This domain may be involved in regulating the activity of JH1, and was likely a duplication of the JH1 domain which has undergone mutation post-duplication.

* A decrease renal protein kinase C is caused.

CheA in turn transfers phosphoryl groups to conserved aspartate residues in the response regulators CheB and CheY CheA is a histidine kinase and it does not actively transfer the phosphoryl group.

BI811283 is a small molecule inhibitor of the Aurora B kinase protein being developed by Boehringer Ingelheim for use as an anti-cancer agent.

Another use of gene therapy is the introduction of enzymes into these cells that make them susceptible to particular chemotherapy agents ; studies with introducing thymidine kinase in gliomas, making them susceptible to aciclovir, are in their experimental stage.

The phosphorylation of molecules requires that ATP is imported into the lumen of the Golgi and utilised by resident kinases such as casein kinase 1 and casein kinase 2.

In hyperthyroidism CK-MB ( Creatine kinase ) is usually elevated.

Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase — meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines.

Janus kinase ( JAK ) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway.

JH2 is a " pseudokinase domain ", a domain structurally similar to a tyrosine kinase and essential for a normal kinase activity, yet lacks enzymatic activity.

The amino terminal ( NH < sub > 2 </ sub >) end ( JH4-JH7 ) of Jaks is called a FERM domain ( short for band 4. 1 ezrin, radixin and moesin ); this domain is also found in the focal adhesion kinase ( FAK ) family and is involved in association of JAKs with cytokine receptors and / or other kinases.

These include sphingosine-1-phosphate, a sphingolipid derived from ceramide that is a potent messenger molecule involved in regulating calcium mobilization, cell growth, and apoptosis ; diacylglycerol ( DAG ) and the phosphatidylinositol phosphates ( PIPs ), involved in calcium-mediated activation of protein kinase C ; the prostaglandins, which are one type of fatty-acid derived eicosanoid involved in inflammation and immunity ; the steroid hormones such as estrogen, testosterone and cortisol, which modulate a host of functions such as reproduction, metabolism and blood pressure ; and the oxysterols such as 25-hydroxy-cholesterol that are liver X receptor agonists.

This protein is an autonomously active form of the enzyme protein kinase C ( PKC ), known as PKMζ.

A second category of gravis is due to autoantibodies against the MuSK protein ( muscle specific kinase ), a tyrosine kinase receptor which is required for the formation of the neuromuscular junction.

Bcr-Abl codes for a receptor tyrosine kinase, which is constitutively active, leading to uncontrolled cell proliferation.

Gankyrin, a recently identified oncoprotein, is one of the 19S subcomponents that also tightly binds the cyclin-dependent kinase CDK4 and plays a key role in recognizing ubiquitinated p53, via its affinity for the ubiquitin ligase MDM2.

The mechanism for this effect is not clear, but is hypothesized to be specific to cells in quiescent states, or to result from the differential activity of the pro-apoptotic kinase JNK.

His sailing vessel is guided by fate to the shores of his own country at a time when Sibylla's domain is overrun by the armies of one of her rejected suitors.

In this domain the simple fact of coexistence in the same local, national, and world community is enough to guarantee that we cannot refrain from having some effect, large or small, upon Gentile-Jewish relations.

The difference is important, for although the older law of nations did cover relationships among sovereigns, this was by no means its exclusive domain.

Its domain is the powerset of A ( with the empty set removed ), and so makes sense for any set A, whereas with the definition used elsewhere in this article, the domain of a choice function on a collection of sets is that collection, and so only makes sense for sets of sets.

This exon encodes a portion of the mature TNF domain, as well as the leader sequence which is a highly conserved region necessary for proper intracellular processing.

The protein is organized with 6 transmembrane segments, then the C1 cytoplasmic domain, then another 6 membrane segments, and then a second cytoplasmic domain called C2.

In Mycobacterium tuberculosis, the AC-III polypeptide is only half as long, comprising one 6-transmembrane domain followed by a cytoplasmic domain, but two of these form a functional homodimer that resembles the mammalian architecture.

Abbadie gave his domain the name Abbadia, which is the name still used in Basque.

The castle was classified as a protected historical monument by France in 1984 and most of the domain now belongs to the Coastal Protection Agency and is managed by the city of Hendaye.

It is often used in signal processing for analyzing functions or series of values, such as time domain signals.

Active Directory ( AD ) is a directory service created by Microsoft for Windows domain networks.

For example, when a user logs into a computer that is part of a Windows domain, Active Directory checks the submitted password and determines whether the user is a system administrator or normal user.

A tree is a collection of one or more domains and domain trees in a contiguous namespace, linked in a transitive trust hierarchy.

If the domain of F is a disjoint union of two or more intervals, then a different constant of integration may be chosen for each of the intervals.

A binary relation is the special case of an n-ary relation R ⊆ A < sub > 1 </ sub > × … × A < sub > n </ sub >, that is, a set of n-tuples where the jth component of each n-tuple is taken from the jth domain A < sub > j </ sub > of the relation.

The sets X and Y are called the domain ( or the set of departure ) and codomain ( or the set of destination ), respectively, of the relation, and G is called its graph.

In fact, one important aspect of their very religion is the annihilation of men ''.

but for this discussion the most important division is between those who have been reconstructed and those who haven't.

But more important, and the thing which the casual traveler and the blind sojourner often do not see, is that these places and activities are often the settings in which Persians exercise their extraordinary aesthetic sensibilities.

The `` approximate '' is important, because even after the order of the work has been established by the chance method, the result is not inviolable.

A broader concept of imitation is needed, one which acknowledges that true invention is important, that the artist's creativity in part transcends the non-artistic causal factors out of which it arises.

But Aristotle kept the principle of levels and even augmented it by describing in the Poetics what kinds of character and action must be imitated if the play is to be a vehicle of serious and important human truths.

Let me quote him even more fully, for his analysis is important to my theme.

However, it is important to trace the philosophy of the French Revolution to its sources to understand the common democratic origin of individualism and socialism and the influence of the latter on the former.

This is important to understanding the position that doctrinaire liberals found themselves in after World War 2, and our great democratic victory that brought no peace.

But in looking at Faulkner against his background in Mississippi and the South, it is important not to lose the broader perspective.

It may be that in this comment he has broken from the conventional pattern more violently than in any other regard, for the treatment in his books is far removed from even the genial irony of Ellen Glasgow, who was the only important novelist before him to challenge the conventional picture of planter society.

All we want from Dr. Huxley's statement is the feeling that this is an open world, in the view of the best scientific opinion, with practically no directional commitments as to what may happen next, and no important confinements with respect to what may be possible.

However, it was not of innocence in general that I was speaking, but of perhaps the frailest and surely the least important side of it which is innocence in romantic love.

An advantage of being exposed to such specificity about an important and recurring feature of social reality is that it can be taken advantage of by the reader to examine covert as well as overt resonances within himself, resonances triggered by explicit symbols clustering around the central figure of the Jew.

Clearly what the person brings to the reading is important.

Probably the most important thing to focus on is not the development of conscience, which may well be almost beyond the reach of literature, but the contents of conscience, the code which is imparted to the developed or immature conscience available.

Here an important caveat is in order.

It is most important that we recognize the law of love as being unbreakable in all personal relationships, whether individually, socially or as between whole nations of people.

This truth that the moral law is natural has other important corollaries.

What is not so well known, however, and what is quite important for understanding the issues of this early quarrel, is the kind of attack on literature that Sidney was answering.