When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete.

When used to characterise protein folding, it measures the conformation by determining the overall size of a monolayer of the protein and its density in real time at sub-Angstrom resolution.

When the thiol groups of two cysteine residues ( as in monomers or constituent units ) are brought near each other in the course of protein folding, an oxidation reaction can generate a cystine unit with a disulfide bond (- S-S -).

When a standard-sized octavo book is produced by twice folding a large leaf, two leaves joined at the top will be contained in the resulting fold ( which ends up in the gulley between the pages ).

When faced with competition from the Giants in 1921, the Ex-Collegians brought in a few outsiders before folding, but generally semi-pro teams spent little effort on recruiting.

When he gets on the air the first time after the format change, Johnny comes alive, signaling the change with a loud drag on the playing record ( a fictional cover of "( You're ) Having My Baby " by the Hallelujah Tabernacle Choir ) and literally folding the record album in half.

When a spider bites, the two parts of the chelicerae come together like a folding knife, and when making a threat display or actually preparing to bite, the spider will open the angle of the fangs with the basal portion of chelicerae and also open the angle of the basal portion with the cephalothorax.

Image: Icing_ ( referee ). png | When the puck has crossed the goal line ( and in North American professional hockey, a non-offending player has touched the puck ) the rear official signals icing by folding his arms in front of his chest.

When stored, the Mess Kit Plate is placed on top of the ovoid Meat Can Body, while the stamped folding handle is folded over the inverse side of the plate's center divider, and latched onto the edge of the Body.

When rakes have longer teeth, they may be arranged in the shape of an old-style folding fan.

When the NHL announced in June 1974 that the owners of both the Denver Spurs and Seattle Totems had been granted " conditional " NHL franchises ( neither of which came to fruition ), the WHL announced the same day that it was folding.

When World War II began, he travelled from Africa ( where he was big-game hunting ) to England to join the Army as a " commando folding kayaker ".

When the taffy reaches a 5-or 6-foot length where it might become too heavy for itself and fall off the hook, the puller loops the taffy back over the hook, folding it onto itself and trapping air between the two lengths of taffy.

When first shown on Sardinia and the Paris Auto Show in 1967, the 1100 was advanced in design, featuring a hatchback with folding rear seats, disc brakes, rack and pinion steering, an independent front ( double wishbone ) and rear ( trailing arm ) suspension using Chrysler-style torsion bars ( though Chrysler itself only used them up front ), and a full range of controls.

When a diskos is made, it is usually accompanied by a matching asterisk ( small, folding metal stand used to keep the Aër from disturbing the particles on the diskos ), a spoon ( for distributing Holy Communion to the faithful ), and a spear ( used to cut the Lamb during the Liturgy of Preparation ).

# When not using a blade keep it covered ( sheaths, folding knives, etc.

When two or more subcontractors are working on different parts of a larger overall system, the locked-out device is first secured with a folding scissors clamp that has many padlock holes capable of holding it closed.

When the historian encounters a situation in which he can perceive no visible cause and effect sequence, he should be alert to intuition and unconscious instinct as possible guides.

When the same sequence is equivalent in meaning to I have instructions which I am to leave, dominant stress is ordinarily on instructions.

When 301 of the most advanced model, the " Launch Arco ," are built, an " exodus sequence " starts in which all Launch Arcos blast into space.

When set to the US region, the Neo-Geo version displays the alternative title " Bust a Move " and features anti-drugs and anti-littering messages in the title sequence.

When the Laplace transform is performed on a discrete-time signal ( with each element of the discrete-time sequence attached to a correspondingly delayed unit impulse ), the result is precisely the Z transform of the discrete-time sequence with the substitution of

When analyzing the deformation or motion of solids, or the flow of fluids, it is necessary to describe the sequence or evolution of configurations throughout time.

When a hoop is won, the sequence of play continues as before.

When scientists transfer a gene from one cell into another cell in order to express the new genetic material as a protein in the recipient cell, the cDNA will be added to the recipient ( rather than the entire gene ), because the DNA for an entire gene may include DNA that does not code for the protein or that interrupts the coding sequence of the protein ( e. g., introns ).

When people are asked to make up a random-looking sequence of coin tosses, they tend to make sequences where the proportion of heads to tails stays closer to 0. 5 in any short segment than would be predicted by chance ( insensitivity to sample size ); Kahneman and Tversky interpret this to mean that people believe short sequences of random events should be representative of longer ones.

When a future event ( ex: a coin toss ) is described as part of a sequence, no matter how arbitrarily, a person will automatically consider the event as it relates to the past events, resulting in the gambler's fallacy.

When the result sequence is exhausted ( e. g. there are no more values within the result sequence ), the expression or function fails.

When transcribed, each sequence forms a hairpin loop structure that the N protein can bind to.

When ordered by temperature and when duplicate classes were removed, the spectral types of stars followed, in order of decreasing temperature with colors ranging from blue to red, the sequence O, B, A, F, G, K and M. ( A popular mnemonic for memorizing this sequence of stellar classes is " Oh Be A Fine Girl / Guy, Kiss Me ".

When certain events occur, an interrupt system can signal the processor to suspend processing the current instruction sequence and to begin an interrupt service routine ( ISR, or " interrupt handler ").

When a Hertzsprung-Russell diagram is plotted for an open cluster, most stars lie on the main sequence.

When the enhancer sequence is wrongly placed, these transcription factors are produced at much higher rates.

When a sequence of start bit, 5 data bits and stop bit arrives at the input of the teleprinter, it is converted to a 5-bit word and passed to the printer or VDU.

When you watch the sequence of the landing, it ’ s no longer possible to look the same way at The Longest Day, or even Samuel Fuller's The Big Red One ...

When creating the opening sequence for season nine, they decided to create a new sequence to give birth to the " new X-Files ".

When the " Moral Climate Monitors " come to visit, Stendahl and Pikes arrange to kill each of them in ways that allude to different horror masterpieces, culminating in the murder of Inspector Garrett in a sequence reminiscent of Edgar Allan Poe's " The Cask of Amontillado ".

When the surrounding gas and dust envelope disperses and accretion process stops, the star is considered a pre – main sequence star ( PMS star ).

When Heidegger and Sartre speak of a contrast between being and existence, they may be right, I don't know, but their language is too philosophical for me.

When they express themselves it is incandescent hatred that shines forth, the rage of repudiation, the ecstasy of negation.

When I try to work out my reasons for feeling that this passage is of critical significance, I come up with the following ideas, which I shall express very briefly here and revert to in a later essay.

When the proprietor dies, the establishment should become a corporation until it is either acquired by another proprietor or the government decides to drop it.

When the reactionary response is thus bolstered by an intellectual defense, the characteristics of that defense are explicable only in terms of the basic attitudes of unanalyzed reaction.

When I take over Taliesin, the first thing I'll do is fire you ''.

When someone in the audience rose and asked how does it feel to be a celebrity, Carl said, `` A celebrity is a fellow who eats celery with celerity ''.

When decision makers act within this frame they determine whether a claim put forward in the name of religion is to be accepted by the larger community as appropriate to religion.

When we consider the disorganized state of the world community, and the legacy of predispositions adversely directed against all who are identified as Jews, it is obvious that the struggle for the minds and muscles of men needs to be prosecuted with increasing vigor and skill.

When we turn to Aristotle's ideas on the moral measure of literature, it is at once apparent that he is at times equally concerned about the influence of the art.

When their faith in civil liberties is tested against strong pressures of social expediency in specific issues, e.g., suppression of `` dangerous ideas '', many waver and give in.

There is, of course, nothing new about dystopias, for they belong to a literary tradition which, including also the closely related satiric utopias, stretches from at least as far back as the eighteenth century and Swift's Gulliver's Travels to the twentieth century and Zamiatin's We, Capek's War With The Newts, Huxley's Brave New World, E. M. Forster's `` The Machine Stops '', C. S. Lewis's That Hideous Strength, and Orwell's Nineteen Eighty-Four, and which in science fiction is represented before the present deluge as early as Wells's trilogy, The Time Machine, `` A Story Of The Days To Come '', and When The Sleeper Wakes, and as recently as Jack Williamson's `` With Folded Hands '' ( 1947 ), the classic story of men replaced by their own robots.

When I first came across Samuel Johnson's pronouncement, `` the remedy for the ills of life is palliative rather than radical '', it seemed to me to sum up the profoundest of political and social truths.

When all else fails, it is argued that open sessions slow down governmental operations.

When a person has thoughtlessly or deliberately caused us pain or hardship it is not always easy to say, `` Just forget it ''.

When a person meets God's requirements for the experience of forgiveness he is forgiven.

When I hold my son he stiffens his whole body in my arms until he is as straight and stiff as a board.

When different colors are used, she is just as likely to color trees purple, hair green, etc..

When we become firm enough to stand for those ideals which we know to be right, when we become hard enough to refuse to aid nations which do not permit self-determination, when we become strong enough to resist any more drifts towards socialism in our own Nation, when we recognize that our enemy is Communism not war, and when we realize that concessions to Communists do not insure peace or freedom, then, and only then will we no longer be `` soft ''.

When one powerful nation strives to emulate the success of another, it is only natural.

When a man is laid to rest, he is entitled to stay put.

When I talked to Ching about it, he said, Everyone can learn, if he is not a Reactionary or lazy.