Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite a serious injury which ruled Shearer out for half the season, Dalglish achieved fourth position with the team in the first year of the new Premier League.

Despite serious domestic turmoil, the patriotism engendered by Morocco ’ s participation in the Middle East conflict and by the events in Western Sahara contributed to Hassan ’ s popularity and strengthened his hand politically.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

" Despite a serious preservation effort, The Museum of Arts & Design radically altered the building, which reopened in 2008.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite his initial reluctance, Johnson agreed to run for re-election for governor in 1855, and became the nominee at the party convention.

Despite initial success, Shapur lifted his siege after his army missed an opportunity to exploit a collapsed wall.

Despite initial activity in the Lords, his career there was cut short by the House of Lords Act 1999.

Despite its initial recklessness, the alliance was very prestigious for both families.

Despite his initial high profile after the end of the Monkees, Jones struggled to establish himself as a solo artist.

Despite some initial success, bolstered by heavy advertising, the brand did not prove popular and was eventually withdrawn from sale.

Despite all this, the film is also one of the most widely seen Godzilla films in the United States — it was popular in its initial theatrical release, largely due to an aggressive marketing campaign, including elaborate posters of the two title monsters battling atop New York City's World Trade Center towers, presumably to capitalize on the hype surrounding the Dino De Laurentiis remake of King Kong, which used a similar image for its own poster.

Despite the initial popularity of the measure, the newspapers praised Cleveland's veto.

Despite initial successes, the German army was stopped close to Moscow in December 1941.

Despite some initial expressions of enthusiasm, Hoxha and Shehu mistrusted Nikita Khrushchev's programs of " peaceful coexistence " and " different roads to socialism " because they appeared to pose the threat that Yugoslavia might again try to take control of Albania.

Despite its initial dismal commercial showing, " Forever Changes " has since gained recognition as one of the all-time great rock albums.

Despite the initial distrust of the King and Crown Prince, and the loathing of Queen Augusta, Bismarck soon acquired a powerful hold over the King by force of personality and powers of persuasion.

Despite great initial excitement, the seed was found to be that of a European Juncaceae or Rush plant that had been glued into the fragment and camouflaged using coal dust.

Despite the initial success, the Olympic Movement faced hard times, as the 1900 ( in De Coubertin's own Paris ) and 1904 Games were both swallowed by World's Fairs, and received little attention.

Despite initial media reports, the affidavit made no mention of Clemens or Pettitte.

Despite the marginalised Left Opposition's demand for the restoration of Soviet democracy, Stalin developed a bureaucratic, authoritarian government, that was condemned by democratic socialists, anarchists and Trotskyists for undermining the initial socialist ideals of the Bolshevik Russian Revolution.

Despite a period of instability known as the Battle of the Booksellers when the initial copyright terms under the Statute began to expire, the Statute of Anne remained in force until the Copyright Act 1842 repealed it.

Despite an initial period of compliance, the principle of donating copies of books to certain libraries lapsed, partly due to the unwieldiness of the statute's provisions and partly because of a lack of cooperation by the publishers.

Despite initial opposition from her parents and difficulties presented by a sexist society, she gained education from books in her father's library and from correspondence with famous mathematicians such as Lagrange, Legendre, and Gauss.

Despite an initial reluctance to develop for video game consoles, Square entered the Nintendo Famicom market in December 1985 with the porting of Thexder.

Despite initial excitement, the guidance of longtime baseball executives, Eddie Leishman and Buzzie Bavasi as well as a new playing field, the team struggled ; the Padres finished in last place in each of its first six seasons in the NL West, losing 100 games or more four times.

Despite initial setbacks, he won increasing support among the natives.

Despite its initial focus on the elites, the Union was successful in raising funds from across French society.

Despite their initial cooperation against " revisionism ," Hoxha denounced Mao as a revisionist, along with almost every other self-identified Communist organization in the world.

Despite the initial failure of the story, it changed the course of Clarke's career.