Without diagnosis and treatment, the infection can be fatal in one to six days ; mortality in untreated cases is approximately 100 %.

Without treatment, an acute attack of gout usually resolves in five to seven days.

Without treatment, episodes of acute gout may develop into chronic gout with destruction of joint surfaces, joint deformity, and painless tophi.

Without timely treatment, these new blood vessels can bleed, cloud vision, and destroy the retina.

Without special treatment after circulation is restarted, full recovery of the brain after more than 3 minutes of clinical death at normal body temperature is rare.

Without treatment, the disease is invariably fatal, with progressive mental deterioration leading to coma and death.

Without treatment, about 12-13 % of patients will spontaneously improve over time, 40-50 % will get worse and the rest will be relatively stable.

Without treatment, symptoms may worsen, leading ( in extreme cases ) to suicide attempts.

Without renouncing its " Third-worldism " position, it extended the treatment of its subjects, concentrating on international economic and monetary problems, strategic relations, the Middle-East conflict, etc.

Without effective water treatment, a cooling water system can suffer from scale formation, corrosion and fouling and may become a breeding ground for harmful bacteria such as those that cause Legionnaires ' Disease.

Without treatment, the individual with schizoaffective disorder may further worsen in their abnormal emotions and delusional thought processes.

Without urgent treatment these result in sudden death.

Without necessarily receiving great remuneration ( pay differentials under Zhivkov were within the 5: 1 range, with the overwhelming majority of salaries being within the 3: 1 range ), Party members and DS informers received very significant perquisites which involved access to accommodation, luxury imported goods, hard currency, the ability to travel abroad, superior medical and dental treatment and unhindered entry to higher education for their children.

Without insight into what the problem is, it is much harder for behavioral therapy to be the key to the successful treatment of compulsive hoarders.

Without treatment, mortality in infants with galactosemia is about 75 %.

Without treatment, persons afflicted often appear to walk on their ankles, or on the sides of their feet.

Through its breakthrough price offers to developing country governments and leading NGOs such as Doctors Without Borders ( MSF ) and Oxfam, along with its keen participation in PEPFAR, the Global Fund, the Clinton Foundation's HIV / AIDS Initiative and other major donor programs fighting HIV / AIDS in Africa and elsewhere in the resource-poor world, Cipla has played an unparalleled leadership role in ensuring access to antiretroviral treatment ( ART ) rose from under 10, 000 on the entire African continent at the time of its $ 350 per patient per year offer in 2001, to over 8 million in the developing world by 2012.

Without treatment, children often die in the first decade of life.

Without much exchange with the ocean outside the Island, the Lake water quality is threatened by runoff from human activities in the surrounding watershed, especially from sewage treatment plants and septic tanks, ocean going ships and small craft plying the lake system.

Without treatment, the disease is often fatal.

Without treatment death usually occurs due to heart failure and respiratory weakness.

Without treatment the disease is particularly lethal in infants and young children.

Without treatment, mortality may approach 1 %, usually within six weeks of onset.

Without treatment, kidney damage occurs and death in the more severe cases.

* Sea Without Shore: A Manual of the Sufi Path, an extensive treatment of the science of tasawwuf.

Without using measures of income adjusted for inflation, they will tend to overstate the effects of economic growth.

Without many new applications, the growth of the United States ' piezoelectric industry suffered.

Without careful moisture and temperature control during manufacture and packaging, the tea may become unfit for consumption, due to the growth of undesired molds and bacteria.

" As he explained with regard to the Latin and Slavic races, " Without war, inferior or decaying races would easily choke the growth of healthy budding elements.

Without their symbionts, coral growth would be too slow for the corals to form significant reef structures.

Without the use of modern day plant breeding techniques, Russell took to ruthlessly pulling out any plants which he deemed to be unacceptable in growth or display.

Without making full use of its labour and land resources, the Ottomans were in a strong position for long-term growth.

Without our work, the grassland would succeed to scrub and there would probably only be half an acre or so of grassland at the south end where salt spray and wind would suppress the growth of scrub.

Without the Olympic incentive, the sport's growth in America collapsed and the game remained dormant.

Without meditation work cannot be performed in a way which conduces to spiritual growth.

The United Nations, to Powell, was an " absurdity and a monstrosity " by its very nature because it sought to preserve the international status quo without the use of force but that the " rise and growth and disappearance of nations is mediated by force ... Without war the sovereign nation is not conceivable ".

Without strong capital markets it would be difficult for our national economy to sustain continued growth ... Securities brokers support the proper functioning of these markets by maintaining a constant flow of debt and equity instruments.

Without significant improvements in governance, economic growth will not be sustainable.

Without these, a turtle's growth can be stunted and its immune system weakened.

Without soil as a buffer, any failure to the hydroponic system leads to rapid plant death.

Without reverse transcriptase, the viral genome would not be able to incorporate into the host cell, resulting in the failure of the ability to replicate.

Without a normal gene to provide normal proteins in addition to the abnormal proteins caused by a MECP2 mutation, the XY karyotype male fetus is unable to check the development of the disease, hence the failure of many male fetuses with a MECP2 mutation to survive to term.

It was possible that Bogarde's refusal to enter into a marriage of convenience was a major reason for his failure to become a star in Hollywood, together with the critical and commercial failure of Song Without End.

Without this bonding, the fibers can ' slip ' in the matrix and localised failure would ensue.

Without such damping, fatigue cracking near the rear main bearing journal may occur, leading to engine failure.

H. E. Lessing has shown by circumstantial evidence that the climate anomaly of 1816, Year Without a Summer, due to the eruption of Tambora that impaired transportation in Europe by crop failure and starvation of horses, was the cause of Drais ' invention of the velocipede.

Shaffer later wrote in the introduction to his 1982 Collected Plays: " Without much conviction, but with the sort of energy which Tynan always elicited from me, I described my idea of a party given in a London flat, played in Chinese darkness -- full light -- because of a power failure in the building.

Without any publicity, the record sunk and the band disbanded. Raul Seixas was totally shaken by the failure of the Panthers, and his return to Salvador.

Without this feature, digital clocks will reset themselves incorrectly ( usually to midnight ) when power is restored, causing a failure to trigger the alarm.

Without careful maintenance superheaters are prone to a particular type of hazardous failure in the tube bursting at the U-shaped turns in the superheater tube.

Torres García's disappointment with regard to the creation of the group and its failure is found in the published manuscript La ciudad sin nombre (" The City Without Name "), in which Torres García reflects his disillusion with the situation.

Without treatment, children with cystinosis are likely to experience complete kidney failure by about age ten.

Without further geographical expansion, opportunities for high profits were reduced and the flow of British capital dried up, contributing to a wider downturn caused by drought and mercantile failure.

The best example of this is Without a Trace, which was considered a failure on ProSieben but is quite successful on kabel eins.