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Once inside the cell, they bind to and activate estrogen receptors which in turn modulate the expression of many genes.
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Once and inside
Once the door was open, they crowded him inside the dark building.
Once inside the luxuriosly-upholstered landau, she drew the curtains and proceeded to give the startled youth the kind of physical examination usually reserved for army inductees.
Once inside, keep your eyes open ''!!
Once inside his apartment, he poured a drink with trembling hands and flopped limply in a chair.
Once inside the fortification, Alfred realised, the Danes enjoyed the advantage, better situated to outlast their opponents or crush them with a counter attack as the provisions and stamina of the besieging forces waned.
Once inside, they pressurized the LM cabin, went through a half-hour briefing with scientists in mission control, and configured the cabin for the sleep period.
Once the tip penetrates the animal the upper sub head broke off from the rest of the shaft, however, since it was still connected with the braided loop it rotated the head into a horizontal position inside the animal ’ s body so that it could not get away from the hunter.
Once inside the host, the trypomastigotes invade cells, where they differentiate into intracellular amastigotes.
Once inside the cell, the disulfide bond is reduced, and the A1 subunit is freed to bind with a human partner protein called ADP-ribosylation factor 6 ( Arf6 ).
Once this post-translational modification process has been completed, the protein begins to fold ( sometimes spontaneously and sometimes with enzymatic assistance ), curling up on itself so that hydrophobic elements of the protein are buried deep inside the structure and hydrophilic elements end up on the outside.
Once inside the embassy, diplomatic channels can be used to solve the issue and send the refugees to another country.
Once inside the lumen, the molecules are modified, then sorted for transport to their next destinations.
Once inside, the DNA becomes expressed by the cell machinery, resulting in the production of therapeutic protein, which in turn treats the patient's disease.
Once the case is sized down, the inside of the neck of the case will actually be slightly smaller than the bullet diameter.
Once the punch has been evaded, the boxer " weaves " back to an upright position, emerging on either the outside or inside of the opponent's still-extended arm.
Once inside the lumen of the lymphatic vessels, the fluid is guided along increasingly larger vessels, first with rudimentary valves to prevent backflow, which later develop into complete valves similar to the venous valve.
Once inside, they used stolen keys to enter two apartments being used by the Israeli team at 31 Connollystraße.
Once inside, Blazkowicz destroys the V-2 on its launchpad and fights his way out of the facility towards an airbase filled with experimental jet aircraft.
Once inside, they called for backup from the Sixth Precinct using the bar's pay telephone.
Once clear, the two sides of the skin are distinct: the side facing inside the animal and the hair side.
Once inside the skin, dengue virus binds to Langerhans cells ( a population of dendritic cells in the skin that identifies pathogens ).
Once inside the periplasm, the Bdellovibrio cell seals the membrane hole and converts the host cell to a spheroblast.
Once inside the host, the larvae live inside the haemocoel and absorb nutrients directly through their skin.
Once and cell
Once the virus has infected the cell, it will start replicating itself, using the mechanisms of the infected host cell.
Once considered a technical snag in cell fractionation techniques, the alleged ER vesicle contaminants that invariably appeared in the mitochondrial fraction have been re-identified as membranous structures derived from the MAM — the interface between mitochondria and the ER.
Once activated, p53 will induce a cell cycle arrest to allow either repair and survival of the cell or apoptosis to discard the damaged cell.
Once the cell receives a physiological, pathological, or pharmacological stimulus, a number of cellular proteins are modified biochemically by signal cascades.
Once in the host's cell, the RNA strands undergo reverse transcription in the cytoplasm and are integrated into the host's genome, at which point the retroviral DNA is referred to as a provirus.
Once this fourth division has occurred the embryo has reached a 16 cell stage.
Once colonization has begun, the biofilm grows through a combination of cell division and recruitment.
Once an embolism is formed, it usually cannot be removed ( but see later ); the affected cell cannot pull water up, and is rendered useless.
Once the elders returned to the cell, the seal was still in place, but Joseph was gone.
Once in the synapse, dopamine binds to and activates postsynaptic dopamine receptors, resulting in the signal of the presynaptic cell being propagated to the postsynaptic neuron.
Once a virus genome becomes operational in a host cell, it then generates messenger RNA ( mRNA ) molecules that direct the synthesis of viral proteins.
Once a tyrosine receptor kinase is bonded to its ligand, it is able to bind to tyrosine kinase residing in the cytosol of the cell.
Once the PMCs disrupt all attachment to their former location, the cells themselves change their morphology by contracting their apical surfaces, apical constriction, and enlarging their basal surfaces, thus acquiring a “ bottle cell ” phenotype.
Once the unit cell of a new phase is known, the next step is to establish the stoichiometry of the phase.
Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters.
Once this has happened, the row is " open " ( the desired cell data is available ).
The chromosomes ’ connection allows the cells to join together — making sure that the two copies are “ lined up together at the center of the dividing cell .” Once the chromosomes are aligned, tiny molecular spindles attach to each copy and then pull away the “ original and new copy ” as the division continues.
Once and they
Once we send out the whole pie, they can put their pieces into it.
Once out of the gate they had charged straight up the narrow lane.
Once, they were at Easthampton for the summer ( again, Fritzie said, a good place, even though they were being robbed ).
Once there had been big glittering rooms where Ulanys bowed and kissed the ladies' hands as they flirted from behind their fans.
Once her trembling hand, with the pen grasped tight in it, was pressed against the paper the words came sharply, smoothly, as authoritatively as they would dropping from her own lips.
Once in a while they said what a shame it was, with Granny dying, but they all agreed she wouldn't have wanted it any other way.
Once settled, we're careful to walk the dogs in an out of the way spot, keep them under control in the room, and feed and bench them where they can't do any harm to the furnishings or the furniture.
Once many significant phrases are found in theory or in recurrent practice to provide for prosodic necessity, they are not to be defended for their semantic properties in isolated contexts.
Once the Orthodox Trinitarians succeeded in defeating Arianism, they censored any signs that the perceived heresy left behind.
Once they were gone, Abd a-Rahman and Bedr immediately set off westwards.
Once a forecasting error is made by agents, due to a stochastic shock, they will be unable to correctly forecast the price level again even if the price level experiences no further shocks since they only ever incorporate part of their errors.
Once " stand off " nuclear weapon designs were developed, bombers did not need to pass over the target at high altitude to make an attack ; they could fire and turn away to escape the blast.
Once players have mastered these basic strokes, they can hit the shuttlecock from and to any part of the court, powerfully and softly as required.
Once again they fell back across the stream.
Once, when his younger son Leonid fell seriously ill, Zinaida extracted a promise from her husband, as they stood by the boy's sickbed, that he would end his affair with Olga Ivinskaya.
Once the keys had been pressed they were locked down until mechanical contacts in a distributor unit passed over the sector connected to that particular keyboard, when the keyboard was unlocked ready for the next character to be entered, with an audible click ( known as the " cadence signal ") to warn the operator.
Once the account exceeded its quotas, it was automatically disabled, but the messages were still saved as they arrived.
Once the price of inkjet printers dropped to the point where they were competitive with dot matrix printers, dot matrix printers began to fall out of favor for general use.
Once they got back to Siena they reopened the bag and her head was visible once more.
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