In 1567, Swiss physician Paracelsus suggested unidentified substance in mined ore ( identified as radon gas in modern times ) caused a wasting disease in miners, and in England, in 1761, John Hill made the first direct link of cancer to chemical substances by noting that excessive use of snuff may cause nasal cancer.

" The name " Paracelsus " was a pseudonym signifying him the equal or better of Aulus Cornelius Celsus, whose text, which described the use of opium or a similar preparation, had recently been translated and reintroduced to medieval Europe.

The Canon of Medicine, the standard medical textbook that Paracelsus burned in a public bonfire three weeks after being appointed professor at the University of Basel, also described the use of opium, though many Latin translations were of poor quality.

Having experimented with various opium concoctions, Paracelsus came across a specific tincture of opium that was of considerable use in reducing pain.

* early 16th century: Paracelsus, an alchemist by trade, rejects occultism and pioneers the use of chemicals and minerals in medicine.

Paracelsus pioneered the use of chemicals and minerals in medicine.

Paracelsus pioneered the use of chemicals and minerals in medicine.

Andrea Libavius was one of those chymists who was influenced up to a point by the new teachings of Paracelsus in that he accepted the use of the new chemical remedies in medicine advocated by Paracelsus, whilst adhering theoretically to the traditional Aristotelian and Galenist teachings and rejecting the Paracelsist mysticism.

A century later, Paracelsus introduced the use of active chemical drugs ( like arsenic, copper sulfate, iron, mercury, and sulfur ).

The Alphabet of the Magi was an alphabet invented by Theophrastus Bombastus von Hohenheim ( known as Paracelsus ) for the use of engraving angelic names upon talismans.

Paracelsus suggested its use against liver disease, catarrh and stomach upsets.

A potent narcotic by virtue of its high morphine concentration, laudanum was historically used to treat a variety of ailments, but its principal use was as an analgesic and cough suppressant.

The Romantic and Victorian eras were marked by the widespread use of laudanum in Europe and the United States.

A brief uptick in the use of laudanum occurred in the middle of the previous decade when a crop failure and other problems caused the shortage of multi-purpose soluble tablets of morphine, used at highest volume in recent times as an oral, sublingual, or buccally-administered analgesic.

Long-term use of laudanum in nonterminal diseases is discouraged due to the possibility of drug tolerance and addiction.

Planning out his action with great care, Berlioz purchased phials of strychnine and laudanum to use as poisons in the event of a pistol jamming.

For a long time he was held in vague esteem for the success of his cooling ( or rather expectant ) treatment of small-pox, for his laudanum ( the first form of a tincture of opium ), and for his advocacy of the use of " Peruvian bark " in quartan agues, in modern terms, the use of quinine-containing cinchona bark for treatment of malaria caused by Plasmodium malariae.

Stephen realizes how deeply he has offended her, resigns himself to her loss and returns to the use of the alcoholic tincture of laudanum.

Blaylock suffered from severe headaches and was addicted to laudanum, an opiate-based pain reliever in common use at the time, and later committed suicide.

* Jorge and Carlos are Keepers in Aztlan, who frequently mistreat the Lost Boys while they themselves enjoy lavish parties and the use of laudanum, a drug similar to heroin.

Diarrhoea resulting from cyclic or diarrhoea-predominant IBS may not be optimally treated with diphenoxylate or difenoxin, and may not respond to a meaningful degree to loperamide ; thus, diarrhoea and cramping which does not respond to belladonna derivatives and non-centrally-acting soothing and / or stool-desiccating agents are often treated with conservative doses of codeine, especially where paregoric and / or laudanum are not currently in general use.

He was silent a moment, thinking he could use a man this time of year, and if the girl could cook, it would give him more time in the meadows, but he knew nothing about the couple.

The code, which had probably something to do with sex or some other interest, Nicolas was determined to find out and put to use.

As she was rather tired this evening, her simple `` Thank you for the use of your bath '' -- when she sat down opposite him -- spoken in a low voice, came across with coolnesses of intelligence and control.

Steele apparently professed his sentiments in this book too openly and honestly for his own good, since the government was soon to use it as evidence against him in his trial before the House.

The outstanding example was in Garibaldi And The Thousand, where he made use of unpublished papers of Lord John Russell and English consular materials to reveal the motives which led the British government to permit Garibaldi to cross the Straits of Messina.

Modern warfare was born in this campaign -- periscopes, camouflage, booby traps, land mines, extended order, trench raids, foxholes, armored cars, night attacks, flares, sharpshooters in trees, interlaced vines and treetops, which were the forerunners of barbed wire, trip wires to thwart a cavalry charge, which presaged the mine trap, and the general use of anesthetics.

The use of map coordinates was begun when the senior officers began to select tactical points by designating a spot as `` near the letter o in the word mountain ''.

Without a precise knowledge of Germanic philology, however, it is debatable whether their use was not more often a source of confusion and error than anything else.

A credulousness, a distaste for documentation, an uncritical reliance on contemporary accounts, and a proneness to assume a theory as true before adequate proof was provided were all evidences of his failure to comprehend the use of the scientific method or to evaluate the responsibilities of the historian to his reading public.

It was the use of the supernatural that kept them in business.

It may be thought unfortunate that he was called on entirely by accident to perform, if again we may trust the opening of the oratio, for it marks the beginning for us of his use of his peculiar form of witty word play that even in this Latin banter has in it the unmistakable element of viciousness and an almost sadistic delight in verbally tormenting an adversary.

The narrator is an Alsatian serving with the French Army, and he has the same name ( Berger ) that Malraux himself was later to use in the Resistance ; ;

It was a sort of poetic justice that at the time of his own demise a new plot to overthrow the Venezuelan government, reportedly involving the use of Dominican arms by former Venezuelan Dictator Marcos Perez Jimenez, has been uncovered and quashed.

He was delighted to learn that the Post Office Department is now going to expand this service to deliver mail from Representatives in Congress to their constituents without the use of stamps, names, addresses or even zone numbers.

At a recent meeting of the Women's Association of the Trumbull Ave. United Presbyterian Church, considerable use was made of material from The Detroit News on the King James version of the New Testament versus the New English Bible.

The weekly loss is partly counterbalanced by 500 arrivals each week from West Germany, but the hard truth, says Crossman, is that `` The closing off of East Berlin without interference from the West and with the use only of East German, as distinct from Russian, troops was a major Communist victory, which dealt West Berlin a deadly, possibly a fatal, blow.

One effect of the spirited give-and-take of these discussions was to focus attention on practical applications and the necessity of being armed with the facts: knowledge of the destructive force of even the tiniest `` tactical '' atomic weapon would have a bearing on judgments as to the advisability of its use -- to defend Berlin, for example ; ;

Eugene offered Harold his car, to use at any time he cared to, and when this offer was not accepted, the armchair creaked.

I use the phrase advisedly because there was something positively indecent about our relationship.

Another example is the recent cancellation of the F-108, a long-range interceptor with a speed three times as great as the speed of sound, which was designed for use against manned bombers in the period of the mid-1960's.

This aircraft, which was planned for initial operational use about 1965, would be complementary to but likewise competitive with the four strategic ballistic missile systems, all of which are scheduled to become available earlier.

Several efforts were made in this direction, and though not all of them survive to this day, the Brown & Sharpe wire gage system was eventually adopted as the American standard and is still in common use today.

Although Mr. Brown was not himself its inventor ( it was a French idea ), it is typical that his intuition first conceived the importance of mass producing this basic tool for general use.

Between that year and the buying out of Mr. Darling's interest in 1892, a large portion of the company's precision tool business was carried out under the name of Darling, Brown & Sharpe, and to this day many old precision tools are in use still bearing that famous trademark.