* 1621 – Cristofano Allori, Italian painter ( b. 1577 )

* 1621 – Guillaume du Vair, French writer ( b. 1556 )

* 1621 – Gerbrand van den Eeckhout, Dutch painter ( d. 1674 )

He was the father of the painter Cristofano Allori ( 1577 – 1621 ).

* 1578 – Philip III of Spain ( d. 1621 )

* 1682 – Avvakum, Russian priest and writer ( b. 1621 )

* 1621 – The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England.

Ambrosius Bosschaert the Elder ( 18 January 1573 – 1621 ) was a still life painter of the Dutch Golden Age.

(; 4 October 1542 – 17 September 1621 ) was an Italian Jesuit and a Cardinal of the Catholic Church.

Under Pope Paul V ( reigned 1605 – 1621 ), a major conflict arose between Venice and the Papacy.

* 1621 – Charles d ' Albert, Constable of France ( b. 1578 )

* 1621 – Saint Job of Maniava, Ukrainian Orthodox Saint ( b. 1550 )

* 1621 – Katarina Stenbock, Queen of Gustav I of Sweden ( b. 1535 )

* 1621 – Rebecca Nurse, English colonist executed during Salem witch trials ( d. 1692 )

* 1571 – Michael Praetorius, German composer ( d. 1621 )

* 1621 – Myles Standish is appointed as first commander of Plymouth colony.

* 1621 – Johannes Schefferus, Alsatian humanist ( d. 1679 )

* 1621 – Gregory XV becomes Pope, the last Pope elected by acclamation.

During the 17th century, the French fabulist Jean de La Fontaine ( 1621 – 1695 ) saw the soul of the fable in the moral — a rule of behavior.

* Jean de La Fontaine ( French, 1621 – 95 ).

* 1621-Second battle of Gibraltar on which a Spanish squadron crushed the VOC at the strait of Gibraltar – Battle of Gibraltar ( 1621 )

Galileo initially called his discovery the Cosmica Sidera (" Cosimo's stars "), in honour of Cosimo II de ' Medici ( 1590 – 1621 ).

In his reign ( 1598 – 1621 ) a ten year truce with the Dutch was overshadowed in 1618 by Spain's involvement in the European-wide Thirty Years ' War.

Philip III was succeeded in 1621 by his son Philip IV of Spain ( reigned 1621 – 1665 ).

** Roger Crab, English Puritan political writer ( b. 1621 )

* October 26 – Roger Boyle, 1st Earl of Orrery, British soldier, statesman, and dramatist ( b. 1621 )

* Roger Boyle, 1st Earl of Orrery ( 1621 – 1679 )

* Roger Boyle, 1st Earl of Orrery ( 1621 – 1679 ), Irish soldier, statesman and dramatist

* Roger Boyle, 1st Earl of Orrery ( 1621 – 1679 )

Roger Boyle, 1st Earl of Orrery ( 25 April 1621 – 16 October 1679 ) was a soldier, dramatist and politician from the British Isles who sat in the House of Commons of England at various times between 1654 and 1679.

Roger Crab ( 1621 – September 11, 1680 ) was an English soldier, haberdasher, herbal doctor and writer who is best known for his ascetic lifestyle which included Christian vegetarianism.

* October 26-Roger Boyle, 1st Earl of Orrery ( born 1621 )

* 1621 – Anthony Ashley Cooper, 1st Earl of Shaftesbury, English politician ( d. 1683 )

* Thomas Coventry, 1st Baron Coventry of England ( 1578 – 1640 ), Judge, Member of Parliament, and politician ( Specifically Soliticar General ( 1617 – 1621 ), Attorney General ( 1621 – 1625 ), and Lord Chancellor ( 1625 – 1640 ))

* January 21 – Anthony Ashley-Cooper, 1st Earl of Shaftesbury, British politician ( b. 1621 )

* Ferryland, Newfoundland granted to George Calvert, 1st Baron Baltimore in 1620, first settlers in August 1621

* Edward Seymour, 1st Earl of Hertford ( second creation of that title ) ( 22 May 1539 – 1621 ), married firstly in November 1560, Lady Catherine Grey, by whom he had two sons ; he married secondly in 1582, Frances Howard ; and thirdly in 1601, Frances Prannell.

* Henry Montagu, 1st Earl of Manchester ( September 1621 – July 1628 )

* Claud Hamilton, 1st Lord Paisley ( 1543 – 1621 ) was a Scottish politician

1670 ), eldest son of the 1st Earl, succeeded his grandfather as 2nd Lord Paisley in 1621

* Heneage Finch, 1st Earl of Nottingham ( 1621 – 1682 )

Anthony Ashley Cooper, 1st Earl of Shaftesbury PC ( 22 July 1621 – 21 January 1683 ), known as Anthony Ashley Cooper from 1621 to 1631, as Sir Anthony Ashley Cooper, 2nd Baronet from 1631 to 1661, and as The Lord Ashley from 1661 to 1672, was a prominent English politician during the Interregnum and during the reign of King Charles II.

* Anthony Ashley-Cooper, 1st Earl of Shaftesbury ( 1621 – 1683 )

* Edward Seymour, 1st Earl of Hertford ( 1539 – 1621 )

* Robert Melville, 1st Lord Melville ( 1547 – 1621 )

* Francis Bacon, 1st Baron Verulam ( 1561 – 1626 ) ( became Viscount St Albans in 1621 )

* Sir Thomas Gerard, 1st Baronet ( 1560 – 1621 )

But he was liberated on 16 July 1621, after the new Lord Chancellor John Williams had prevailed with George Villiers, 1st Duke of Buckingham to recommend to James I an exercise of his prerogative of mercy in the case of political prisoners.