* 1621 – Cristofano Allori, Italian painter ( b. 1577 )

* 1621 – Gerbrand van den Eeckhout, Dutch painter ( d. 1674 )

He was the father of the painter Cristofano Allori ( 1577 – 1621 ).

* 1578 – Philip III of Spain ( d. 1621 )

* 1682 – Avvakum, Russian priest and writer ( b. 1621 )

* 1621 – The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England.

Ambrosius Bosschaert the Elder ( 18 January 1573 – 1621 ) was a still life painter of the Dutch Golden Age.

* 1621 – Roger Boyle, 1st Earl of Orrery, English soldier, statesman, and dramatist ( d. 1679 )

(; 4 October 1542 – 17 September 1621 ) was an Italian Jesuit and a Cardinal of the Catholic Church.

Under Pope Paul V ( reigned 1605 – 1621 ), a major conflict arose between Venice and the Papacy.

* 1621 – Charles d ' Albert, Constable of France ( b. 1578 )

* 1621 – Saint Job of Maniava, Ukrainian Orthodox Saint ( b. 1550 )

* 1621 – Katarina Stenbock, Queen of Gustav I of Sweden ( b. 1535 )

* 1621 – Rebecca Nurse, English colonist executed during Salem witch trials ( d. 1692 )

* 1571 – Michael Praetorius, German composer ( d. 1621 )

* 1621 – Myles Standish is appointed as first commander of Plymouth colony.

* 1621 – Johannes Schefferus, Alsatian humanist ( d. 1679 )

* 1621 – Gregory XV becomes Pope, the last Pope elected by acclamation.

During the 17th century, the French fabulist Jean de La Fontaine ( 1621 – 1695 ) saw the soul of the fable in the moral — a rule of behavior.

* Jean de La Fontaine ( French, 1621 – 95 ).

* 1621-Second battle of Gibraltar on which a Spanish squadron crushed the VOC at the strait of Gibraltar – Battle of Gibraltar ( 1621 )

Galileo initially called his discovery the Cosmica Sidera (" Cosimo's stars "), in honour of Cosimo II de ' Medici ( 1590 – 1621 ).

In his reign ( 1598 – 1621 ) a ten year truce with the Dutch was overshadowed in 1618 by Spain's involvement in the European-wide Thirty Years ' War.

Philip III was succeeded in 1621 by his son Philip IV of Spain ( reigned 1621 – 1665 ).

* August 17 – Guillaume Herincx, Flemish theologian and Bishop of Ypres ( b. 1621 )

* March 7 – Guillaume du Vair, French statesman and philosopher ( d. 1621 )

Guillaume du Vair ( Paris, 7 March 1556 – Tonneins, 3 August 1621 ) was a French author and lawyer.

In 1621, his daughter Guillemette married Guillaume Couillard who joined the family business.

Just below the gardens is the Porte du Château of 1621, the last substantial part of the old castle to remain standing.

In 1621 he moved to Paris, where he worked with Nicolas Poussin on the decoration of the Palais du Luxembourg under the direction of Nicolas Duchesne, whose daughter he married.

* 1621 – Anne de Xainctonge, French saint, founder of the Society of the Sisters of Saint Ursula of the Blessed Virgin ( b. 1567 )

* 1621 – Jean de La Fontaine, French writer ( d. 1695 )

* 1707 – Philibert, comte de Gramont, French writer ( b. 1621 )

* 1621 – Louis, Grand Condé, French general ( d. 1686 )

* January 10 – Philibert, comte de Gramont, French writer ( b. 1621 )

* April 13 – Jean de la Fontaine, French writer noted for his fables ( b. 1621 )

** François Pithou, French lawyer and author ( d. 1621 )

* November 21 – Anne de Xainctonge, French saint ( d. 1621 )

** Louis II de Bourbon, Prince de Condé, French general ( b. 1621 )

The earliest known advocates of British Israelism include M. le Loyer, an early 16th-century French Huguenot magistrate ; Adriaan van der Schrieck, a Flemish scholar ( d. 1621 ); Vincenzo Galilei ; the English antiquarian Henry Spelman ; Jakob Abbadie ; and John Sadler.

French poet Théophile de Viau wrote Les amours tragiques de Pyrame et Thisbée, a tragedy in five acts ( 1621 ).

In 1621, sixty years after Garamond ’ s death, the French printer Jean Jannon issued a specimen of typefaces that had some characteristics similar to the Garamond designs, though his letters were more asymmetrical and irregular in slope and axis.

Louis de Bourbon, Prince of Condé ( 8 September 1621 – 11 December 1686 ) was a French general and the most famous representative of the Condé branch of the House of Bourbon.

* April 13-Jean de la Fontaine, French poet ( born 1621 )

He lost the governorship of Saumur at the time of the Huguenot insurrection in 1621 as Saumur was captured by French royal forces, and died in retirement on his estate of La Forêt-sur-Sèvre, Deux-Sèvres.

Françoise Bertaut de Motteville ( c. 1621 – 1689 ), French memoir writer, was the daughter of Pierre Bertaut, a gentleman of the king's chamber, and niece of the bishop-poet Jean Bertaut.

François Pithou ( 1543 – 1621 ) was a French lawyer and author.

Charles Bonaventure de Longueval, Count of Bucquoy ( Czech Karel Bonaventura Buquoy, full name in French Charles Bonaventure de Longueval comte de Bucquoy, German: Karl Bonaventura Graf von Buquoy ) ( Arras, 9 January 1571 – Nové Zámky, 10 July 1621 ) was a military commander who fought for the Holy Roman Empire during the Thirty Years ' War.

Philibert, comte de Gramont ( 1621 – 310 January 1707 ) was a French nobleman, known as the protagonist of the Mémoires written by Antoine Hamilton.

His teachers possibly included Johann Ulrich Steigleder, and he might have met Samuel Scheidt during the latter's visit to Stuttgart in 1627 ; it is possible that Froberger sang in the court chapel, but there is no direct evidence to that ; and court archives indicate that one of the English lutenists employed by the court, Andrew Borell, taught lute to one of Basilius Froberger's sons in 1621 – 22 – it is not known whether this son was Johann Jakob, but if so, it would explain his later interest in French lute music.