Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite a serious injury which ruled Shearer out for half the season, Dalglish achieved fourth position with the team in the first year of the new Premier League.

Despite serious domestic turmoil, the patriotism engendered by Morocco ’ s participation in the Middle East conflict and by the events in Western Sahara contributed to Hassan ’ s popularity and strengthened his hand politically.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite serious initial problems with the Austrian censors who had control over northern Italian theatres at the time, the opera had a triumphant premiere and is considered by many to be the first of the operatic masterpieces of Verdi's middle-to-late career.

Despite these benefits, carbon ink is not ideal for permanence and ease of preservation.

Despite these moves toward independence, economic realities seemed to work against secession from the Soviet Union In a referendum on the preservation of the USSR, in March 1991, 88. 7 % of the voters approved a proposal to remain part of the union as a " renewed federation.

Despite calls for their abolition, the New Zealand Law Commission recommended their preservation in a 2001 report titled Subsidising Litigation.

Despite these challenges, if the information retrieved does not appear to be sufficient, or a poor preservation is achieved, authors like J. A.

Despite their ubiquity, very few have survived into preservation as there is very little scope of operating them due to their unique means of obtaining power, slow speed and the fact they greatly exceed the loading gauge of most railway lines.

Despite this, the style is appreciated by others, with some of the angular features being softened and updated in buildings currently being constructed in Israel and Latin America, and preservation efforts are taking place in the United Kingdom.

Despite being officially protected for almost 150 years, it was only in 2007 that a preservation plans for the mountain were made.

Despite the considerable decline in the number of geisha in Gion in the last one hundred years, it is still famous for the preservation of forms of traditional architecture and entertainment.

Despite home entertainment and car ownership becoming almost ubiquitous, many of these activities to a greater or lesser degree continue in the town today thanks to preservation of the green spaces.

Despite the challenge, the enthusiasm with which the only recently financially autonomous Oneida have undertaken language preservation bodes well for their success.

Despite the location of Mission Control in Houston, Texas declined to grant similar status to the site as its historic preservation laws limit such designations to properties located within the state.

Despite the inherent disadvantages of joining a national religious minority, a deep concern for the preservation of their traditional ancestor religions made Hinduism a more palatable option than Islam for several ethnic groups in the outer islands.

Despite calls for its preservation by many locals, including some politicians, the stall was closed on July 30, 2005.

Despite the entire class being sold for scrapping, four have survived into preservation, having been rescued from the Woodham Brothers scrapyard in Barry, Vale of Glamorgan, South Wales.

Despite the Democratic majority in Congress, the effort to create a national health care system ultimately died when compromise legislation by George J. Mitchell failed to gain a majority of support in August 1994.

Despite his all-out effort to reduce the public-sector deficit, the overall ratio of fiscal deficit to the GDP in 1990 showed little change from that in 1989.

Despite his opposition to Operation Barbarossa and a preference for focusing the war effort against Britain, on 28 June 1941, Ribbentrop began a sustained effort to have Japan attack the Soviet Union without bothering to inform Hitler first.

Despite strenuous effort, she realised that there were still many unhappy beings yet to be saved.

Despite the name, it simply gives a player a chance of killing another player dependent on how much OOC currency that player put into the effort.

Despite his physicians ' predictions to the contrary, after great effort Baba managed to walk again, but from that point on he was in constant pain and was severely limited in his ability to move.

Despite some early success, the wolves were relocated to North Carolina in 1998, ending the effort to reintroduce the species to the Park.

Despite a valiant effort by McNeal, the 185 lb.

Despite their great defensive effort, the Giants still trailed 13-9 late in the fourth quarter, but a 30-yard run from linebacker Gary Reasons on a fake punt set up kicker Matt Bahr's fourth field goal, cutting their deficit to 13-12.

Despite a reversal in Buddhist influence which began under King Langdarma ( 836-842 ), the following centuries saw a colossal effort in collecting available Indian sources, many of which are now extant only in Tibetan translation.

Despite the departure of Stevie Nicks, Christine remained loyal to Mick Fleetwood and her former husband, recording five songs for the band's 1995 effort Time.

Despite the resulting poor production, the album was a well-received effort that was credited for blending elements of thrash and speed metal.

Despite being impacted by diversion of resources to jump start the Apple / IBM / Motorola effort, the POWER2 took five years from start to system shipment.

Despite Picard's effort to force her to do her duty, in the end, she betrays Starfleet and joins the rebel group.

Despite Miller's effort, the Pacers lost, sending Miller into retirement without an NBA Championship in his 18-year career, all with the Pacers.

Despite a two-goal effort ( one on a shorthanded breakaway ) from Linden ( who was playing with cracked ribs ), Vancouver lost the game by a 3 – 2 score.

Despite a valiant effort, the Tramp is thrashed.

Despite the hardships, the city made an effort to renovate the degraded area of St-Leu during this time.

Despite his effort, Australia lost and the West Indies took an unassailable lead of 2 – 0.

Despite years of effort and the occasional hoax ( i. e. cold fusion ), no man-made fusion reaction has produced more energy than it consumed and been a viable source of electricity.

Despite the apparent effort, the rules and regulations of the LAC were not fairly implemented.

Despite the UN Resolution, UNITA was able to continue to sell or barter some diamonds in order to finance its war effort.