Such modifications can also determine the localization of the protein, e. g., the addition of long hydrophobic groups can cause a protein to bind to a phospholipid membrane.

Abzymes are usually artificial constructs, but are also found in normal humans ( anti-vasoactive intestinal peptide autoantibodies ) and in patients with autoimmune diseases such as systemic lupus erythematosus, where they can bind to and hydrolyze DNA.

The abzyme does more than bind to the site, it actually destroys the site, rendering HIV inert, and then can attach to other viruses.

T cells cannot bind native antigens, but require that they be processed by APCs, whereas B cells can be activated by native ones.

Each of these variants can bind to a different target, known as an antigen.

For example the M-T2 protein of myxoma viruses can bind TNF preventing it from binding the TNF receptor and inducing a response.

Furthermore, many viruses express p53 inhibitors that can bind p53 and inhibit its transcriptional transactivation activity.

Adenine binds with thymine and uracil ; Thymine binds only with adenine ; and cytosine and guanine can bind only with each other.

Calcitonin is produced by parafollicular cells in the thyroid gland, and can bind to receptors on osteoclasts to directly inhibit osteoclast activity.

They can aid the dispersion of the catalytic material or bind to reagents.

In the most general sense of the word, a cement is a binder, a substance that sets and hardens independently, and can bind other materials together.

If " overseer " enzymes note that residues are misfolded, proteins within the RER will re-add glucose residues so that other Calreticulin / Calnexin can bind to these proteins and prevent them from proceeding to the Golgi.

As a result, proteins like transcription factors that can bind to specific sequences in double-stranded DNA usually make contacts to the sides of the bases exposed in the major groove.

For example, enzymes lose their activity, because the substrates can no longer bind to the active site, and because amino acid residues involved in stabilizing substrates ' transition states are no longer positioned to be able to do so.

Mammalian steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestagens.

* Add two for every lone pair bonding to the metal ( e. g. each phosphine ligand can bind with a lone pair ).

GTPases ( singular GTPase ) are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate ( GTP ).

The mammalian hemoglobin molecule can bind ( carry ) up to four oxygen molecules.

Each heme group contains one iron atom, that can bind one oxygen molecule through ion-induced dipole forces.

A sixth position can reversibly bind oxygen by a coordinate covalent bond, completing the octahedral group of six ligands.

Conversely, a high pH, low CO < sub > 2 </ sub >, or low 2, 3 BPG favors the relaxed form which can better bind oxygen.

Hemoglobin can bind protons and carbon dioxide, which causes a conformational change in the protein and facilitates the release of oxygen.

Hemoglobin deficiency can be caused either by decreased amount of hemoglobin molecules, as in anemia, or by decreased ability of each molecule to bind oxygen at the same partial pressure of oxygen.

Compounds that bind to isolated recombinant proteins are one thing ; chemical tools that can perturb cell function another ; and pharmacological agents that can be tolerated by a live organism and perturb its systems are yet another.

I don't know what makes you think you can get away with this kind of business, and I don't care about that, either.

`` The road's washed badly '', said Dill, `` but there's a trail you can get over with a horse.

Besides, 'tain't no more'n right for me to follow with my black oxen, so's I can unhook and pull up fast if either of you get in a pinch ''.

It'll probably be at least an hour or two before I can check back with you.

It is nothing you can put your fingers on but the air suddenly fills with a high charge of electricity.

It is Eromonga -- look hard, you can see with your naked eye the wooden scaffolding on the cliff ''.

All can be connected with the gold circuit from their homes.

His consoles can give him instant contact with more than seventy bases around the world and with every SAC aircraft.

It is well then that in this hour both of `` national peril '' and of `` national opportunity '' we can take counsel with the men who made the nation.

His first inaugural address speaks of `` my country whose voice I can never hear but with veneration and love ''.

Instead of giving themselves spontaneously to the orgiastic release that jazz can give them, they undergo psychoanalysis or flirt with mysticism or turn to prostitutes for satisfaction.

What they discuss with dialectical seriousness is the degree to which sex can inspire the Muse.

When words can be used in a more fresh and primitive way so that they strike with the force of sights and sounds, when tones of sound and colors of paint and the carven shape all strike the sensibilities with an undeniable force of data in and of themselves, compelling the observer into an attitude of attention, all this imitates the way experience itself in its deepest character strikes upon the door of consciousness and clamors for entrance.

One can meet with aloofness almost anywhere: the THIDIU viewpoint, It Doesn't Affect Us!!

You've already sent your daughter to Miss X's select academy for girls and your son to Mr. Y's select academy for boys, and you can be as liberal as you please with strict impunity.

This is an unsolved problem which probably has never been seriously investigated, although one frequently hears the comment that we have insufficient specialists of the kind who can compete with the Germans or Swiss, for example, in precision machinery and mathematics, or the Finns in geochemistry.

And I select this sentence as its pertinent summation: `` in essence the drama of his ( Eisenhower's ) Presidency can be described as the ordeal of a nation turned conservative and struggling -- thus far with but limited and precarious success -- to give effective voice and force to that conservatism ''.

One of the obvious conclusions we can make on the basis of the last election, I suppose, is that we, the majority, were dissatisfied with Eisenhower conservatism.

Here there may be an analogy with cancer: we can detect cancers by their rapidly accelerating growth, determinable only when related to the more normal rate of healthy growth.

Hence the prime issue, as I see it, is whether a democratic or free society can master technology for the benefit of mankind, or whether technology will rule and develop its own society compatible with its own needs as a force of nature.

So we are faced with a vast network of amorphous entities perpetuating themselves in whatever manner they can, without regard to the needs of society, controlling society and forcing upon it a regime representing only the corporation's needs for survival.

Proprietorships can establish a meaningful identity, representing a human personality, and thus establish sincere relationships with customers and community.

But is the result new barnsful of tested knowledge on the basis of which we can with confidence solve our domestic and international problems??