Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, TF binds with coagulation factors which then triggers the extrinsic pathway ( via Factor VII ) which subsequently triggers the intrinsic pathway ( XII to XI to IX ) of coagulation.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation of the spoiler, a high pressure zone is created in front of the flap, and this high pressure zone is exploited — two air intakes are revealed upon application that will allow the high pressure airflow to enter ducts that route air to aid in cooling the rear brakes.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon activation by its ligand agrin, MuSK signals via two proteins called " Dok-7 " and " rapsyn ", to induce " clustering " of acetylcholine receptors ( AChR ).

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon activation, Kinross-based interceptors were directed to intercept unknown aircraft by ADC surveillance Radars at Sault Sainte Marie AFS ( P-86 ); Grand Marais AFS ( M-109 ); Calumet AFS ( P-16 ); Alpena AFS ( M-105 ) and Empire AFS ( P-34 ).

Upon arriving at the rim of North Ray Crater, they were away from the LM.

Upon antigen binding, they cluster in large patches, which can exceed 1 micrometer in diameter, on lipid rafts that isolate the BCRs from most other cell signaling receptors.

“ Upon her children I will have no pity, because they are children of whoredom ” ( Hosea 2: 4 ).

Upon his ejection, Mr. Sianis uttered, " The Cubs, they ain't gonna win no more.

Upon reaching Salzburg, however, they found that he was not available and, disillusioned, returned to the United States after spending only 15 days of their planned three years in Europe.

Upon arriving at Archduke Franz Ferdinand's country seat, château Konopiště, on a semi-official visit, they promptly proceeded to do away with one of the Austro-Hungarian heir presumptive's priceless golden pheasants, thereby almost causing an international incident.

Upon further examination, it was concluded that if the marks were bite marks, they did not match the teeth of any of the three convicted.

Upon observation, researchers discovered users unconsciously assuming ELIZA's questions implied interest and emotional involvement in the topics discussed, even when they consciously knew that ELIZA did not simulate emotion.

Upon his arrival in Hollywood, Lang joined the MGM studio and directed the crime drama Fury, starring Spencer Tracy as a man wrongly accused of a crime and then attacked by lynch mob who burn down the jail where he is awaiting trial and it is assumed they killed him in the flames, but did not.

Upon reaching the Cap Rock section of the park, they attempted to cremate Parsons ' corpse by pouring five gallons of gasoline into the open coffin and throwing a lit match inside.

" Upon completing, they may stop collecting, expand the collection to include related items, or begin an entirely new collection.

Upon his return to the astronaut corps in Houston, he played a key role in training Apollo crews to be geologic observers when they were in lunar orbit and competent geologic field workers when they were on the lunar surface.

Upon examining DNA from the moa, they believe that the kiwi is more closely related to its Australian cousins.

Upon reusing these healthy chickens, Pasteur discovered he could not infect them, even with fresh bacteria ; the weakened bacteria had caused the chickens to become immune to the disease, though they had caused only mild symptoms.

Upon gaining 75 % pass marks, they can proceed to the next level.

Upon seeing a chemist's shop, Cleese pondered whether the shop would sell cheese, to which Chapman responded that if they did it would be medicinal cheese and that Cleese would need a prescription to buy some.

Upon arriving in Diriyah, Muhammad bin Saud and Muhammad ibn ʿAbd al-Wahhab concluded an agreement that, together, they would bring the Arabs of the peninsula back to the " true " principles of Islam as they saw it.

Upon Escher's death, his three sons dissolved the Foundation, and they became partners in the ownership of the art works.

Upon the Spaniards ' arrival to the Philippines, they were dismayed to find such a strong Muslim presence on the island, having just expelled the Moors from Spain after centuries of fighting.

Upon leaving the White House, the couple returned to California, where they purchased a home in the wealthy East Gate Old Bel Air neighborhood of Bel Air, Los Angeles, dividing their time between Bel Air and the Reagan Ranch in Santa Barbara, California ; Ronald and Nancy regularly attended Bel Air Presbyterian Church as well.

Upon their arrival in Puerto Rico, they were received by 18, 000 people.

* Upon calling the athlete's name, they have sixty seconds to commence the throwing motion.