Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite serious domestic turmoil, the patriotism engendered by Morocco ’ s participation in the Middle East conflict and by the events in Western Sahara contributed to Hassan ’ s popularity and strengthened his hand politically.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

" Despite a serious preservation effort, The Museum of Arts & Design radically altered the building, which reopened in 2008.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite serious initial problems with the Austrian censors who had control over northern Italian theatres at the time, the opera had a triumphant premiere and is considered by many to be the first of the operatic masterpieces of Verdi's middle-to-late career.

Despite the apparent risk, the statistical incidence of injury in supervised training and competition is extremely low.

Despite a rotator cuff injury during the 1985 season, Smith posted career highs in multiple offensive categories in 1987.

Despite his injury problems, McNair finished the season as the second leading rusher on the team with 337 yards and scoring 8 touchdowns.

Despite his injury problems in 1891, few doubted that Grace should captain England in Australia the following winter when he led Lord Sheffield's team to Australia in 1891 – 92.

Despite injury, Davenport reached the US Open quarterfinals, where she again lost to Henin.

Despite these views, some surgeons have suggested that in their own hands endoscopic carpal tunnel release has been associated with a higher incidence of median nerve injury, and for this reason it has been abandoned at several centers in the United States.

Despite finishing the 2005 – 06 season in seventh, Roeder's fortunes changed in the 2006 – 07 season, with a terrible injury run to the senior squad, and he left the club by mutual consent on 6 May 2007.

Despite still not having Hill due to injury, the Magic entered the playoffs for the third straight year.

Despite four 50-win seasons, the Bulls began to fall apart after an injury to Sloan and the retirement of Walker.

Despite the disappointment, Williams proved to be one of the elite point guards in the league, averaging 19. 4 points and 10. 8 assists per game, second in the league, despite playing the entire season with a lingering ankle injury.

Despite the injury, he continued to perform the entire show with a broken wrist, before heading to the emergency room.

Despite spending some three months of the season out with a muscle injury, the 1952 – 53 campaign proved Smith's words to be accurate, as a 38 year old Matthews won an FA Cup winners medal in a match which was, despite Mortensen's hat-trick, subsequently dubbed the ' Matthews Final '.

Despite his head injury, Cochrane served in the United States Navy during World War II as did Bill Dickey of the Yankees, giving the Navy the two greatest catchers baseball had yet seen ; with Yogi Berra also serving but not yet having reached the major leagues, there were actually three possible " greatest catchers ever " in the WWII-era Navy.

Despite being ranked within the world's top 16, Krajicek just missed out on the seedings for the tournament, but when seventh seed ( and world number two ) Thomas Muster pulled out shortly before the tournament due to an injury, Krajicek was given Muster's place in the draw.

Despite her knee injury, she made it to the quarterfinals, where she lost to Tsvetana Pironkova.

Despite all precautions, accidents and errors occur from time to time, which may result in property damage, injury and in severe cases loss of life.

Despite the injury, he competed in RallyCross three days later using hand controls mounted to the steering wheel.

Despite the protection and safety regulations, the rattan still occasionally causes pain or injury, such as a blow landing where it wasn't intended, i. e. the underarm or other parts that are generally not or difficult to cover with armor.

Despite these safety precautions, the ski racing community is well aware of the inherent risks in Downhill skiing, for it is possible for racers to suffer serious injury or death while practicing or competing.

Despite his performances dipping as the result of a persistent groin injury and a reported training ground bust-up with teammate Zlatan Ibrahimović, Vieira helped Juventus retain the Scudetto, which was later stripped.

Despite missing several months of the 2005 season due to the injury, Els won the second event on his return, the Dunhill Championship.

Despite his injury, Leslie was appointed Field Marshal in 1636 and was one of the Swedish commanders at the Battle of Wittstock in the same year.

Despite the injury, Oates finished fourth in the NHL with 41 assists in a season disrupted by a work stoppage.