Mutations leading to the loss of function of a gene are much more common than mutations that produce a new, fully functional gene.

Mutations in TERT have been implicated in predisposing patients to aplastic anemia, a disorder in which the bone marrow fails to produce blood cells, in 2005.

Mutations that only mildly decrease the enzyme's function do not normally cause the severe form of LNS, but do produce a milder form of the disease which still features purine overproduction accompanied by susceptibility to gout and uric acid nephrolithiasis.

Mutations that cause the altered codon to produce an amino acid with similar functionality ( i. e. a mutation producing leucine instead of isoleucine ) are often also classified as silent ; if the properties of the amino acid are conserved, this mutation does not usually significantly affect protein function.

Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ < sub > 42 </ sub >, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ < sub > 40 </ sub >.

Mutations are changes in the DNA sequence of a cell's genome and are caused by radiation, viruses, transposons and mutagenic chemicals, as well as errors that occur during meiosis or DNA replication.

Mutations are caused by radiation, viruses, transposons and mutagenic chemicals, as well as errors that occur during meiosis or DNA replication.

Mutations in viral genes weakened their infectious ability, sometimes creating viruses that were able to infect and grow within only certain varieties of E coli.

Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals, or viruses, or can occur deliberately under cellular control during the processes such as meiosis or hypermutation.

Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit / hyperactivity disorder, schizophrenia, and the personality trait of novelty seeking.

* IARC TP53 Somatic Mutations database maintained at IARC, Lyon, by Magali Olivier

Koolhaas's next landmark publications were a product of his position as professor at Harvard University, in the design school's " Project on the City "; firstly the 720-page Mutations, followed by The Harvard Design School Guide to Shopping ( 2002 ) and The Great Leap Forward ( 2002 ).

Suddenly, evolutionary theorists could answer the charge that spontaneous random mutations should result overwhelmingly in deleterious changes to a fragile, monolithic genome: Mutations in homeobox regulation could safely — yet dramatically — alter morphology at a high level, without damaging coding for specific organs or tissues.

Mutations usually sound at pitches in the harmonic series of the fundamental and, except where they are derived from unit ranks, are always tuned pure.

Mutations in some homeotic genes can often be lethal and the cycle of life will end at embryogenesis.

COUM's earliest public events were impromptu musical gigs performed at various pubs around Hull ; titles for these events included Thee Fabulous Mutations, Space Between the Violins, Dead Violins and Degradation and Clockwork Hot Spoiled Acid Test.

* Beck's " High Five ( Rock the Catskills )" on the album Odelay ( 1996 ), starting at 2: 10 and finishing at 2: 30 ; and on " Tropicalia " from the album Mutations ( 1998 ) played by Smokey Hormel

Mutations in the Notch 3 gene ( on the short arm of chromosome 19 ) cause an abnormal accumulation of Notch 3 at the cytoplasmic membrane of vascular smooth-muscle cells both in cerebral and extracerebral vessels, seen as granular osmiophilic deposits on electron microscopy.

Mutations in the fukutin gene, located at human chromosome 9q31, are the cause of FCMD.

Mutations at many steps in the pathway towards the restriction point can result in cancerous growth of cells.

He wrote seven songs with the band-" Ill in the Head " and " Forward to Death ", both of which appear on the band's debut album Fresh Fruit for Rotting Vegetables ; " Short Songs ", " Gaslight ", and " Straight A's ", which appear on the live album Live at the Deaf Club ; " Mutations of Today ", which appears on The 1978 Demos ; and " Religious Vomit ", which appears on the EP In God We Trust, Inc ..

Mutations in these photo receptors and their signal transduction components lead to seedling development that is at odds with light conditions, for example seedlings that show photomorphogenesis when grown in the dark.

Mutations that affect insulin-like signaling in worms, flies, and the growth hormone / IGF1 axis in mice are associated with extended lifespan.

The National Gerbil Society .< http :// www. gerbils. pwp. blueyonder. co. uk / gerbils / genetics. htm # Mutations ></ ref >

Mutations / knockout of other genes affecting the GH / IGF1 axis, such as Lit, Ghr and Irs1 have also shown extension in lifespan, but much more modest both in relative and absolute terms.

Mutations in this gene and / or its regulatory regions cause or hypohaptoglobinemia.

Mutations of the genes VHL, RET, NF1 ( Gene 17 Neurofibromatosis type 1 ), SDHB and SDHD are all known to cause familial pheochromocytoma / extra-adrenal paraganglioma.

Mutations in the Ras / mitogen activated protein kinase signaling pathways are known to be responsible for ~ 70 % of NS cases.

Mutations in this region can affect rate of efficiency of gene transcription, which in turn can alter levels of mRNA and, thus, protein levels in general.

Mutations in this region can affect the efficiency of gene transcription, which controls both the levels of mRNA and overall protein levels .< ref > name

Mutations in the coding region of GFAP have been shown to contribute to the accumulation of Rosenthal fibers.

Mutations in critical regions of Amyloid Precursor Protein, including the region that generates amyloid beta ( Aβ ), cause familial susceptibility to Alzheimer's disease.

Mutations and natural selection result in a species acquiring new traits and eventually evolving into one or more new species.

game as well as adding sophisticated new rule systems specific to the setting ( e. g. Mutations and ' Weird Science ').

Mutations in the gene for the prion protein can cause a misfolding of the dominantly alpha helical regions into beta pleated sheets.

Mutations of the corresponding gene in mice ( FOXP2 is fairly well conserved ; modern humans share the same allele as Neanderthals ) cause reductions in size and vocalization rate.

Mutations in several genes have been linked to several types of epilepsy.

One deck represents random Alpha Mutations, which can be drawn to gain temporary powers, and the other contains various Omega Tech, powerful technological devices that could possibly backfire on those that use them.

Mutations in two regulatory genes of white grapes turn off production of anthocyanins which are responsible for the color of purple grapes.

Mutations in the genes for the hemoglobin protein in a species result in hemoglobin variants.

Mutations of the thyroid-stimulating hormone receptor that cause a constitutive activation of the thyroid gland cells have been discovered recently.

Mutations in the gene HR can lead to complete hair loss, though this is not typical in humans.

Mutations can have an impact on the phenotype of an organism, especially if they occur within the protein coding sequence of a gene.

Mutations can involve large sections of DNA becoming duplicated, usually through genetic recombination.

Mutations can involve large sections of DNA becoming duplicated, usually through genetic recombination.

Mutations in such microRNAs ( known as oncomirs ) can lead to activation of oncogenes.

Mutations that deactivate p53 in cancer usually occur in the DBD.

Mutations in transpeptidases that lead to reduced interactions with an antibiotic are a significant source of emerging antibiotic resistance.

Mutations du surréalisme de l ' exil américain à l ' écart absolu ( 1941 – 1965 ), Les presses du réel, Dijon, 2007.

Mutations of the Chardonnay grape include the rare pink-berried " Chardonnay Rose "; also " Chardonnay Blanc Musqué ", which produces an intensely aromatic wine.

Mutations in genes can cause also affect skin colour through oculocutaneous albinism ( OCA ) – a lack of pigment in the eyes, skin and sometimes hair that occurs occasionally in a very small fraction of the population.

Mutations of this very polymorphic gene, such as Arg151Sys ( rs1805007 ), Arg160Trp ( rs1805008 ), Asp294Sys ( rs1805009 ), Val60Leu ( rs1805005 ) and Val92Met ( rs2228479 ) have been shown to cause red hair and pale skin that does not tan in a small percentage of the human population.

Mutations are an important force driving evolution.