with no form at the terminus of the process.

Within institutions there is a marked decline of the process of persuasion and the substitution of a force-fear process which masquerades as the earlier one of persuasion.

The continuing modernization of these forces is a costly but necessary process.

Social process is always anchored in past predisposition ; ;

Britain in the nineteenth century is a textbook designed `` to give the sense of continuous growth, to show how economic led to social, and social to political change, how the political events reacted on the economic and social, and how new thoughts and new ideals accompanied or directed the whole complicated process ''.

Each year another grade is added to the process, until finally all 12 grades are integrated.

But it is in the process of so doing because it apparently gives priority to trying to downgrade John F. Kennedy.

In still others which are barely on the threshold of the transition into modernity, the decade can bring significant progress in launching the slow process of developing their human resources and their basic services to the point where an expanded range of developmental activities is possible.

Aid is a long-term process

It is an answer in its way, individual and highly dramatic, to the charge that the democratic process is necessarily vicious in its campaign characteristics.

But this we know: Here is a great life that in every area of American politics gives the American people occasion for pride and that has invested the democratic process with the most decent qualities of honor, decency, and self-respect.

It is but part of the whole process within the Department that goes into the making of the final recommendation to the appeal board.

It was recognized years ago that the transition from daytime to nighttime propagation conditions, and vice versa, is not an instantaneous process, but takes place over periods of time from roughly 2 hours before sunset until about 2 hours after sunset, and again from roughly 2 hours before sunrise until some 2 hours after sunrise.

The effect is that the platform returns from an off-level position at a rapid rate until it is nearly level, at which point the platform is controlled by a proportional servo with low enough frequency response so that the noise has little effect on the leveling process.

The integumentary structure contains some typical characteristics common to terrestrial vertebrates, such as the presence of highly cornified outer layers, renewed periodically through a moulting process controlled by the pituitary and thyroid glands.

While administrative decision-making bodies are often controlled by larger governmental units, their decisions could be reviewed by a court of general jurisdiction under some principle of judicial review based upon due process ( United States ) or fundamental justice ( Canada ).

In fact, as their synthesis is controlled by a template directed process in most in vivo systems all biopolymers of a type ( say one specific protein ) are all alike: they all contain the similar sequences and numbers of monomers and thus all have the same mass.

Tin bronze was superior to arsenic bronze in that the alloying process itself could more easily be controlled ( as tin was available as a metal ) and the alloy was stronger and easier to cast.

Bt corn is now commercially available in a number of countries to control corn borer ( a lepidopteran insect ), which is otherwise controlled by spraying ( a more difficult process ).

Mixing the ingredients in a carefully controlled process creates a paste that coats and bonds the aggregate particles.

Following unprecedented foreign led and domestic political interference with the CRTC's quasi-judicial independent regulatory process, within 6 months of its original decision, an abrupt CRTC " review " of its policy on third-language foreign services determined to drop virtually all restrictions and adopt a new " open entry " approach to foreign controlled " third language " ( non-English, non-French ) channels.

Computer controlled music is also found in the performance pieces by the Canadian composer Udo Kasemets such as the Marce ( ntennia ) l Circus C ( ag ) elebrating Duchamp ( 1987 ), a realization of the Marcel Duchamp process piece Erratum Musical using an electric model train to collect a hopper-car of stones to be deposited on a drum wired to an Analog: Digital converter, mapping the stone impacts to a score display ( performed in Toronto by pianist Gordon Monahan during the 1987 Duchamp Centennial ), or his installations and performance works ( e. g. Spectrascapes ) based on his Geo ( sono ) scope ( 1986 ) 15x4-channel computer-controlled audio mixer.

Clairvoyance is related to remote viewing, although the term " remote viewing " itself is not as widely applicable to clairvoyance because it refers to a specific controlled process.

Athenian democracy was not only direct in the sense that decisions were made by the assembled people, but also directest in the sense that the people through the assembly, boule and courts of law controlled the entire political process and a large proportion of citizens were involved constantly in the public business.

However, research and knowledge are brought into the design process through the judgment and common sense of designers – by designers " thinking on their feet " – more than through the predictable and controlled process stipulated by the Rational Model.

Arnaz convinced them to allow Desilu to cover all additional costs associated with the filming process, under the stipulation that Desilu owned and controlled all rights to the film.

In this process, ions are implanted at a high enough energy and dose into a material to create a layer of a second phase, and the temperature is controlled so that the crystal structure of the target is not destroyed.

From 1959, in a process that accelerated in 1961, Nehru adopted the " Forward Policy " of setting up military outposts in disputed areas of the Sino-Indian border, including in 43 outposts in territory not previously controlled by India.

The gain medium of a laser is normally a material of controlled purity, size, concentration, and shape, which amplifies the beam by the process of stimulated emission described above.

Boiling the syrup is a tightly controlled process, which ensures appropriate sugar content.

All electronic operations were controlled by a command subsystem which could process any of 29 direct command words or three quantitative word commands for mid-course maneuvers.

In this process also known as the Danka system Buddhist-temples were generally not only a centre of Buddhist practice and learning, but were forced carry out administrative functions thereby also being controlled by the government taming any missionary activities.

The magnitude of A < sub > OL </ sub > is not well controlled by the manufacturing process, and so it is impractical to use an operational amplifier as a stand-alone differential amplifier.

These α subunits are controlled by binding to " cap " structures or regulatory particles that recognize polyubiquitin tags attached to protein substrates and initiate the degradation process.

The process of adding controlled impurities to a semiconductor is known as doping.

Neither workers nor managers really controlled the work process and this created enormous inefficiencies and waste.