* 1621 – Cristofano Allori, Italian painter ( b. 1577 )

* 1621 – Guillaume du Vair, French writer ( b. 1556 )

* 1621 – Gerbrand van den Eeckhout, Dutch painter ( d. 1674 )

He was the father of the painter Cristofano Allori ( 1577 – 1621 ).

* 1578 – Philip III of Spain ( d. 1621 )

* 1682 – Avvakum, Russian priest and writer ( b. 1621 )

* 1621 – The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England.

Ambrosius Bosschaert the Elder ( 18 January 1573 – 1621 ) was a still life painter of the Dutch Golden Age.

* 1621 – Roger Boyle, 1st Earl of Orrery, English soldier, statesman, and dramatist ( d. 1679 )

(; 4 October 1542 – 17 September 1621 ) was an Italian Jesuit and a Cardinal of the Catholic Church.

Under Pope Paul V ( reigned 1605 – 1621 ), a major conflict arose between Venice and the Papacy.

* 1621 – Charles d ' Albert, Constable of France ( b. 1578 )

* 1621 – Saint Job of Maniava, Ukrainian Orthodox Saint ( b. 1550 )

* 1621 – Katarina Stenbock, Queen of Gustav I of Sweden ( b. 1535 )

* 1571 – Michael Praetorius, German composer ( d. 1621 )

* 1621 – Myles Standish is appointed as first commander of Plymouth colony.

* 1621 – Johannes Schefferus, Alsatian humanist ( d. 1679 )

* 1621 – Gregory XV becomes Pope, the last Pope elected by acclamation.

During the 17th century, the French fabulist Jean de La Fontaine ( 1621 – 1695 ) saw the soul of the fable in the moral — a rule of behavior.

* Jean de La Fontaine ( French, 1621 – 95 ).

* 1621-Second battle of Gibraltar on which a Spanish squadron crushed the VOC at the strait of Gibraltar – Battle of Gibraltar ( 1621 )

Galileo initially called his discovery the Cosmica Sidera (" Cosimo's stars "), in honour of Cosimo II de ' Medici ( 1590 – 1621 ).

In his reign ( 1598 – 1621 ) a ten year truce with the Dutch was overshadowed in 1618 by Spain's involvement in the European-wide Thirty Years ' War.

Philip III was succeeded in 1621 by his son Philip IV of Spain ( reigned 1621 – 1665 ).

* July 19 – Rebecca Nurse, accused witch ( b. 1621 )

The earliest known usage in print of the English term deist is 1621,

* 1621 – Thomas Willis, English physician ( d. 1675 )

* 1621 – Anthony Ashley Cooper, 1st Earl of Shaftesbury, English politician ( d. 1683 )

* 1621 – Andrew Marvell, English poet ( d. 1678 )

* 1621 – Radulph Agas, English surveyor ( b. c. 1540 )

** Roger Crab, English Puritan political writer ( b. 1621 )

* August – Matthew Locke ( composer ), English composer ( b. 1621 )

* October 27 – Mary Sidney, English writer, patroness and translator ( d. 1621 )

* June 2 – John Wildman, English soldier and politician ( b. c. 1621 )

* August 16 – Andrew Marvell, English writer ( b. 1621 )

* October 12 – Edmund Berry Godfrey, English magistrate ( b. 1621 )

Richard Zouch also Richard Zouche ( c. 1590 – 1 March 1661 ) was an English judge and politician who sat in the House of Commons from 1621 to 1624.

The earliest known advocates of British Israelism include M. le Loyer, an early 16th-century French Huguenot magistrate ; Adriaan van der Schrieck, a Flemish scholar ( d. 1621 ); Vincenzo Galilei ; the English antiquarian Henry Spelman ; Jakob Abbadie ; and John Sadler.

It was Monhegan traders who taught English to Samoset, the sagamore who in 1621 startled the Pilgrims by boldly walking into their new village at Plymouth and saying: " Welcome, Englishmen.

The name allspice was coined as early as 1621 by the English, who thought it combined the flavour of cinnamon, nutmeg, and cloves.

Sir John Coke ( 5 March 1563 – 8 September 1644 ) was an English office holder and politician who sat in the House of Commons at various times between 1621 and 1629.

Sir John Wildman ( c. 1621 – 2 June 1693 ) was an English politician and soldier.

It is named after Thomas Willis ( 1621 – 1675 ), an English physician.

The History of Tom Thumb was published in 1621, and has the distinction of being the first fairy tale printed in English.

* Cogswell, Thomas, The Blessed Revolution: English Politics and the Coming of War 1621 – 24 ( Cambridge, 1989 )

Sir Maurice Abbot ( Morris ) ( 1565 – 1642 ) was an English merchant and politician who sat in the House of Commons between 1621 and 1626.

Anthony Ashley Cooper, 1st Earl of Shaftesbury PC ( 22 July 1621 – 21 January 1683 ), known as Anthony Ashley Cooper from 1621 to 1631, as Sir Anthony Ashley Cooper, 2nd Baronet from 1631 to 1661, and as The Lord Ashley from 1661 to 1672, was a prominent English politician during the Interregnum and during the reign of King Charles II.