Without the gene, the mice exhibited masculine sexual behavior and attraction toward urine of other female mice.

Without a normal gene to provide normal proteins in addition to the abnormal proteins caused by a MECP2 mutation, the XY karyotype male fetus is unable to check the development of the disease, hence the failure of many male fetuses with a MECP2 mutation to survive to term.

Without genetic testing, some carriers are misidentified as having white markings due to another gene, while some are even classified as solids.

Without such a concentrated medulla, water has less of an osmotic driving force to leave the collecting duct system, ultimately resulting in increased urine production.

Without detailed information on the critical local routings, it is very difficult to ascertain what capacity remains in the duct network and which connections run through it.

Without saying or seeming to say that in portraying the Sartoris and the Compson families Faulkner's chief concern is social criticism, we can say nevertheless that through those families he dramatizes his comment on the planter dynasties as they have existed since the decades before the Civil War.

Without a precise knowledge of Germanic philology, however, it is debatable whether their use was not more often a source of confusion and error than anything else.

Without such forward planning, investment funds are wasted because manufacturing facilities are completed before there is power to operate them or before there is transport to service them ; ;

A true university, like most successful marriages, is a unity of diversities Without forcing all components into a single pattern, the preparation of a master plan is an opportunity to consider interrelation of knowledge at its highest level, which a university -- in contrast to a multiversity -- should stand for.

Without losing the distinctive undertow of Brahmsian rhythm, the pacing is firm and the over-all performance has a tightly knit quality that makes for maximum cumulative effect.

`` Without any officious and improper interference on the subject, the price of labor or the wages of mechanics will be regulated by the demand for the manufactured article and the value of that which is paid for it ; ;

Without such a declaration, Paine concluded, “ he custom of all courts is against us, and will be so, until, by an independence, we take rank with other nations .”

Without this money creation benefit, it is actually more expensive to outsource the IT operations as the outsourcing adds a layer of management and increases overhead.

Chapter 17 of William Bates ' 1920 book Perfect Sight Without Glasses, in which the author argues that observation of the sun is beneficial to those with poor vision, includes a figure of somebody " Focussing the Rays of the Sun Upon the Eye of a Patient by Means of a Burning Glass.

Without a freewheel, coasting is impossible, so when the rear wheel is moving, the cranks are moving.

Without diagnosis and treatment, the infection can be fatal in one to six days ; mortality in untreated cases is approximately 100 %.

Without clear documentation, software can be hard to use — especially if it is very specialized and relatively complex like Photoshop or AutoCAD.

Without protected memory, it is possible that a bug in one program will alter the memory used by another program.

Without salvation from sin ( see below ), a person's separation from God is permanent, causing such a person to enter Hell in the afterlife.

Guided by Arkyn, Corum, Rhalina and companion Jhary-a-Conel cross the planes and encounter the King Without A Country, the last of his people who in turn is seeking the City in the Pyramid.

According to Tibor R. Machan, " Without a market in which allocations can be made in obedience to the law of supply and demand, it is difficult or impossible to funnel resources with respect to actual human preferences and goals.

: Without doubt this is the most important work on general algebra that the Annalen has ever published.

Without experience of meditation, one's knowledge of the world is too limited to fully understand dukkha, as required by the first noble truth, and proceed to enlightenment.

" Without these questions there is no clear fulcrum on which to balance law, politics, and the practice of arbitration — in fact, no common assumptions of all participants — so the ability to formulate the questions are prior to rights balancing.

Without a price mechanism, socialism lacks the means to relate consumer satisfaction to economic activity, it is argued.

The scene in which Lee states that his style was the style of " Fighting Without Fighting " and then lures Parsons into boarding a dinghy is based upon a famous anecdote involving the 16th century samurai Tsukahara Bokuden.

Without this suffix, a countable noun is understood to be singular.

Without further inquiry, Pike jumped to the conclusion that Robinson was guilty, and, following the honorable route that would eventually lead to the dueling ground, sent a message to Robinson through his friends, demanding that he either confirm or deny his complicity.

Without exception Hino's brothers turned to either one or both of their father's occupations, but Hino showed a talent for neither and instead spent most of his time on the beach where he repaired nets and proved immensely popular as a storyteller.

A nucleotide is composed of a nucleobase ( nitrogenous base ), a five-carbon sugar ( either ribose or 2-deoxyribose ), ref > Without the phosphate group, the nucleobase and sugar compose a nucleoside.

Without the outward pressure generated by the fusion of hydrogen to counteract the force of gravity, it contracts until either electron degeneracy becomes sufficient to oppose gravity or the core becomes hot enough ( around 100 megakelvins ) for helium fusion to begin.

Without a home in either of the two major parties, Tyler sought an issue that could create a viable third party to support his bid for the presidency in 1844.

Without the diacritic, the sequence can represent either a diphthong () or two vowels in hiatus ().

Many revolution-themed songs, such as " Ode to the Motherland ", " Sailing the Seas Depends on the Helmsman ", " The East Is Red " and " Without the Communist Party, There Would Be No New China " were either written or became extremely popular during this period.

Without it, there might not have been either That Was the Week That Was or Private Eye magazine, which originated at the same time, and that partially survived due to financial support from Peter Cook, and served as the model for the later American Spy Magazine.

Without either Toxin A or Toxin B, C. difficile may colonize the gut but is unlikely to cause pseudomembranous colitis.

Without Jerry, they chose not to use his brother Colin either.

Without replenishment, land suffers from nutrient depletion and becomes either unusable or suffers from reduced yields.

Without Liut, the Whalers had to either stick with Sidorkiewicz, which they did, or use the unproven rookie, Kay Whitmore, in goal.

Without any sign of forced entry into their dwellings, the women were assumed to have either known their killer or voluntarily allowed him into their homes.

Without any sign of forced entry into their dwellings, the women were assumed to have either known their assailant or have voluntarily allowed them into their homes, believing them to be an apartment maintenance man, delivery man, or some other service man.

Without the elevation, many of these regions would likely feature either tropical or humid subtropical climates.

Without revealing to Leblois any secret document, even the " petit bleu ," he told him that he had discovered Esterhazy's crime and the innocence of Dreyfus ; he authorized him, in case of necessity, to inform the government, but absolutely forbade him to apprise either the brother or the lawyer of Dreyfus.

Without letting himself be either intimidated or flattered, he related clearly, sincerely, and succinctly, the story of his discovery.

" Absence Without Leave " ( AWOL ) can refer to either desertion or a temporary absence.

Without having the ability to closely examine and feel the note due to it being sealed inside the slab, many collectors are not comfortable accepting the opinion of others as to the grade and may either elect not to purchase the note or to cut it out of the slab for examination.

Without the elevation, many of these regions would likely feature either tropical or humid subtropical climates.

Without lapsing into moral or artistic simplism, shoddy craftsmanship, Madison Avenue venality, or either false or real naiveté, he nevertheless aspires to a fiction more democratic in its appeal than such late-Modernist marvels as Beckett's Texts for Nothing ...

Without the support of a mass movement that would have given the majority an effective voice, individual insurgents were either marginalized or coopted.

In his book Blood Relations: Chosen Families in Buffy and Angel, Jes Battis simply observed that the relationship completes the already present “ circuit of erotic incest within Buffy and Angel .” Jean Lorrah, in her academic essay " A World Without Love: The Failure of Family in Angel ," agreed with previous statements, further noting that Connor is the product of a relationship with incestuous tones: ” Angel is seduced by Darla, formerly his sire ( mother ), now his granddaughter Connor ’ s life, unbeknownst to either parent, has begun .”

Without either of these two conditions, there is no need for signals as the problem is merely one of communication.

Without the support of either the Irish or Scandinavians, Howth was isolated and fell to the Normans in 1177.