While many of these cases involve cloned embryos or subsequent rejection of the paternal mitochondria, others document in vivo inheritance and persistence under lab conditions.

While these DNAzymes have been demonstrated to be useful for constructing logic gates, they are limited by the need for a metal cofactor to function, such as Zn < sup > 2 +</ sup > or Mn < sup > 2 +</ sup >, and thus are not useful in vivo.

While ex vivo, many cells continue to live and metabolize until they are " fixed ".

While miltefosine had therapeutic effects during an in vivo study in mice, chlorpromazine ( Thorazine ) showed to be the most effective substance-the authors concluded: " Chlorpromazine had the best therapeutic activity against N. fowleri in vitro and in vivo.

While over 28 single nucleotide polymorphisms ( SNPs ) have been identified in the CYP3A4 gene, it has been found that this does not translate into significant interindividual variability in vivo.

While toxication is generally undesirable, in certain cases it is required for the in vivo conversion of a prodrug or chemical to a metabolite with desired pharmacological or toxicological activity.

While working on this subject, he discovered a family of peptides present in the venom of a Brazilian snake, Bothrops jararaca, which inhibited kininase activity and strongly potentiated the effects of bradykinin in vivo and in vitro.

While there is no published in vivo data on compounds of this type, the structural data acquired from in vitro studies have expanded the current understanding of how a number of important kinases recognize target substrates.

While this approach has been successful in some cases, mutations are permanent in vivo and can have potentially detrimental effects on protein folding and stability.

While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage.

While spumaviruses will form characteristic large vacuoles in their host cells while in vitro, there is no disease association in vivo.

While the pattern is uneven, some having gained more than others, nationalism has in fact served the Western peoples well.

While sovereignty has roots in antiquity, in its present usage it is essentially modern.

While it is hazardous to project the trend of history, it seems clear that a genuine community is painfully emerging in the Western world, particularly among the countries of Western Europe.

While he is worldly, the musician often cultivates public attitudes of childlike astonishment and naivete.

While some think we move too fast and others too slowly, Florida's record is a good one and stands out among the 50.

While white is the coolest summer shade, there are lots of pastel hues along with tintable fabrics that will blend with any wardrobe color.

While it is easy enough to ridicule Hawkins' pronouncement in Pleas Of The Crown from a metaphysical point of view, the concept of the `` oneness '' of a married couple may reflect an abiding belief that the communion between husband and wife is such that their actions are not always to be regarded by the criminal law as if there were no marriage.

While this may well be true in general, I believe it is also important to keep in mind that some recent developments suggest that over the next year or so military electronics may be one of the most strongly growing areas in an economy which is not expanding rapidly in other directions.

While clay is still pressed in mold, press three equally spaced holes 1/4'' '' deep, using pencil eraser, in bottom of clay to allow for proper drying and firing.

While assembled lid is still on design head, gently but firmly press it on plaster board.

While some regression is inevitable, it is discouraged rather than encouraged so that the transference does not follow the stages of planned regression associated with certain casework adaptations of the psychoanalytic model for insight therapy.

While other conditions might be even more effective in bringing about a change from immobility to mobility in Kohnstamm reactivity, it is our hypothesis that all such conditions would have as a common factor the capacity to induce an attitude in the subject which enabled him to divorce himself temporarily from feelings of responsibility for his behavior.

While we had expected that compulsive children in the unstructured school setting would have difficulty when compared to those in the structured, we were surprised to find that the achievement of the high compulsives within the schools where the whole-word method is used in beginning reading compares favorably with that of the low compulsives.

While roleplaying for testing is not too well understood at the present time, it represents one of the major uses of this procedure.

While the phonemes can be very easily stated, no one is likely to be satisfied with the statement until phonemic occurrences can be related in some way to morphemic units, i.e. until the morphophonemics is worked out, or at least far enough that it seems reasonable to expect success.

While the U. S. Department of Labor has a program of projecting industry and occupational employment trends and publishing current outlook statements, there is little tangible evidence that these projections have been used extensively in local curriculum planning.

While it had long been known in general, that `` the public is always wrong '', the use of odd-lot indices now puts the adage on a statistical basis.

While there may be several such industries to which the model of this paper is applicable, the authors make particular claim of relevance to the explanation of the course of wages and prices in the steel industry of the United States since World War 2.

While this influence is a complex matter, depending upon personality factors in the individual as well as upon his social-class experience, there probably are some general statements about social-class background and educational policy that can be made with a fair degree of truth.

While one element is announcing progress, another is delineating its problems.

While this was being discussed, we saw the militia to the west of us fanning out and breaking into little clusters of two and three men as they approached the road.

While women had always attended ball games in small numbers ( it was the part of a `` dead game sport '' in the early years of the twentieth century to be taken out to the ball park and to root, root, root for the home team ), they had often sat in patient martyrdom, unable even to read the scoreboard, which sometimes seemed to indicate that one team led another by a score of three hundred and eighty to one hundred and fifty-one.

While the Mercury capsule could only support one astronaut on a limited Earth orbital mission, the Apollo spacecraft was to be able to carry three astronauts on a circumlunar flight and eventually to a lunar landing.

While in the US, Bohr married Marietta Soffer ; the couple had three children, Vilhelm, Tomas and Margrethe.

While ascribing the divine attributes and divinity to each person of the Trinity, thus avoiding subordinationism, the first half of the Athanasian Creed also stresses the unity of the three persons in the one Godhead, thus avoiding a theology of tritheism.

While traditional teaching maintains that any bishop with apostolic succession can validly perform the ordination of another bishop, some churches require two or three bishops participate, either to ensure sacramental validity or to conform with church law.

While a board may have several committees, two -- the compensation committee and audit committee -- are critical and must be made up of at least three independent directors and no inside directors.

While Smith was always an artist who worked in several very different media, it is possible to identify three distinct periods in which one form of art had precedence over the others.

While most of these testimonies represent ailments neither diagnosed nor treated by medical professionals, the Church does require three other people to vouch for any testimony published in its official organ, the Christian Science Journal.

While en route to Chongqing, the Nationalist army intentionally started the " fire of Changsha ", which lasted for three days, destroyed two thirds of the city, killed twenty thousand civilians, and left hundreds of thousands of people homeless.

While this aspect is similar to Scotch and Irish whisky regulations, it contrasts with the maximum alcoholic proof limits on distillation ( 80 % abv ) and aging ( 62. 5 % abv ) purity allowed in the production of straight whiskey in the U. S. All spirits used in making a Canadian whisky must be aged for at least three years in wooden barrels of not greater than 700 L capacity ( a requirement similar to that for Scotch and Irish whisky and longer than for American straight whisky ).

While the SuperNOVA used three 15 × 15 " boards to implement the CPU and its memory, the Nova 2 fitted all of this onto a single board.

While Jackson considers the theatrical releases of those three films to be a final " director's cut " within the constraints of theatrical exhibition, the extended cuts were produced so that fans of the material could see nearly all of the scenes shot for the script to develop more of J. R. R. Tolkien's world, but which were originally cut for running time, or other reasons.

* 1962 – Mercury program: While aboard Friendship 7, John Glenn becomes the first American to orbit the earth, making three orbits in 4 hours, 55 minutes.

While the three formulae above are a direct expression in logic of what is known, they do not suffice to correctly draw consequences.

While the following conditions ( representing the expected situation ) are consistent with the three formulae above, they are not the only ones.

While the first three truths are primarily concerned with understanding the nature of dukkha ( suffering, anxiety, stress ) and its causes, the fourth truth presents a practical method for overcoming dukkha.

While similar in appearance to the original cars, it was bigger, wider, and three inches taller than the original 40 inches ( 1. 02 m ).

While Sanskrit has six classes, Latin is traditionally said to have five declension classes, and Ancient Greek three declension classes.

While the self-designation of hobbyists as hackers is acknowledged by all three kinds of hackers, and the computer security hackers accept all uses of the word, people from the programmer subculture consider the computer intrusion related usage incorrect, and emphasize the difference between the two by calling security breakers “ crackers ” ( analogous to a safecracker ).

While the Sidhe retreats, one elf ( revealed in the sequel to be named Corvus ), sets off on a quest of vengeance against the weakest of the three Serpent Riders, D ' Sparil.

While it is true that three power strokes typically occur per rotor revolution due to the 3: 1 revolution ratio of the rotor to the eccentric shaft, only one power stroke per shaft revolution actually occurs ; this engine provides three power ' strokes ' per revolution per rotor giving it a greater power-to-weight ratio than piston engines.

While in Baltimore the team advanced to the postseason ten times and won three NFL Championship games in 1958, 1959 and 1968.