Because staining for cadherins and catenins in ingressing cells decreases and develops as intracellular accumulations, apical junctions are thought to be cleared by endocytosis during ingression.

Because RETGC-1 produces cGMP which keeps cyclic gated nucleotide channels open allowing the influx of calcium, this mutation causes extremely high intracellular calcium levels.

Because of their high degree of morphological and functional differentiation in vitro, HepG2 cells are a suitable model to study the intracellular trafficking and dynamics of bile canalicular and sinusoidal membrane proteins and lipids in human hepatocytes in vitro.

Because the anaerobic muscle fibre uses its fuel faster than the blood and intracellular restorative cycles can resupply it, the maximum number of repetitions is limited.

Because of the build-up of glucose, the polyol pathway increases its flux, and intracellular sorbitol and fructose accumulate.

Because Brucella suis are facultative intracellular and are able to adapt to environmental conditions in the macrophage, treatment failure and relapse rates are high.

Because enzyme catalysis in general is achieved by lowering the energy barrier between substrate and product, mutation of Q61 to K necessarily reduces the rate of intrinsic Ras GTP hydrolysis to physiologically meaningless levels.

Because the change in charge distribution makes the GTP substrate more like the products of the reaction, GDP and monophoshate, this, along with opening the molecule for nucleophilic attack, lowers the transition state energy barrier of the reaction and allows GTP to be hydrolyzed more readily.

Because God is what He is, the laws of the universe, material and spiritual, are what they are.

Because of these involvements in the matter at stake, Boniface lacked the impartiality that is supposed to be an essential qualification for the position of arbiter, and in retrospect that would seem to be sufficient reason why the English embassies to the Curia proved so fruitless.

Because of the means of publication -- science-fiction magazines and cheap paperbacks -- and because dystopian science fiction is still appearing in quantity the full range and extent of this phenomenon can hardly be known, though one fact is evident: the science-fiction imagination has been immensely fertile in its extrapolations.

Because administration of the forest highway system is a responsibility of the Secretary of Commerce with maintenance provided by the States and counties, this Development Program for the National Forests does not include estimates of the funds needed to maintain the forest highway system nor to construct the additions to it that are needed.

Because the bobbin-to-cone winding process is a relatively high-cost operation for the mill, the almost complete automation provided by the Uniconer can mean important economies in textile production, at the same time upgrading quality.

Because of its importance, and because the lack of price competition is well recognized, the industry is under considerable public pressure not to raise its price any more than could be justified by cost increases.

Because community not severalty of property is the law of nature no man can assert an absolutely unalterable right to what is his.

Because of undesirable flavors, odors, colors, and generally low palatability associated with radiation treatment of this magnitude, the inactivation of enzymes is best accomplished prior to irradiation by the conventional heat-processing methods of blanching.

Because agricultural activities are seasonal and the areas of production and harvest of many foods are widely scattered geographically, and because of the high cost of transporting bulk food items any substantial distance to a central processing location, the use of large central processing stations, where low-cost radiation facilities approaching the megawatt range might be utilized, is inherently impracticable.

Because the rake angle Af at the tip of the knife is very much smaller ( or even negative ) when compared to the value of **yc for the major portion of the knife, a very rapid increase in cutting force with thickness will result.

Because the food is selected with thought for its nutritional value, care for its origin, and prepared in a manner that retains the most nutrients, the food does taste good.

-- Held out of Texas Tech's sweat-suits drill Monday at Lubbock was tackle Richard Stafford, who is undergoing treatment for a leg injury suffered in the Raiders' 38-7 loss to Texas A & M Because of its important game with Arkansas coming up Saturday, Baylor worked out in the rain Monday -- mud or no mud.

Because it is so large a state, with marked contrasts in population density, the organization of the New York co-operative offers a cross-section of how the plan works.

Because of this Dr. Bonnor holds that the universe is becoming more thinly populated by stars and whatever else is there.

Because all living beings possess a soul, great care and awareness is essential in one's actions.

Because anthropology developed from so many different enterprises ( see History of Anthropology ), including but not limited to fossil-hunting, exploring, documentary film-making, paleontology, primatology, antiquity dealings and curatorship, philology, etymology, genetics, regional analysis, ethnology, history, philosophy, and religious studies, it is difficult to characterize the entire field in a brief article, although attempts to write histories of the entire field have been made.

Because most embryonic development is outside the parental body, it is subject to many adaptations due to specific ecological circumstances.

Because experimentation is iterative, the

Because the range of possible values for K < sub > a </ sub > spans many orders of magnitude, a more manageable constant, pK < sub > a </ sub > is more frequently used, where pK < sub > a </ sub >

Because of the island's sub-tropical location, Taiwan has an abundant supply of various fruit, such as papayas, starfruit, melons, and citrus fruit.

Because it is thought to be the most abundant mineral in Earth ’ s mantle at shallower depths, the properties of olivine have a dominant influence upon the rheology of that part of Earth and hence upon the solid flow that drives plate tectonics.

Because Triceratops teeth, horn fragments, frill fragments, and other skull fragments are such abundant fossils in the Lancian faunal stage of the late Maastrichtian ( late Cretaceous, 68 to 65 mya ) Period of western North America, it is regarded as among the dominant herbivores of the time, if not the most dominant herbivore.

Because of its central location within the state and its abundant supply of water, Milledgeville grew rapidly into a bustling frontier settlement.

Because of the rich soil and abundant land, many Japanese immigrants are part of Bell Gardens ’ early history.

Because of parking challenges in the downtown area, many thriving independent businesses can be found in convenient areas throughout the city where access for their customers is more centralized and parking is more abundant.

Because maintenance of diesel and steam engines was then very labor-intensive, there were many workers whose needs were served by abundant service businesses, such as restaurants and bars.

Because it is such a conspicuous species, forest containing kauri is generally known as kauri forest, although kauri need not be the most abundant tree.

Because of the region's abundant forests, lumbering developed as an industry, with four sawmills operated by water power on the Kennebec.

Because 60 is more than 2 × 24, the number 24 is abundant.

" Because of the complexity of the 鰲 (" o ") character, and because crows were abundant in the area, the Japanese changed the name to 烏山, meaning " bird mountain.

Because of the rainfall along the coast, which was abundant compared to other cities in Tripolitania, and supplemental water from underground springs, Misrata's inhabitants were able to engage in unusually fertile agriculture in this largely arid region.

Because photographic film and digital sensors are sensitive to ultraviolet ( which is abundant in skylight ) but the human eye is not, such light would, if not filtered out, make photographs look different from the scene visible to people, for example making images of distant mountains appear unnaturally hazy.

Because of American oak ’ s modest tannin contribution, the perfect first fill is a wine with abundant tannins and good texture ; it allows the fruit to interact harmoniously with the wood, which contributes a wide array of complex aromas and soft, yet very palatable tannins.

Because of the formation of permafrost in these sediments and their depositional environments, prehistoric bone, shell, and plant material are well preserved and abundant.

Because wood was so abundant, early truss bridges would typically use carefully fitted timbers for members taking compression and iron rods for tension members, usually constructed as a covered bridge to protect the structure.

Because gasoline is so cheap and abundant, and also because ethanol is taxed at a high level, early US automobiles are adapted to gasoline from the beginning.

Because the collection of DNA from an environment is largely uncontrolled, the most abundant organisms in an environmental sample are most highly represented in the resulting sequence data.

Because the cold season comes earlier to the mountains, there is abundant snow in the winter, hence the tea plants germinate later.

Because choline is very abundant in the cell, PLD activity does not significantly affect choline levels ; and choline is unlikely to play any role in signaling.

Because of the favorable climatic conditions, the land enjoys luxuriant vegetation, thus, it has abundant resources of different species of timber.

Because TSP1 is extremely large (~ 120 kDa monomer ), not very abundant and exerts multiple actions, its clinical usefulness is questionable.

Because of the shallow depth of the river and the somewhat poor water quality, game fish are not abundant in the Sauk River, Redhorse and sucker are found in most parts of the river.

Because of the abundant variety of this part of the Velebit range and its authenticity, the area was upgraded from its classification as a nature reserve to a national park in 1999, and started work in September the same year.