* 1492 – Spain gives Christopher Columbus his commission of exploration.

* 1492 – Christopher Columbus sets sail from Palos de la Frontera, Spain.

Andrea Alciato ( May 8, 1492 – January 12, 1550 ), commonly known as Alciati ( Andreas Alciatus ), was an Italian jurist and writer.

* 1492 – Spain and Christopher Columbus sign the Capitulations of Santa Fe for his voyage to Asia to acquire spices.

Bayezid II was born in Dimetoka Palace ( now Didymoteicho ) in Thrace as the son of Mehmed II ( 1432 – 81 ) and Valide Sultan Mükrime Hatun, the daughter of Süleyman Bey, the sixth ruler of Dulkadirids, who died in 1492.

Eventually, the Knights handed Cem over to Pope Innocent VIII ( 1484 – 1492 ).

* Casimir IV Jagiellon ( 1427 – 1492 ), Polish king

* 1492 – Christopher Columbus becomes the first European to set foot on the island of Hispaniola, now Haiti and the Dominican Republic.

* 1549 – Marguerite of Navarre, wife of Henry II of Navarre ( b. 1492 )

* 1492 31 March – After conquering Granada, the Catholic Monarchs sign the Alhambra decree ordering the expulsion of the Jews from Spain, to be take effect from 31 July 1492.

* 1492 Summer – After the death of the former Duke, his son and heir, Juan Alfonso Perez de Guzman, 3rd Duke of Medina Sidonia saw his lordship over Gibraltar reluctantly renewed by the Catholic Monarchs.

* 1492 – Reconquista: the emirate of Granada, the last Moorish stronghold in Spain, surrenders.

* 1492 – Ferdinand and Isabella The Catholic Monarchs enter Granada, completing the Reconquista.

* 1492 – The first grammar of the Spanish language is presented to Queen Isabella I.

Lorenzo de ' Medici ( 1 January 1449 – 9 April 1492 ) was an Italian statesman and de facto ruler of the Florentine Republic during the Italian Renaissance.

* 1492 – Queen Isabella of Castille issues the Alhambra decree, ordering her 150, 000 Jewish subjects to convert to Christianity or face expulsion.

At this time, Michelangelo sculpted the reliefs Madonna of the Steps ( 1490 – 1492 ) and Battle of the Centaurs ( 1491 – 1492 ).

Following the breakup of Mali a local leader named Sonni Ali ( 1464 – 1492 ) founded the Songhai Empire in the region of middle Niger and the western Sudan and took control of the trans-Saharan trade.

* 1492 – Peace of Etaples between Henry VII and Charles VIII.

* 1492 – The Ensisheim meteorite, the oldest meteorite with a known date of impact, strikes the earth around noon in a wheat field outside the village of Ensisheim, Alsace, France.

* August 18 – Jami, Persian poet ( d. 1492 )

Persian poets, such as Sa ’ di ( d. 1291 ), Hafiz ( d. 1389 ), and Jami ( d. 1492 ), wrote poems replete with homoerotic allusions.

* Nur ad-Din Abd ar-Rahman Jami ( 1414 – 1492 ), Persian poet

Nur ad-Dīn Abd ar-Rahmān Jāmī () also known as DJāmī, Mawlanā Nūr al-Dīn ' Abd al-Rahmān or Abd-Al-Rahmān Nur-Al-Din Muhammad Dashti who is commonly known as Jami ( August 18, 1414 – November 17, 1492 ), is known for his achievements as a scholar, mystic, writer, composer of numerous lyrics and idylls, historian, and the greatest Persian and Sufi poets of the 15th century.

Saadia Gaon, David ben Merwan al-Mukkamas, Maimonides, and Thomas Aquinas, to name a few, knew of at least some of the Mutazilite work, particularly Avicennism and Averroism, and the Renaissance and the use of empirical methods were inspired at least in part by Arabic translations of Greek, Jewish, Persian and Egyptian works translated into Latin during the Renaissance of the 12th century, and taken during the Reconquista in 1492.

* Antoine Busnois ( – 1492 ), French composer and poet of the early Renaissance Burgundian School.

The heroic exploits of Wallace were passed on to posterity mainly in the form of tales collected and recounted by the poet Blind Harry, the Minstrel (?- 1492 ) whose original, probably oral sources were never specified.

While in the service of the Medici in Florence, Isaac wrote a lament on the death of Lorenzo de ' Medici, Quis dabit capiti meo aquam ( 1492 ), which set words by Lorenzo's favorite poet, Angelo Poliziano.

** Donato Giannotti, Italian political writer and poet ( born 1492 )

Pietro Aretino ( 20 April 1492 – 21 October 1556 ) was an Italian author, playwright, poet and satirist who wielded immense influence on contemporary art and politics and invented modern literate pornography.

" There are also claims that the Welsh poet and genealogist Gutun Owain wrote about Madoc before 1492.

Antoine Busnois ( also Busnoys ) ( c. 1430 – November 6, 1492 ) was a French composer and poet of the early Renaissance Burgundian School.

In 1492 the poet entertained his patron with a dramatic piece, the Triunfo de la fama, written to commemorate the fall of Granada.

* probable-Jacob Acontius, Swiss jurist, theologian, philosopher and engineer ( b. 1492 )

* September 20 – Thomas Manners, 1st Earl of Rutland ( b. 1492 )

** Polidoro da Caravaggio, Italian painter ( b. 1492 )

* August 12 – Francisco de Vitoria, Renaissance theologian ( b. 1492 )

* May 6 – Juan Luís Vives, Spanish scholar ( b. 1492 )

** Berthold Haller, German-born reformer ( b. 1492 )

* May 4 – Lorenzo II de ' Medici, Duke of Urbino ( b. 1492 )

* September 14 – Elizabeth Tudor, daughter of Henry VII of England ( b. 1492 )

* October 5 – Edward Wotton, English zoologist ( b. 1492 )

** Bernal Díaz del Castillo, Spanish conquistador ( b. c. 1492 )

* March 30 – Adam Ries, German mathematician ( b. 1492 )

* October 21 – Pietro Aretino, Italian author ( b. 1492 )

* February 25 – Hirate Masahide, Japanese diplomat and tutor of Oda Nobunaga ( suicide ) ( b. 1492 )

* May 22 – Daniel, Metropolitan of Moscow ( b. c. 1492 )

* December 21 – Marguerite de Navarre, queen of Henry II of Navarre ( b. 1492 )