Upon exiting the endoplasmic reticulum and entering the Golgi apparatus via vesicular transport, a specific lysosomal tag, mannose 6-phosphate, is added to the peptides.

Upon entering all service all three V bombers were initially painted in an overall silver finish, with the prominent under-nose H2S radomes on the Valiant and Vulcan left in black, however, this silver finish was later changed to one of anti-flash white, the RAF roundels being adjusted in shade, and made paler, to minimise the absorption of energy from the flash of detonating nuclear weapons.

Upon entering this coalition, Pitt said to Devonshire: " My Lord, I am sure I can save this country, and no one else can ".

Upon entering the CTV, astronauts could take off their launch and re-entry suits then proceed to chairs and beds for medical checks before being transported back to the crew quarters in the Operations and Checkout Building.

Upon entering higher education James worked as a school janitor, bellringer, carpenter, teacher, and preacher to help finance his education.

Upon both of them entering and tying for first place in a scientific contest at the University of Paris, Johann, unable to bear the " shame " of being compared as Daniel's equal, banned Daniel from his house.

Upon entering the Ying Wa College, new students are divided into five houses.

Upon entering the government, Allende relinquished his parliamentary seat for Valparaíso, which he had won in 1937.

Upon entering office in June 1970, Heath immediately set about trying to reverse Wilson's policy of ending Britain's military presence East of Suez.

Upon their arrival at Columbine, the duo met near Harris's car and armed two 20 pound ( 9 kg ) propane bombs before entering the cafeteria a few minutes prior to the beginning of the A lunch shift, placing the duffel bags containing the bombs inside.

Upon entering Oradour-sur-Glane, Sturmbannführer Diekmann had received orders from his regimental commander, Standartenführer Stadler, to only have the mayor of the town name thirty people who could serve as hostages in exchange for Sturmbannführer Kämpfe ; however, Diekmann instead ordered the population exterminated and the village burned to the ground.

Upon entering the US Open as the defending champion that year, he caused controversy when, after losing in the quarterfinals to Jim Courier, Sampras said that he was not disappointed and felt relieved that the pressure to defend his title was no longer on him.

) Upon entering office, President Woodrow Wilson segregated the United States Navy.

Upon entering his third season as Pistons coach, Saunders became the longest-tenured Pistons coach since Chuck Daly's nine-year tenure ( 1983 – 92 ).

Upon entering Nootka Sound, they found William Douglas and his ship the Iphigenia.

Upon entering the service of the Church he was placed at the head of the Catechetical School of Alexandria, where he lived and worked.

Upon entering either mode, the player will be able to select a course, find out which fruit will be the Lucky Fruit, and choose a Yoshi of desired colour to play as.

Upon entering Red Bank, County Route 520, along with County Route 11, head north on Broad Street and Route 35 heads northwest on two-lane Maple Avenue, which turns north and passes by numerous homes.

Upon entering Rahway, Route 35 crosses under the Northeast Corridor rail line just before ending at Route 27.

Upon entering the town of Blairsville, Georgia, one can see a plaque crediting John Thomas ( former Justice of the Inferior Court and serving Union County in the Georgia House of Representatives in 1833 ) for giving the county the name of Union.

Upon entering Paramus, Route 4 has a cloverleaf interchange with County Route 62 ( Paramus Road / Passaic Street ).

Upon entering Folsom, the route passes over a Conrail Shared Assets Operations railroad line before coming to a cloverleaf interchange with US 322 ( Black Horse Pike ).

( Upon entering 6th grade, all students attend Peacock Jr. High ( Currently Peacock Middle School ) on the town's North Side.

Upon entering Salem at approximately 9 a. m., Morgan immediately took possession of the town and placed guards over the stores and streets.

Upon declaring the game over, the player is allowed to complete his turn ( including buying stock ).

Upon defeating Surtur, the player seats upon the throne, completing the game.

Upon making this breakthrough, Carmack and Hall stayed up late into the night making a replica of the first level of the popular 1988 NES game Super Mario Bros. 3, inserting stock graphics of Romero's Dangerous Dave character in lieu of Mario.

Upon returning from vacation, he was surprised to find that his store did not carry the game.

* Once Upon a Time, a card game about creating Fairy Tales

Upon bringing back hunted game meat, the Aborigines would preserve the meat with either millet wine or salt.

Upon losing the last, he or she is taken out of the game and in three-four players game, turned into walking bombs that explode when they come in contact with other players.

* Upon playing his last playoff game in 1980, he and teammate Gordie Howe became the last active players that had played in the 1950s.

Upon its release, Marble Madness was commercially successful, becoming a profitable arcade game.

Upon application, the development team was surprised at how well it meshed with their fighting system, and decided to build the rest of the game around it.

Upon successfully completing the game, the player successfully unites China under the Shu Han banner.

Upon entering level 3, Arnold and Juni are forced to battle each other, the loser getting an immediate game over.

Upon fully completing the game on the hardest difficulty setting, an additional " 007 " mode is unlocked that allows the player to customize the challenge of any mission by manually adjusting enemies ' health, reaction times, aiming accuracy, and the damage they inflict.

Upon graduation, Shimomura intended to become a piano instructor and was extended a job offer to become a piano teacher at a music store, but as she had been an avid gamer for many years she decided to send some samples of her work to various video game companies that were recruiting at the university.

Upon its release, Vice City became the best-selling video game of 2002.

Upon its release on the SNES, VideoGames reviewer Tyrone Rodriguez gave the game a score of 8 ( Great ), stating his preference of it over Mortal Kombat 3 ( the other editors ' additional scores being 8-6-6 ).

Upon its destruction, the narrator of the game is revealed to be the Baron himself, trapped within the machine and studded with implants.

Upon starting the game, the player is equipped with a gun and bullets, which were taken from a dead guard.

Upon completing either game, players receive a password that can be used to play an alternative version of the other.

Upon completing the alternative game, another password is shown that gives the player the Victory Ring, which commemorates the defeat of Ganon.

Upon arrival at their next challenge, the tribes found they faced another twist, as the six voted-off players were returned to the game as an " Outcast tribe ".

Upon their publication in 1979, White Dwarf magazine reviewer Don Turnbull gave the Trilogy a 4 out of 10 rating, stating that he was perplexed as to whether the books were supposed to be a supplement to Dungeons & Dragons or a standalone game.

Upon his arrival, Alex discovers that the images and territories in the Starfighter arcade game represent an actual conflict between the Rylan Star League and the Ko-Dan Empire ; the latter is led by Xur ( Norman Snow ), a traitor to whom the Ko-Dan Emperor has promised control of Rylos itself.