On the other hand, the process of obsoleting an old product and introducing the new one is usually mighty expensive.

Night after night he stayed with Gunny in the dead of winter, rubbing her with quarts of expensive liniment, fussing over her bran mash as the cook did over charlotte russe, tracking manure on the pretty new carpet when he did come to the house.

Partially through the hiring of expensive foreign player, the new club soon acquired large debts.

Since gene therapy is relatively new and at an experimental stage, it is an expensive treatment to undertake.

Shareholder nominations can only occur at the general meeting itself or through the prohibitively expensive process of mailing out ballots separately ; in May 2009 the SEC proposed a new rule allowing shareholders meeting certain criteria to add nominees to the proxy statement.

It had become too expensive to train new staff members to use BC, and too expensive to maintain in general.

In Britain particularly, good quality building stone became ever more expensive during a period of rapid growth, and it became a common practice to construct prestige buildings from the new industrial bricks, and to finish them with a stucco to imitate stone.

Also, since a DBMS is complex and expensive to build and maintain, it is not economical to build such a new tool ( DBMS ) for every application.

It is expensive to produce a completely new edition of the Britannica, and its editors delay for as long as fiscally sensible ( usually about 25 years ).

To move from vendor A's to vendor B's systems usually meant a very expensive re-entry of almost all design data by hand into the new system.

Isidore of Miletus and Anthemius of Tralles originally planned on a main hall of the Hagia Sophia that measured 230 feet by 250 feet, making it the largest church in Constantinople, but the original dome was nearly 20 feet lower than it was constructed, “ Justinian suppressed these riots and took the opportunity of marking his victory by erecting in 532-7 the new Hagia Sophia, one of the largest, most lavish, and most expensive buildings of all time .” Although Isidore of Miletus and Anthemius of Tralles were not formally educated in architecture, they were scientists that could organize the logistics of drawing thousands of laborers and unprecedented loads of rare raw materials from around the Roman Empire to create the Hagia Sophia for Emperor Justinian I.

Replacement was cost-prohibitive because of the expensive requirement for flight certification ; the legacy hardware used completed the expensive integration and certification requirement for flight, but any new equipment would have had to go through that entire process – requiring extensive tests of the new components in their new configurations – before a single unit could be used in the Space Shuttle program.

Nanotechnology will replace our entire manufacturing base with a new, radically more precise, radically less expensive, and radically more flexible way of making products.

The new china, White House renovations, expensive clothing, and her attendance at the wedding of Charles and Diana, Prince and Princess of Wales, gave her an aura of being " out of touch " with the American people during an economic recession.

Traditional textbooks, aside from being expensive can also be inconvenient and out of date, because of publishers ' tendency to constantly print new editions.

The Stump-jump plough was an Australian invention of the 1870s, designed to cope with the breaking up of new farming land, that contains many tree stumps and rocks that would be very expensive to remove.

He turned his family mansion in Rome into a monastery, St. Agatha in Suburra, endowing it with expensive and precious vessels for use at the altar, and also established a new church, dedicated to Sant ' Eustachio.

Although these agreements changed during the 1980s and beyond, it is still expensive to repeat archive television series on British terrestrial television, as new contracts have to be drawn up and payments made to the artists concerned.

Pipesmokers who wish to sample a wide variety of different tobaccos and blends also might keep a stock of corncobs on hand to permit them to try new flavors without " carryover " from an already-used pipe, or to keep a potentially bad-tasting tobacco from adding its flavor to a more expensive or favored pipe.

However, despite a push for new antibiotic therapies there has been a continued decline in the number of newly approved drugs.

Until the 1970s there was considerable debate within psychiatry on the most appropriate term to use to describe the new drugs.

The new president's program was based on a commitment to bring about a peaceful resolution of Colombia's longstanding civil conflict and to cooperate fully with the United States to combat the trafficking of illegal drugs.

It is widely used in the design of new drugs and materials.

With forest biotopes being irreplaceable source of new drugs ( such as taxol ), deforestation can destroy genetic variations ( such as crop resistance ) irretrievably.

The common names of illicit drugs, and the plants used to obtain them, often undergo a process similar to taboo deformation, because new terms are devised in order to discuss them secretly in the presence of others.

Some people are willing to take their chances to gamble their health on the success of new drugs or old drugs in new situations which may not yet have been fully tested in clinical trials.

In organized studies of new treatments for cancer, the pre-clinical development of drugs, devices, and techniques begins in laboratories, either with isolated cells or in small animals, most commonly rats or mice.

By this time, Parsons's own use of drugs had increased to the extent that new songs were rare and much of his time was diverted to partying with the Stones, who briefly relocated to America in the summer of 1969 to finish their forthcoming Let It Bleed album and prepare for an autumn cross-country tour, their first series of regular live engagements since 1967.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Such cells, tissues and organs would neither trigger an immune response nor require the use of Immunosuppressive drugs Both basic research and therapeutic development for serious diseases such as cancer, heart disease and diabetes, as well as improvements in burn treatment and reconstructive and cosmetic surgery, are areas that might benefit from such new technology.

In the 1950s new psychiatric drugs, notably the antipsychotic chlorpromazine, were designed in laboratories and slowly came into preferred use.

Other event-driven strategies include: credit arbitrage strategies, which focus on corporate fixed income securities ; an activist strategy, where the fund takes large positions in companies and uses the ownership to participate in the management ; a strategy based on predicting the final approval of new pharmaceutical drugs ; and legal catalyst strategy, which specializes in companies involved in major lawsuits.

In the search for new drugs, ion channels are a frequent target.

After seeing Trevor's latest porno film, Bletch decides they need a new pornstar, and Trevor choose Lucille ; he drugs her and tries to rape her as an audition but gets accidentally caught by Robert.

Response strategies typically include the use of different, stronger antibiotics ; however, new strains of MRSA have recently emerged that are resistant even to these drugs.

In October 2011 the Dutch government proposed a new law to the Dutch parliament, that will put cannabis with 15 % THC or more onto the list of hard drugs.

Potential nanodrugs will work by very specific and well-understood mechanisms ; one of the major impacts of nanotechnology and nanoscience will be in leading development of completely new drugs with more useful behavior and less side effects.

As a musical style psychedelic rock attempted to replicate the effects and enhance the mind-altering experiences of hallucinogenic drugs, incorporating new electronic and record effects, extended solo's and improvisation and was particularly influenced by eastern mysticism, reflected in use of exotic instrumentation, particularly from Indian music or the incorporation of elements of eastern music.

Application of genomic technologies to new drug discovery and further characterization of older drugs.

The vast majority of these drugs are benzimidazole derivatives ; however, promising new research indicates that imidazopyridine derivatives may be a more effective means of treatment.

His new poem, a love poem, told of a young husband leading his wife upstairs to the bedroom when the lights in the house have failed.

Willard Thorp, in his new book, American Writing In The Twentieth Century, observes, quite validly it seems: `` Certain subjects are conspicuously absent or have been only lightly touched.

Avant-garde choreographers, seeking new forms of continuity for their new vocabulary of movements, have turned to similar approaches.

The new fact the initiates of this cult have to learn is that they must move toward simplicity.

The ingredients of Faulkner's novels and stories are by no means new with him, and most of the problems he takes up have had the attention of authors before him.

But, just as we drew on Europe for assistance in our earlier years, so now do these new and emerging nations that do have this faith and determination deserve help.

Fifth, we have just completed a year's experience with our new space law.

We must, therefore, have a look at the new archaeological material and re-examine the literary and place-name evidence which bears upon the problem.

With destructive tensions and pressures removed men have the vigor and energy to construct a new human life -- rebuilding entire cities, expanding facilities for entertainment, providing unlimited opportunities for education -- indeed, for the first time giving everyone the chance to employ his talents to the fullest.

Since the great flood of these dystopias has appeared only in the last twelve years, it seems fairly reasonable to assume that the chief impetus was the 1949 publication of Nineteen Eighty-Four, an assumption which is supported by the frequent echoes of such details as Room 101, along with education by conditioning from Brave New World, a book to which science-fiction writers may well have returned with new interest after reading the more powerful Orwell dystopia.

The recent experiments in the new poetry-and-jazz movement seen by some as part of the `` San Francisco Renaissance '' have been as popular as they are notorious.

Lawrence Ferlenghetti and Bruce Lippincott have concentrated on writing a new poetry for reading with jazz that is very closely related to both the musical forms of jazz, and the vocabulary of the musician.

However, his subject matter and basic themes have remained surprisingly consistent, and these, together with certain key poetic images, may be traced through all his work, including the new jazz experiments.

The immense amount of interest that the new jazz had for the younger generation must have impressed him, and he began working toward the merger of jazz and poetry, as he had previously attempted the union of graphic art and poetry.

These new poems have only a few direct references to jazz and jazz musicians, but they show changes in Patchen's approach to his poetry, for he has tried to enter into and understand the emotional attitude of the jazz musician.

Even though headquarters actually have been moved into the Chatham building, do they believe that they can make the new name stick??

Economy class fares and charter flights have attracted almost all new passengers to the airlines.

Communist guerrillas recently have been reported increasing their activities and the great flood of the Mekong River has interposed a new crisis.

On net balance, in spite of Controller Gerosa's opposition to the new Charter as an invasion of his office, the Controller will have the opportunity for greater usefulness to good government than he has now.

As the mother of an autistic child who is lacking in interest and enthusiasm about almost anything, I have to manipulate my son's fingers for him when he first plays with a new toy.

Time, of course will testify whether the new version will have achieved its purpose.

In the second and third chapters of Revelation the new version retains, however, the old phrase `` angel of the church '' which Biblical scholars have previously interpreted as meaning bishop.

So the Commission's announcements of the new Soviet shots have been confined to one or two bleak sentences, with the fission yield usually left vague.

`` Tomorrow will be a new experience -- I have never before made love to a nightingale.