Azapirones are poorly but nonetheless appreciably absorbed and have a rapid onset of action, but have only very short half-lives ranging from 1 – 3 hours.

Azapirones are a class of drugs used as anxiolytics and antipsychotics.

Azapirones are a class of 5-HT < sub > 1A </ sub > receptor agonists.

We'll still have the rifle, and I might be able to round up some more.

with more time I could have loosened a small burr or cotter pin --

But in our case -- and neither my wife nor I have extreme views on integration, nor are we given to emotional outbursts -- the situation has ruined one or two valued friendships and come close to wrecking several more.

Only one rule prevailed in my conversations with these men: The more highly placed they are -- that is, the more they know -- the more concerned they have become.

Out of water, brick, and tile they have made far more than just a bridge.

And Hamilton, who felt it `` a religious duty '' to oppose Aaron Burr's political ambitions, would have been a better actuarial risk had he shown more literary restraint.

Some painters have less interest in the experience of the moment, with its attendant urgencies and ambiguities, than in looking beyond the flux of particular impressions to a higher, more serene level of truth.

Social invention did not have to await social theory any more than use of the warmth of a fire had to await Lavoisier or the buoyant protection of a boat the formulations of Archimedes.

This and other fears of the solar system have disappeared gradually, first, with the Ptolemaic system and its built-in concept of periodicity and then, more firmly, with the Newtonian innovation of an universal force that could account quantitatively for both terrestial and celestial motions.

I believe that what I do has some effect on his actions and I have learned, in a way, to commune with drunks, but certainly my actions seem to resemble more nearly the performance of a rain dance than the carrying out of an experiment in physics.

The major effect of these advances appears to lie in the part they have played in the industrial revolution and in the tools which scientific understanding has given us to build and manipulate a more protective environment.

In fact, the recent warnings about the use of X-rays have introduced fears and ambiguities of action which now require more detailed understanding, and thus in this instance, science has momentarily aggravated our fears.

I have more than once sat cross-legged in the grass through a long summer morning and watched without touching while a poppy bud higher than my head slowly but visibly pushed off its cap, unfolded, and shook out like a banner in the sun its flaming vermilion petals.

Another, more interesting explanation, is hinted at by Watson when he observes on several occasions that Holmes would have made a magnificent criminal.

Ironically no president we have had would have regretted more than President Eisenhower the possibility to which his own words, in the press conference held at the beginning of August, testified: that unable as he was himself to say his running was best for the country, unconsciously he had placed his party before his nation.

This means that the inception of change itself can begin only when the factors conducive to change have already become more powerful than those anchoring the existent form in being.

What is more, the legends have become so sacrosanct that the very habit of self-examination or self-criticism smells of low treason, and men who practice it are defeatists and unpatriotic scoundrels.

If you cut down these horrible buildings you'll have no more traffic jams.

I do not suppose you ever heard of F. Scott Fitzgerald, living or dead, and moreover I do not suppose that, even if you had, his legend would have seemed to you to warrant more than a cluck of disapproval.

Whether you experienced the passion of desire I have, of course, no way of knowing, nor indeed have I wished with even the most fleeting fragment of a wish to know, for the fact that one constitutes by one's mere existence so to speak the proof of some sort of passion makes any speculation upon this part of one's parents' experience more immodest, more scandalizing, more deeply unwelcome than an obscenity from a stranger.

Chewing it over with his colleagues and in his own mind, he reaches a tentative identification of the question -- tentative because it may change as he explores it further and because, if no tolerable answer can be found, it may have to be changed into one which can be answered.

Because of its " graphic " nature, this tale has at times been translated incompletely, as in John Payne's translation, where Alibech's sexual awakening is left untranslated and is accompanied with this footnote: " The translators regret that the disuse into which magic has fallen, makes it impossible to render the technicalities of that mysterious art into tolerable English ; they have therefore found it necessary to insert several passages in the original Italian.

He added: " We are in some danger of resting our position too exclusively upon the existence, the nature and the wishes of the inhabitants of the Falkland Islands ... if the population of the Falkland Islands did not desire to be British, the principle that the Queen wishes no unwilling subjects would long ago have prevailed ; but we should create great difficulties for ourselves in other contexts, as well as in this context, if we rested our action purely and exclusively on the notion of restoring tolerable, acceptable conditions and self-determination to our fellow Britons on the Falkland Islands ....

For instance, a typical computer CPU will have a purpose-made fan to ensure its operating temperature is kept within tolerable limits.

Petruchio's treatment of Katherina may well have the effect of making the domination of one's wife seem tolerable, as long as physical force is not used.

For the user to have any hope of reconstructing with a maximum distortion D, we must impose the requirement that the information lost in transmission does not exceed the maximum tolerable loss of H − R ( D ) bits / symbol.

When asked how much it would cost to keep a single man in clothes, he was supposed to have replied: " Why, with tolerable economy, I think it might be done with £ 800.

This chaotic situation was tolerable on completely horse-drawn traffic wagonways, but with faster steam trains it soon became unworkable, as the faster speeds meant a collision could have serious consequences.

A once-common schoolboy doggerel, which though very poor Latin, would have done a tolerable job of reinforcing the rhythms of Latin hexameters:

Yet austerity did have its advantages – living standards were preserved at tolerable levels, while the resources saved were made available to feed and clothe and shelter the entire population adequately, while at the same time integrating and resettling over 800, 000 Jewish refugees from Arab countries after their forced expulsions.

Leagues did not desire to end the vocal support of fans, but learned that they would have to regulate artificial noise made by electronics, horns, bells, and the like, to make game play tolerable.

This family has achieved a tolerable modus vivendi by ignoring the skeletons ( among the secrets: Gregers ' father may have impregnated his servant Gina then married her off to Hjalmar to legitimize the child, and Hjalmar's father has been disgraced and imprisoned for a crime the elder Werle committed.

Whilst this may have offered a tolerable living during the boom years of the Napoleonic wars, when labour had been in short supply and corn prices high, the return of peace in 1815 brought with it plummeting grain prices and an oversupply of labour.

May it please the Honourable Bench to indulge me a few Words: I am a poor unhappy Woman ; who have no Money to Fee Lawyers to plead for me, being hard put to it to get a tolerable Living.

Two days later, President Lincoln, still acting as Commander-in-Chief, directed Flag Officer Goldsborough: " If you have tolerable confidence that you can successfully contend with the Merrimac and the North used the ships ' former name without the help of the Galena and two accompanying gunboats, send the Galena and two gunboats up the James River at once to support General McClellan.

* none of the packages marked have a negative error greater than twice the tolerable negative error ( since no such package may bear the estimated sign ).

The tolerable pH ranges have been found to be approximately 3. 9 to 9. 5.

Scholars think it likely that this development was founded by the Roman garrison of the nearby Antonia Fortress, who would also have been able to protect it from attack the location of the asclepieion, outside the then city walls, would have made its presence tolerable to the Jews, who might otherwise have objected to a non-Jewish religious presence in their holy city.

They also found that MAOIs have a slight advantage over the use of other medication in treating this disorder Though, the author of this study cautions that MAOIs should not necessarily be the first line of defense in the treatment of dysthymia, as they are often less tolerable than their counterparts, such as SSRIs

The ultimate conclusion is that one can have a tolerable life not by complete elimination of desire, since this would lead to boredom, but by becoming a detached observer of one's own will and being constantly aware that most of one's desires will remain unfulfilled.

" She also states that before no-fault divorce was legalized, " Expensive litigation strained court resources " and that " once you permit the courts to determine when a person ’ s desire to leave is legitimate, you open the way to arbitrary decisions about what is or should be tolerable in a relationship, made by people who have no stake in the actual lives being lived.

They are called carrot diagrams, because they have an elongated triangle in the centre, which looks like a carrot, and indicates the high ( normally unacceptable ) risks at the top and the low ( broadly tolerable ) risks at the bottom.